Vanderbilt Commodores vs Memphis Tigers Prediction, Picks and Game Preview - 12/17/2025

Game Time: 7:00 pm ET, Wednesday, December 17, 2025

Venue:  FedExForum, Memphis, TN

Where to Watch:  ESPN2

DraftKings:  Point Spread:  Vanderbilt -7.5, Memphis +7.5; Over/Under:  159.5 points

Bet365:  Point Spread:  Vanderbilt -7.5, Memphis +7.5; Over/Under:  159.5 points

BetMGM:  Point Spread:  Vanderbilt -7.5, Memphis +7.5; Over/Under:  159.5 points

Vanderbilt Commodores:  10-0 (0-0) (1st place, SEC)

Memphis Tigers:  4-5 (0-0) (11th place, American)

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Vanderbilt Commodores:  5-0  last 5

Memphis Tigers:  3-2  last 5

Vanderbilt is entering this game with a 10-0 record overall, a 0-0 record in conference games, and they are 1-0 in their road games this season where they will be in this game. They are coming off a win against the Central Arkansas Bears in their last game. Tyler Nickel led the team in points in that game with 30 while Tyler Tanner and Jalen Washington each were next on the team with 12. Tyler Tanner led the team in assists with 7 in that game while Devin McGlockton led the team in rebounds with 10. They were 42.2% from the field, 28.9% from 3-point range, and 81.8% from the free throw line with their shooting in that game. Their offense is averaging 95.4 PPG and their defense is allowing their opponents to average 72.9 PPG against them. Vanderbilt has an ATS record of 6-4 this season and their O/U record is 6-4.

Memphis is entering this game with a 4-5 record overall, a 0-0 conference record, and they are 4-1 in their home games this season where they will be in this game. They are coming off a loss against the Louisville Cardinals in their last game. Hasan Abdul Hakim led the team in points in that game with 18 while Dug McDaniel was next on the team with 16. Ashton Hardaway and Sincere Parker each led the team in assists with 3 in that game while Aaron Bradshaw led the team in rebounds with 5. They were 41.2% from the field, 27.3% from 3-point range, and 70% from the free throw line with their shooting in that game. Their offense is averaging 75.7 PPG and their defense is allowing their opponents to average 76.9 PPG against them. Memphis has an ATS record of 7-2 this season and their O/U record is 4-5.

The current betting odds have Vanderbilt listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. Vanderbilt has looked great in their games this season with their 10-0 record overall which has them right at the top of the SEC. They have been a good road team so far too, going 1-0 in their road games this year. Meanwhile, Memphis hasn't looked great in their games this season with their 4-5 record overall which has them right near the bottom of the American Conference. They have looked good on their home court though with their 4-1 home record this year. A lot of their losses have been on the road or in neutral site games, but they have also been getting blown out in a lot of their losses. They haven't had the strongest schedule to start the season either, but they haven't been able to compete with the few good teams they have played. They are off a big loss to Louisville in their last one too and they are right in the middle of a down year after having one of the best teams in this conference for years. Vanderbilt has had a great start to the season though, off a win over Central Arkansas in their last one, and they have been rolling over opponents this year. Vandy hasn't had a tough schedule to start the season either, but they have been beating up on teams and they look like one of the best teams in the SEC right now. Look for Vanderbilt to take advantage of this bad start to the season for Memphis and beat up on them while they are still trying to figure things out before conference play. The best way to place a bet here is on Vanderbilt to cover the spread in this game. 

Vanderbilt Memphis Prediction:  Our NCAAB Pick for Wednesday, December 17, 2025 (7:00 pm ET start time) is Vanderbilt 88 Memphis 71.

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Vanderbilt Commodores: 32-20 ATS as a road favorite or pick. 7-2 ATS as a road favorite of 6.5 to 12 points. 22-15 ATS in non-conference games. 33-26 UNDER versus good ball handling teams - committing 14 turnovers/game or less. 18-8 UNDER when playing only their 2nd game in 8 days.

Memphis Tigers: 3-6 ATS off a road loss. 7-18 ATS after playing a road game. 2-6 ATS versus teams who average 9 or more steals/game on the season. 7-4 UNDER after allowing 85 points or more. 3-0 UNDER as a home underdog or pick.

Vanderbilt Commodores:  G. Kimble (G) Out - Knee.

Memphis Tigers:  J. Thedford (G) Questionable - Knee. C. Givens (G) Questionable - Thigh.

"It was not easy scheduling, but I want this series for the fans. Teams in Tennessee like us should play each other, and they've got a great basketball tradition, and so we were willing to say we'll come to Memphis this year and start it on the road. That's how bad we want to start it. It should be a series that we play year in and year out." - Mark Byington on scheduling this game against Memphis. 

“Obviously, it's a terrible, terrible outcome for us with a week to prepare. Kudos to Louisville. Played a really good game, well-oiled machine. On both ends of the floor, they were the aggressor, and I'll just have to this as a coach and say my team wasn't as prepared as their team was, and we got a bad loss.” - Penny Hardaway after his team’s loss against Louisville in their last game. 

D. McGlockton 

D. Miles 

T. Nickel 

A. Okereke 

T. Tanner

A. Bradshaw 

C. Givens 

D. McDaniel 

S. Parker 

T. Sylla

PPG: Duke Miles (16.6)

APG: Frankie Collins (4.9)

Reb/G: Devin McGlockton (7)

PPG: Dug McDaniel (14.1)

APG: Dug McDaniel (5.7)

Reb/G: Julius Thedford (5.1)

Coaches:

Vanderbilt Commodores: Mark Byington (2nd season)

Memphis Tigers: Anfernee Hardaway (8th season)