Virginia Cavaliers vs Duke Blue Devils Prediction, Picks and Game Preview - 11/15/2025

Game Time: 3:30 pm ET, Saturday, November 15, 2025

Venue:  Wallace Wade Stadium, Durham, NC

Where to Watch:  ESPN2

DraftKings:  Point Spread:  UVA +5.5, Duke -5.5; Over/Under:  58.5 points

Bet365:  Point Spread:  UVA +5.5, Duke -5.5; Over/Under:  57.5 points

BetMGM:  Point Spread:  UVA +5.5, Duke -5.5; Over/Under:  58.5 points

Virginia Cavaliers:  8-2 (5-1) (2nd place, ACC)

Duke Blue Devils:  5-4 (4-1) (5th place, ACC)

Do not miss out on our expert handicapper analysis! Vegas Writer is on a HOT STREAK in college football on a 7-1 CFB RUN for +$5,960 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Virginia Cavaliers:  lost their last game at home against the Wake Forest Demon Deacons 16-9.

Duke Blue Devils:  lost their last game on the road against the UConn Huskies 37-34.

Virginia is entering this game with an 8-2 record overall and they have a 5-1 record in their conference games too. They are 5-1 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Wake Forest 16-9. Chandler Morris was the starting QB and he completed 3/6 passes for 19 passing yards, 0 touchdowns, and 0 interceptions before leaving injured and getting replaced by Daniel Kaelin who completed 18/28 passes for 145 yards. J'Mari Taylor led the team in rushing yards with 98. Trell Harris led the receivers with 60 receiving yards on 6 receptions. Kam Robinson led the defense in that game with 3 solo tackles and 7 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

Duke is entering this game with a 5-4 record overall and they have a 4-1 record in their conference games too. They are 2-2 in their home games, 3-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against UConn 37-34. Darian Mensah was the starting QB and he completed 22/31 passes for 222 passing yards, 3 touchdowns, and 2 interceptions. Nate Sheppard led the team in rushing yards with 100 and 2 TDs. Sean Brown led the receivers with 61 receiving yards on 5 receptions. Caleb Weaver led the defense in that game with 5 solo tackles and 0 assisted tackles while Caleb Weaver and Josiah Green each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Duke listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. Duke has looked good in their games this season with their 5-4 record overall and their 4-1 conference record which has them right near the top of the ACC. They aren't a ranked team and have taken some bad losses in non-conference games this season, but they can still get to the ACC Championship if they run the table. Meanwhile, Virginia has looked great in their games this season with their 8-2 record overall and their 5-1 conference record which has them right near the top of the ACC. They are currently ranked inside the top 25 and have a real chance at making the CFP, but they have been starting to fall apart lately. They have been playing with fire over the last month as they were winning a lot of 1 score games against bad teams in the ACC, even needing OT in some of those, and that finally caught up with them in their last one. They are off a bad 16-9 loss at home to Wake Forest in their last one and they lost their starting QB to injury. Morris could be out for this game now and that would be a huge blow to Virginia since this offense couldn't do anything against Wake Forest without him, but even with Morris playing, the offense hasn't looked great in their games lately. This is a big opportunity for Duke to keep their ACC Championship hopes alive and they are going to bring their best effort at home after losing to UConn in their last one. Duke can take advantage of the way Virginia has been struggling lately. The best way to place a bet here is on Duke to cover the spread in this game. 

Virginia Duke Prediction:  Our NCAAF Pick for Saturday, November 15, 2025 (3:30 pm ET start time) is Duke 35 Virginia 20.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Virginia Cavaliers Duke Blue Devils prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

Virginia Cavaliers: 20-12 ATS in all lined games. 7-1 ATS as an underdog of 3.5 to 10 points. 12-2 ATS when playing against a team with a winning record. 6-3 OVER as a road underdog. 6-3 OVER off a loss against a conference rival. 

Duke Blue Devils: 1-4 ATS after allowing 37 points or more last game. 3-6 ATS versus good rushing teams - averaging 4.75 rushing yards/carry or more. 4-7 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 3-0 OVER after a loss by 6 or less points. 

Virginia Cavaliers:  N. Vaughn (RB) Out - Undisclosed. J. Thomas (WR) Out - Undisclosed. K. Wigenton II (OG) Questionable - Undisclosed. B. York (OG) Questionable - Undisclosed. T. Ladd (WR) Questionable - Undisclosed. A. Greene Jr. (WR) Questionable - Undisclosed. A. Jones (S) Questionable - Undisclosed. D. Walker (CB) Questionable - Undisclosed. T. Simmons (DL) Questionable - Undisclosed. X. Brown (RB) Out - Knee. M. Thomas (OG) Out - Foot. G. Brosterhous (QB) Out - Foot. D. Twitty (TE) Out - Leg. J. Morris (CB) Out - Knee. M. Mills (OG) Out - Knee.

Duke Blue Devils:  E. Schaper (LB) Out - Undisclosed. N. Morris Jr. (LB) Questionable - Undisclosed. K. Robinson (CB) Questionable - Undisclosed. N. Kutufaris (OG) Questionable - Undisclosed. E. Scott (OG) Questionable - Undisclosed. J. Brown (OG) Questionable - Undisclosed. M. Sahakian (OG) Questionable - Undisclosed. M. Factor (LB) Questionable - Undisclosed. T. Moore (S) Questionable - Knee. V. Floyd (CB) Questionable - Undisclosed.

“They did their part to kind of keep us within striking range. Unfortunately, we didn't play complementary football.” - Tony Elliott after his team’s loss against WF in their last game. 

“The quarterback (Fagnano) is the real deal. We were well aware of that. It was a loss that in all three phases that we made too many mistakes." - Manny Diaz after his team’s loss against UConn in their last game. 

WR Edrine, Jahmal

WR Harris, Trell

WR Ross, Cam

TE Ennis, Sage

QB Morris, Chandler

RB Taylor, J'Mari

WR Hagans, Sahmir

WR Barkate, Cooper

WR Brown, Que'Sean

TE Hasley, Jeremiah

QB Mensah, Darian

RB Sheppard, Nate

Passing: Chandler Morris (2,088)

Rushing: J'Mari Taylor (784)

Receiving: Trell Harris (605)

Touchdowns: J'Mari Taylor (11)

Passing: Darian Mensah (2,794)

Rushing: Nate Sheppard (657)

Receiving: Cooper Barkate (824)

Touchdowns: Nate Sheppard (8)

Coaches:

Virginia Cavaliers: Tony Elliott (4th season)

Duke Blue Devils: Manny Diaz (2nd season)