Western Kentucky Hilltoppers vs Indiana Hoosiers Prediction, Picks and Game Preview - 09/19/2026

Game Time: 4:00 pm ET, Saturday, September 19, 2026

Venue:  Memorial Stadium, Bloomington, IN

Where to Watch:  Peacock

DraftKings:  Point Spread:  WKU +44.5, Indiana -44.5; Over/Under:  60.5 points

Bet365:  Point Spread:  WKU +44.5, Indiana -44.5; Over/Under:  60.5 points

BetMGM:  Point Spread:  WKU +44.5, Indiana -44.5; Over/Under:  60.5 points

Western Kentucky Hilltoppers:  0-2 (0-0) (9th place, C-USA)

Indiana Hoosiers:  2-0 (0-0) (2nd place, Big Ten)

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Western Kentucky Hilltoppers:  lost their last game on the road against the Georgia Bulldogs 70-20.

Indiana Hoosiers:  won their last game at home against the Howard Bison 55-0.

Western Kentucky is entering this game with a 0-2 record overall and they have a 0-0 record in their conference games too. They are 0-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Georgia 70-20. Rodney Tisdale Jr. was the starting QB and he completed 6/14 passes for 31 passing yards, 0 touchdowns, and 1 interception. Brock Glenn led the team in rushing yards with 70 and 2 TDs. Quincy Burroughs led the receivers with 29 receiving yards on 2 receptions. Jaylen Lewis led the defense in that game with 7 tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

Indiana is entering this game with a 2-0 record overall and they have a 0-0 record in their conference games too. They are 2-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Howard 55-0. Josh Hoover was the starting QB and he completed 6/11 passes for 145 passing yards, 4 touchdowns, and 0 interceptions. Lee Beebe Jr. led the team in rushing yards with 112. Charlie Becker led the receivers with 81 receiving yards on 3 receptions and 3 TDs. Rolijah Hardy and Isaiah Jones each led the defense in that game with 5 tackles while Keishaun Calhoun led the defense in sacks with 2. Rolijah Hardy came away with the only interception for them in that one.

The current betting odds have Indiana listed as a 44.5 point favorite in this game according to Draftkings Sportsbook. Indiana has looked great in their games this season with their 2-0 record overall so far. They have looked great on their home field too with their 2-0 home record this season. Meanwhile, Western Kentucky hasn't looked good in their games this season with their 0-2 record overall so far. They haven't been a good road team either with their 0-2 road record this year. Western Kentucky is not a bad team and they are usually a contender in the Conference USA, but they have a brutal schedule to start the season. They got destroyed by Nevada in their season opener 49-14 and now they are coming off a 70-20 loss to Georgia in their last one. Georgia is ranked like one of the best teams in the nation this season and so is Indiana who is also the defending National Champion. Indiana got off to a slow start in week 1, but they ended up beating up on North Texas and now they are coming off a 55-0 win over Howard last week. They did play a weaker opponent with Howard being from the FCS, but they still looked a lot better with the defense playing great and the offense able to iron out some kinks with their new QB. Western Kentucky has been known for having a really good offense and they still put up some points last week despite getting blown out by one of the best teams in the nation, but they are going to be facing another great defense here and will have trouble moving the ball all day. Their defense has also been known to be terrible and they have looked terrible again this season with the points they have given up in 2 games. Look for Indiana to continue rolling in this one as they look to get into a groove going into conference play. The best way to place a bet here is on Indiana to cover the spread in this game. 

Western Kentucky Indiana Prediction:  Our NCAAF Pick for Saturday, September 19, 2026 (4:00 pm ET start time) is Indiana 63 Western Kentucky 7.

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Western Kentucky Hilltoppers: 3-6 ATS against Big 10 conference opponents. 0-2 ATS as an underdog of 31 or more points. 10-5 OVER in road lined games. 

Indiana Hoosiers: 17-10 ATS as a favorite. 9-3 ATS off a home win by 17 points or more. 12-6 ATS after scoring 37 points or more last game. 31-13 OVER off a home win by 17 points or more.

Western Kentucky Hilltoppers:  K. Hutchinson (WR) Questionable - Undisclosed.

Indiana Hoosiers:  N. Radicic (K) Questionable - Back. N. Marsh (WR) Questionable - Undisclosed.

“Looking for positives coming out of this game, one thing our young men did was they kept competing. They kept straining. Obviously, it was not good a lot of times. A lot of things we have to get better at if we're going to be a good football team.” - Tyson Helton after his team’s loss against Georgia in their last game. 

“Better taste in our mouth after this one. Got the shutout on defense, played a lot of people, emptied the bench, shortened the fourth quarter. We started to dominate up front, It started on offense and defensively it got to the point where they really couldn’t block us. The only issue was we couldn’t tackle their quarterback occasionally.” - Curt Cignetti after his team’s win against Howard in their last game. 

WR Barry, Moussa

WR Stafford Jr., Jonathan

WR Flowers, Cameron

TE Ezirim, CC

QB Tisdale Jr., Rodney

RB Allen, Ajay

WR Marsh, Nick

WR Becker, Charlie

WR Morris, Tyler

TE Schott, Brock

QB Hoover, Josh

RB Richard, Turbo

Passing: Rodney Tisdale Jr. (234)

Rushing: Ajay Allen (121)

Receiving: Cameron Flowers (74)

Touchdowns: Ajay Allen (2)

Passing: Josh Hoover (376)

Rushing: Turbo Richard (166)

Receiving: Charlie Becker (145)

Touchdowns: Charlie Becker (5)

Coaches:

Western Kentucky Hilltoppers: Tyson Helton (8th season)

Indiana Hoosiers: Curt Cignetti (3rd season)