Tulane Green Wave vs Mississippi Rebels Prediction, Picks and Game Preview - 12/20/2025

Game Time: 3:30 pm ET, Saturday, December 20, 2025

Venue:  Vaught Hemingway Stadium, Oxford, MS

Where to Watch:  TNT, HBO MAX, truTV

DraftKings:  Point Spread:  Tulane +17.5, Ole Miss -17.5; Over/Under:  56.5 points

Bet365:  Point Spread:  Tulane +17.5, Ole Miss -17.5; Over/Under:  56.5 points

BetMGM:  Point Spread:  Tulane +17.5, Ole Miss -17.5; Over/Under:  56.5 points

Tulane Green Wave:  11-2 (7-1) (1st place, American)

Mississippi Rebels:  11-1 (7-1) (3rd place, SEC)

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Tulane Green Wave:  won their last game at home against the North Texas Mean Green 34-21.

Mississippi Rebels:  won their last game on the road against the Mississippi State Bulldogs 38-19.

Tulane is entering this game with an 11-2 record overall and they have a 7-1 record in their conference games too. They are 7-0 in their home games, 4-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against North Texas 34-21. Jake Retzlaff was the starting QB and he completed 13/22 passes for 145 passing yards, 0 touchdowns, and 0 interceptions. Jamauri McClure led the team in rushing yards with 121 and 1 TD. Garrett Mmahat led the receivers with 39 receiving yards on 3 receptions. Jack Tchienchou led the defense in that game with 8 solo tackles and 1 assisted tackle while Santana Hopper led the defense in sacks with 2. Chris Rodgers, Jack Tchienchou, and Jahiem Johnson each came away with 1 interception for them in that one.

 

 

 

Ole Miss is entering this game with an 11-1 record overall and they have a 7-1 record in their conference games too. They are 8-0 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Mississippi State 38-19. Trinidad Chambliss was the starting QB and he completed 23/34 passes for 359 passing yards, 4 touchdowns, and 0 interceptions. Kewan Lacy led the team in rushing yards with 143 and 1 TD. Deuce Alexander led the receivers with 94 receiving yards on 2 receptions and 1 TD. Andrew Jones led the defense in that game with 4 solo tackles and 4 assisted tackles while Da'Shawn Womack, Will Echoles, and Princewill Umanmielen each led the defense in sacks with 1. Princewill Umanmielen came away with the only interception for them in that one.

The current betting odds have Ole Miss listed as a 17.5 point favorite in this game according to Draftkings Sportsbook. Ole Miss has looked really good in their games this season with their 11-1 record overall and their 7-1 conference record which had them right near the top of the SEC. They have looked great on their home field too with their 8-0 home record this year. Meanwhile, Tulane has looked great in their games this season with their 11-2 record overall and their 7-1 conference record which had them right at the top of the American Conference. They have been a good road team too with their 4-2 road record this year, but their only 2 losses this season did come in road games. Tulane had a great end to the regular season as they overcame a bad loss to UTSA and still managed to get to the American Conference Championship and win it all. They are off a big win over North Texas in that game and that was a great win, but they still don't have the talent to compete with Ole Miss. Ole Miss wasn't able to get to the SEC Championship due to their 1 loss which came against Georgia, but they had a great year and ended it with a big road win over Mississippi State. They did lose their head coach to the LSU job and won't have him for this game, but Tulane also lost their head coach too. Sumrall is still coaching Tulane in this one, but he is going to have distractions with his new job, and these two already played each other earlier this season which didn't go well for Tulane. Ole Miss won at home 45-10 and even though Tulane has improved a lot since that game, so has Ole Miss so they aren't going to be able to close that gap with the talent they have. The best way to place a bet here is on Ole Miss to cover the spread in this game. 

Tulane Mississippi Prediction:  Our NCAAF Pick for Saturday, December 20, 2025 (3:30 pm ET start time) is Ole Miss 42 Tulane 17.

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Tulane Green Wave: 0-4 ATS against SEC opponents. 0-4 ATS as an underdog of 10.5 to 21 points. 3-6 ATS vs. good passing teams averaging 8 or more passing yards/att. 23-13 UNDER in all lined games. 6-0 UNDER when the total is between 56.5 and 63.

Mississippi Rebels: 22-14 ATS in all lined games. 8-4 ATS in a home game where the total is between 56.5 and 63. 11-3 ATS in non-conference games. 21-10 UNDER as a favorite. 11-6 UNDER off a win against a conference rival.

Tulane Green Wave:  D. Jackson (CB) Questionable - Undisclosed. C. Helmke (K) Questionable - Undisclosed. J. Lewis (CB) Questionable - Undisclosed. B. Sullivan (QB) Questionable - Undisclosed. M. Turner (RB) Questionable - Undisclosed. C. Klein (S) Questionable - Undisclosed. G. Henderson (DL) Out - Undisclosed. L. Husbands (TE) Out - Undisclosed. T. Thompson (TE) Out - Knee. D. Agu (LB) Out - Undisclosed.

Mississippi Rebels:  A. Kite (CB) Questionable - Undisclosed. R. Collins (LB) Questionable - Undisclosed.

“Just excited for these guys and selfishly grateful I get to work two jobs a little bit longer. I’m just cherishing every moment and trying to make sure I appreciate every interaction and every play.” - Jon Sumrall after his team’s win against the UNT in the American Conference Championship.

“It’s an unbelievable job by these players. We only returned two starters from last year, so, for these guys to overcome adversity throughout the year, play really well — they played a great second half today. I’m just happy for our fans, for our players. All the stuff they dealt with all week from outside people saying they were distracted, there was noise. This is what these guys do. They’ve been doing it for a long time. I think it actually brings them together and they play (well) because of all the stuff outside.” - Lane Kiffin after Ole Miss beat Mississippi State in their regular season finale. 

WR Preston, Shazz

WR Brown-Stephens, Anthony

WR Bohanon, Bryce

TE Pascuzzi, Johnny

QB Retzlaff, Jake

RB Gordon, Javin

WR Stribling, De'Zhaun

WR Wallace III, Harrison

WR Lee, Cayden

TE Wright, Dae'Quan

QB Chambliss, Trinidad

RB Lacy, Kewan

Passing: Jake Retzlaff (2,862)

Rushing: Jake Retzlaff (610)

Receiving: Shazz Preston (598)

Touchdowns: Jake Retzlaff (16)

Passing: Trinidad Chambliss (3,016)

Rushing: Kewan Lacy (1,279)

Receiving: Harrison Wallace III (719)

Touchdowns: Kewan Lacy (20)

Coaches:

Tulane Green Wave: Jon Sumrall (2nd season)

Mississippi Rebels: Pete Golding (Interim)