Vanderbilt Commodores vs South Carolina Gamecocks Prediction, Picks and Game Preview - 09/13/2025

Game Time: 7:45 pm ET, Saturday, September 13, 2025

Venue:  Williams-Brice Stadium, Columbia, SC

Where to Watch:  SEC Network

DraftKings:  Point Spread:  Vanderbilt +4.5, South Carolina -4.5; Over/Under:  48.5 points

Bet365:  Point Spread:  Vanderbilt +4, South Carolina -4; Over/Under:  49 points

BetMGM:  Point Spread:  Vanderbilt +4, South Carolina -4; Over/Under:  48.5 points

Vanderbilt Commodores:  2-0 (0-0) (5th place, SEC)

South Carolina Gamecocks:  2-0 (0-0) (9th place, SEC)

Do not miss out on our expert handicapper analysis! ASA, Inc. is on a HOT STREAK in college football on a 4-0 CFB RUN for +$4,000 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Vanderbilt Commodores:  won their last game on the road against the Virginia Tech Hokies 44-20.

South Carolina Gamecocks:  won their last game at home against the South Carolina State Bulldogs 38-10.

Vanderbilt is entering this game with a 2-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Virginia Tech 44-20. Diego Pavia was the starting QB and he completed 12/18 passes for 193 passing yards, 2 touchdowns, and 1 interception. Makhilyn Young led the team in rushing yards with 95 and 1 TD. Tre Richardson led the receivers with 54 receiving yards on 3 receptions and 1 TD. Nick Rinaldi led the defense in that game with 4 solo tackles and 2 assisted tackles while Nick Rinaldi, CJ Heard, and Khordae Sydnor each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

South Carolina is entering this game with a 2-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against South Carolina State 38-10. LaNorris Sellers was the starting QB and he completed 11/19 passes for 128 passing yards, 1 touchdown, and 0 interceptions. Jawarn Howell led the team in rushing yards with 30. Vandrevius Jacobs led the receivers with 57 receiving yards on 4 receptions and 1 TD. DQ Smith led the defense in that game with 4 solo tackles and 2 assisted tackles while Desmond Umeozulu, Bryan Thomas Jr., Dylan Stewart, and Jaquavious Dodd each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have South Carolina listed as a 4.5 point favorite in this game according to Draftkings Sportsbook. South Carolina has looked good in their games this season with their 2-0 record overall. They beat VA Tech on a neutral field in their season opener and now they are off a win at home against South Carolina State. The offense hasn't looked great in either game, but South Carolina still has one of the best QB's in the nation and he will be looking to take a step in this game. The defense has also looked great in their first 2 games so moving the ball against them is not going to be easy. Meanwhile, Vanderbilt has looked good in their games this season with their 2-0 record overall. They beat up on a team from the FCS in their season opener and now they are off a really nice road win over VA Tech. They beat VA Tech 44-20 and their offense has looked great in their 2 games, but they were also losing that game at halftime and the defense didn't look great. They looked a lot better in the 2nd half, but Vandy still doesn't have a great defense this season and they will struggle to stop Sellers in this game like they did last season. Vandy was never even in the game with South Carolina last season and that was at home, now they have to play them here in their first conference game of the season on the road. Vanderbilt might put up more of a fight in this one with that improved offense, but South Carolina still has the better defense and that gives them a big edge at home with the talent they have. The best way to place a bet here is on South Carolina to cover the spread in this game. 

Vanderbilt South Carolina Prediction:  Our NCAAF Pick for Saturday, September 13, 2025 (7:45 pm ET start time) is South Carolina 21 Vanderbilt 13.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Vanderbilt Commodores South Carolina Gamecocks prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

Vanderbilt Commodores: 19-26 ATS off an upset win as an underdog. 20-29 1H ATS after scoring 37 points or more last game. 32-20 UNDER as an underdog of 3.5 to 10 points. 28-10 UNDER in a road game where the total is between 42.5 and 49. 

South Carolina Gamecocks: 9-5 ATS as a favorite. 5-1 ATS when the total is between 42.5 and 49. 11-5 ATS against conference opponents. 5-0 UNDER off a home win by 17 points or more. 7-1 UNDER after scoring 37 points or more last game.

Vanderbilt Commodores:  J. St-Hilaire (QB) Questionable - Nose.

South Carolina Gamecocks:  B. Hunt (TE) Doubtful - Undisclosed. J. Geer (DL) Questionable - Undisclosed. J. Collier (CB) Questionable - Knee. K. Sakyi-Prah (DL) Out - Lower Body. G. Wilson Jr. (LB) Out - Undisclosed. J. Brown (DL) Out - Undisclosed. Z. Sandy (CB) Out - Undisclosed. C. Williams (DL) Out - Undisclosed. R. Brubaker (OG) Out - Undisclosed.

“I think we are a really good team when we play well. That’s how I feel. We have to play the game the right way. We were good enough tonight to hang in there. Part of that is talent, but I think it’s also resilience. We’re good enough to win games. We’re going to need to play better to do that in our league, but tonight, our resilience and our fight kept us within fighting distance.” - Clark Lea after his team’s win against VA Tech in their last game. 

“We know we have to be a lot better. We can’t rely on our defense and special teams to score three touchdowns a game." - Shane Beamer after his team’s win against SC State in their last game. 

WR Sherrill, Junior

WR Hudson, Trent

WR Richardson, Tre

TE Stowers, Eli

QB Pavia, Diego

RB Alexander, Sedrick

WR Harbor, Nyck

WR Rowe Jr., Brian

WR Bennett Jr., Mazeo

TE Hunt, Brady

QB Sellers, LaNorris

RB Faison, Rahsul

Passing: D. Pavia (468)

Rushing: S. Alexander (156)

Receiving: T. Richardson (128)

Touchdowns: S. Alexander (3)

Passing: L. Sellers (337)

Rushing: O. Adaway III (80)

Receiving: N. Harbor (99)

Touchdowns: N. Harbor (1)

Coaches:

Vanderbilt Commodores: Clark Lea (5th season)

South Carolina Gamecocks: Shane Beamer (5th season)