UCLA Bruins vs Ohio State Buckeyes Prediction, Picks and Game Preview - 11/15/2025

Game Time: 7:30 pm ET, Saturday, November 15, 2025

Venue:  Ohio Stadium, Columbus, OH

Where to Watch:  NBC

DraftKings:  Point Spread:  UCLA +31.5, OSU -31.5; Over/Under:  47.5 points

Bet365:  Point Spread:  UCLA +32, OSU -32; Over/Under:  48.5 points

BetMGM:  Point Spread:  UCLA +31.5, OSU -31.5; Over/Under:  47.5 points

UCLA Bruins:  3-6 (3-3) (12th place, Big Ten)

Ohio State Buckeyes:  9-0 (6-0) (2nd place, Big Ten)

Do not miss out on our expert handicapper analysis! Vegas Writer is on a HOT STREAK in college football on a 7-1 CFB RUN for +$5,960 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

UCLA Bruins:  lost their last game at home against the Nebraska Cornhuskers 28-21.

Ohio State Buckeyes:  won their last game on the road against the Purdue Boilermakers 34-10.

UCLA is entering this game with a 3-6 record overall and they have a 3-3 record in their conference games too. They are 2-3 in their home games, 1-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Nebraska 28-21. Nico Iamaleava was the starting QB and he completed 17/25 passes for 191 passing yards, 2 touchdowns, and 0 interceptions. Nico Iamaleava led the team in rushing yards with 86. Rico Flores Jr. led the receivers with 52 receiving yards on 6 receptions. Key Lawrence led the defense in that game with 6 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them in that one. No one on the defense came away with an interception for them in that one.

 

 

 

Ohio State is entering this game with a 9-0 record overall and they have a 6-0 record in their conference games too. They are 5-0 in their home games, 4-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Purdue 34-10. Julian Sayin was the starting QB and he completed 27/33 passes for 303 passing yards, 1 touchdown, and 1 interception. Bo Jackson led the team in rushing yards with 75. Jeremiah Smith led the receivers with 137 receiving yards on 10 receptions and 1 TD. Payton Pierce led the defense in that game with 5 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. Jermaine Mathews Jr. came away with the only interception for them in that one.

The current betting odds have Ohio State listed as a 31.5 point favorite in this game according to Draftkings Sportsbook. Ohio State has looked great in their games this season with their 9-0 record overall and their 6-0 conference record which has them right near the top of the Big Ten. They are currently ranked 1st overall and are one of the few teams left in the nation still undefeated. Meanwhile, UCLA hasn't looked good in their games this season with their 3-6 record overall and their 3-3 conference record which has them in the middle of the Big Ten. Their season started as a disaster and they even fired their head coach. They ended up going on a bit of a run which ended Penn State's season as a ranked team, but that boost is gone now and they have lost 2 games in a row. They are off a 28-21 loss at home to Nebraska in their last one and they weren't competitive in their game against Indiana either, losing 56-6. UCLA has already shown that they don't have the talent to compete with the 2nd ranked team in the nation so they aren't going to have better luck on the road in this one. Ohio State has one of the best defenses in the nation this year, not giving up many points in their games at all, and they have been beating teams to sleep all season. UCLA won't be able to do much in this one as Ohio State pulls away throughout the game. The best way to place a bet here is on Ohio State to cover the spread in this game. 

UCLA Ohio State Prediction:  Our NCAAF Pick for Saturday, November 15, 2025 (7:30 pm ET start time) is Ohio State 42 UCLA 3.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this UCLA Bruins Ohio State Buckeyes prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

UCLA Bruins: 4-7 ATS vs. good passing teams averaging 250 or more passing yards/game. 0-3 ATS vs. good passing defenses - allowing 150 or less passing yards/game. 3-7 ATS in games played on turf. 23-11 UNDER in all lined games. 9-4 UNDER off a loss against a conference rival. 

Ohio State Buckeyes: 24-12 ATS in all lined games. 14-5 ATS as a home favorite. 8-1 ATS off a road win against a conference rival. 24-14 UNDER in all lined games. 18-7 UNDER against conference opponents. 15-6 UNDER off a win against a conference rival. 

UCLA Bruins:  J. Saint Paul (WR) Out - Undisclosed. M. Sultemeier (OG) Out - Undisclosed. D. Aupiu (DL) Out - Undisclosed. J. Marshall (WR) Out - Undisclosed. P. Clarkson (QB) Out - Undisclosed. N. Davillier (DL) Out - Undisclosed. B. Perry (LB) Out - Undisclosed. R. James III (DL) Out - Undisclosed. T. Partlow (DL) Out - Undisclosed. K. Arnold (OG) Out - Undisclosed. J. Jeffers (OG) Out - Undisclosed. K. Gordon (QB) Out - Undisclosed.

Ohio State Buckeyes:  C. Tate (WR) Questionable - Undisclosed. A. Tounkara (DL) Questionable - Undisclosed. M. Roy (DL) Questionable - Undisclosed. T. Rogers (RB) Questionable - Undisclosed. J. Padilla (OG) Questionable - Undisclosed. M. Maggs (QB) Questionable - Undisclosed. D. Jones (WR) Questionable - Undisclosed. M. Hartford (S) Questionable - Undisclosed. L. George (DL) Questionable - Undisclosed. P. Daniels (OG) Questionable - Undisclosed. Q. Porter (WR) Questionable - Undisclosed.

“Most of our game plan was to stop 21 (Johnson). He's a special, special player.” - Tim Skipper after his team’s loss against Nebraska in their last game.

“They're business-like, they're growing up every day. I think they’re edgy, they’re competitive, they know what they want to get done. They've seen it and they have some perspective on it.” - Ryan Day after his team’s win against Purdue in their last game. 

WR Gilmer, Kwazi

WR Flores Jr., Rico

WR Mokiao-Atimalala, Titus

TE Habermehl, Hudson

QB Iamaleava, Nico

RB Woods, Anthony

WR Tate, Carnell

WR Smith, Jeremiah

WR Inniss, Brandon

TE Klare, Max

QB Sayin, Julian

RB Jackson, Bo

Passing: Nico Iamaleava (1,659)

Rushing: Nico Iamaleava (474)

Receiving: Kwazi Gilmer (395)

Touchdowns: Nico Iamaleava (4)

Passing: Julian Sayin (2,491)

Rushing: Bo Jackson (613)

Receiving: Jeremiah Smith (862)

Touchdowns: Jeremiah Smith (11)

Coaches:

UCLA Bruins: Tim Skipper (Interim)

Ohio State Buckeyes: Ryan Day (8th season)