UCLA Bruins vs Indiana Hoosiers Prediction, Picks and Game Preview - 10/25/2025

Game Time: 12:00 pm ET, Saturday, October 25, 2025

Venue:  Indiana University Memorial Stadium, Bloomington, IN 

Where to Watch:  FOX

DraftKings:  Point Spread:  UCLA +24.5, Indiana -24.5; Over/Under:  54.5 points

Bet365:  Point Spread:  UCLA +24.5, Indiana -24.5; Over/Under:  54 points

BetMGM:  Point Spread:  UCLA +24.5, Indiana -24.5; Over/Under:  54.5 points

UCLA Bruins:  3-4 (3-1) (9th place, Big Ten)

Indiana Hoosiers:  7-0 (4-0) (1st place, Big Ten)

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UCLA Bruins:  won their last game at home against the Maryland Terrapins 20-17.

Indiana Hoosiers:  won their last game at home against the Michigan State Spartans 38-13.

UCLA is entering this game with a 3-4 record overall and they have a 3-1 record in their conference games too. They are 2-2 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Maryland 20-17. Nico Iamaleava was the starting QB and he completed 21/35 passes for 221 passing yards, 1 touchdown, and 2 interceptions. Anthony Frias II led the team in rushing yards with 97 and 1 TD. Titus Mokiao-Atimalala led the receivers with 102 receiving yards on 6 receptions. JonJon Vaughns led the defense in that game with 5 solo tackles and 3 assisted tackles while no one on the defense recorded a sack for them. Scooter Jackson came away with the only interception for them in that one.

 

 

 

Indiana is entering this game with a 7-0 record overall and they have a 4-0 record in their conference games too. They are 5-0 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Michigan State 38-13. Fernando Mendoza was the starting QB and he completed 24/28 passes for 332 passing yards, 4 touchdowns, and 0 interceptions. Kaelon Black led the team in rushing yards with 64 and 1 TD. Omar Cooper Jr. led the receivers with 115 receiving yards on 8 receptions and 1 TD. Louis Moore led the defense in that game with 10 solo tackles and 1 assisted tackle while Rolijah Hardy and Stephen Daley each led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

The current betting odds have Indiana listed as a 24.5 point favorite in this game according to Draftkings Sportsbook. Indiana has looked great in their games this season with their 7-0 record overall and their 4-0 conference record which has them right near the top of the Big Ten. They are ranked like one of the best teams in the nation at the moment and they have a really impressive win under their belt, on the road in Oregon 30-20. They have been rolling over opponents all season and they already had their trap game last week. They were coming back home after that big win in Oregon and they did get off to a slow start, but they found their rhythm in the game and still came away with a 38-13 win over Michigan State. Now they are going to be at home for a 2nd game in a row and they won't be overlooking this UCLA team that has had a recent resurgence. Meanwhile, UCLA hasn't looked great in their games this season with their 3-4 record overall, but their 3-1 conference record has them right in the middle of the Big Ten. They are off a 20-17 win over Maryland in their last one and they have been rolling over opponents since firing their head coach. UCLA has completely turned their season around now, but they are still facing one of the best teams in the nation and this is going to be a real test for them. UCLA has looked great lately against weaker opponents, but they still give up a ton of points on defense and they definitely don't have the offense to compete with Indiana here. The best way to place a bet here is on Indiana to cover the spread in this game. 

UCLA Indiana Prediction:  Our NCAAF Pick for Saturday, October 25, 2025 (12:00 pm ET start time) is Indiana 45 UCLA 13.

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UCLA Bruins: 3-8 ATS when the total is between 49.5 and 56. 3-6 ATS off a win against a conference rival. 3-6 ATS in games played on turf. 30-21 OVER after a win by 6 or less points. 33-21 OVER versus good defensive teams - allowing 4.5 yards/play or less.

Indiana Hoosiers: 20-12 ATS in all lined games. 13-7 ATS as a favorite. 7-2 ATS off a home win by 17 points or more. 14-4 ATS after playing a game at home. 21-11 OVER in all lined games. 6-3 OVER in a home game where the total is between 49.5 and 56. 14-4 OVER after playing a game at home. 

UCLA Bruins:  A. Sanders (DL) Questionable - Undisclosed. J. Johnson (CB) Questionable - Undisclosed. C. Stewart (CB) Questionable - Undisclosed. J. Marshall (WR) Questionable - Undisclosed. B. Perry (LB) Questionable - Undisclosed. P. Clarkson (QB) Questionable - Undisclosed. N. Davillier (DL) Questionable - Undisclosed. R. Stafford III (CB) Questionable - Undisclosed. K. Clark (CB) Questionable - Undisclosed. R. James III (DL) Out - Undisclosed. T. Partlow (DL) Out - Undisclosed. K. Arnold (OG) Out - Undisclosed. J. Jeffers (OG) Out - Undisclosed. K. Gordon (QB) Out - Undisclosed.

Indiana Hoosiers:  B. Bonds (CB) Out - Undisclosed. L. Beebe Jr. (RB) Out - Leg. T. Morris (WR) Out - Knee.

“I think it's all about belief, (and) the guys believe. There's nothing that happened throughout the game that's going to take our confidence away, and you don't really know that until you get in a tight game like that. I found out today that these guys believe.” - Tim Skipper after his team’s win against Maryland in their last game. 

"This is the sharpest we've seen him up to this point in a game. And he continues to improve. He continues to prepare like nobody I've ever been around. He's getting better and better." - Curt Cignetti after his team’s win against MSU in their last game. 

WR Gilmer, Kwazi

WR Flores Jr., Rico

WR Mokiao-Atimalala, Titus

TE Habermehl, Hudson

QB Iamaleava, Nico

RB Woods, Anthony

WR Sarratt, Elijah

WR Williams Jr., E.J.

WR Cooper Jr., Omar

TE Nowakowski, Riley

QB Mendoza, Fernando

RB Hemby, Roman

Passing: Nico Iamaleava (1,355)

Rushing: Nico Iamaleava (360)

Receiving: Kwazi Gilmer (369)

Touchdowns: Nico Iamaleava (4)

Passing: Fernando Mendoza (1,755)

Rushing: Kaelon Black (439)

Receiving: Elijah Sarratt (603)

Touchdowns: Elijah Sarratt (9)

Coaches:

UCLA Bruins: Tim Skipper (Interim)

Indiana Hoosiers: Curt Cignetti (2nd season)