Tulane Green Wave vs Mississippi Rebels Prediction, Picks and Game Preview - 09/20/2025

Game Time: 3:30 pm ET, Saturday, September 20, 2025

Venue:  Vaught Hemingway Stadium, Oxford, MS

Where to Watch:  ESPN

DraftKings:  Point Spread:  Tulane +11.5, Ole Miss -11.5; Over/Under:  61.5 points

Bet365:  Point Spread:  Tulane +11.5, Ole Miss -11.5; Over/Under:  61 points

BetMGM:  Point Spread:  Tulane +11.5, Ole Miss -11.5; Over/Under:  61.5 points

Tulane Green Wave:  3-0 (0-0) (4th place, American)

Mississippi Rebels:  3-0 (2-0) (1st place, SEC)

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Tulane Green Wave:  won their last game at home against the Duke Blue Devils 34-27.

Mississippi Rebels:  won their last game at home against the Arkansas Razorbacks 41-35.

Tulane is entering this game with a 3-0 record overall and they have a 0-0 record in their conference games too. They are 2-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Duke 34-27. Jake Retzlaff was the starting QB and he completed 15/23 passes for 245 passing yards, 0 touchdowns, and 0 interceptions. Jake Retzlaff led the team in rushing yards with 111 and 4 TDs. Shazz Preston led the receivers with 95 receiving yards on 3 receptions. Dickson Agu led the defense in that game with 6 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. Javion White came away with the only interception for them in that one.

 

 

 

Ole Miss is entering this game with a 3-0 record overall and they have a 2-0 record in their conference games too. They are 2-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Arkansas 41-35. Trinidad Chambliss was the starting QB and he completed 21/29 passes for 353 passing yards, 1 touchdown, and 0 interceptions. Trinidad Chambliss led the team in rushing yards with 62 and 2 TDs. Harrison Wallace III led the receivers with 92 receiving yards on 6 receptions and 1 TD. Wydett Williams Jr. led the defense in that game with 6 solo tackles and 0 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

The current betting odds have Tulane listed as an 11.5 point underdog in this game according to Draftkings Sportsbook. Tulane has looked great in their games this season with their 3-0 record overall which has them right at the top of the American and trying to establish themselves as the power in the group of 5. They already have 2 great wins against power conference teams, beating Northwestern and Duke, and that offense has looked great in their last 2 games. Meanwhile, Ole Miss has looked great in their games this season with their 3-0 record overall and their 2-0 conference record which has them right at the top of the SEC with an early jump on the rest of the conference. They won a tough game in Kentucky and are now off a high scoring win against Arkansas in their last one, but both of those wins came in 1 score games. Their offense has looked great this season and they looked even better last week with Chambliss taking over for Simmons, but their defense has been terrible with the points they have been giving up. Tulane doesn't have the talent that Ole Miss has, but they do have a really good offense with a lot of talent that will be able to put up points on this Ole Miss defense and keep the game close. The best way to place a bet here is on Tulane to cover the spread in this game. 

Tulane Mississippi Prediction:  Our NCAAF Pick for Saturday, September 20, 2025 (3:30 pm ET start time) is Ole Miss 31 Tulane 21.

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Tulane Green Wave: 1-4 ATS as an underdog. 0-3 ATS against SEC opponents. 3-7 ATS versus good offensive teams - averaging 5.9 yards/play or more. 4-0 UNDER when the total is between 56.5 and 63. 10-4 UNDER after 3 or more consecutive straight up wins.

Mississippi Rebels: 17-10 ATS in all lined games. 10-5 ATS in home lined games. 10-1 ATS in non-conference games. 6-2 UNDER as a favorite of 10.5 to 21 points. 8-3 UNDER after scoring 37 points or more last game.

Tulane Green Wave:  M. Turner (RB) Questionable - Ankle. T. Thompson (TE) Questionable - Knee.

Mississippi Rebels:  J. Braxton (CB) Questionable - Undisclosed. T. Ray (WR) Questionable - Undisclosed.

“The analytics tell you to go there, but I felt like it was a critical part of the game. We wanted to have a pass/run option, or Jake could go thumbs down and we … punt.” - Jon Sumrall after his team’s win against Duke in their last game. 

“Great job by Trinidad, obviously, and a great job by our coaches getting our backup quarterback ready. Trinidad really took care of the ball, got out of trouble all night and only got sacked once.” - Lane Kiffin after his team’s win against Arkansas in their last game. 

WR Preston, Shazz

WR Bohanon, Bryce

WR Hayes, Omari 

TE Miller, Anthony

QB Retzlaff, Jake

RB Turner, Maurice

WR Wallace III, Harrison

WR Stribling, De'Zhaun

WR Lee, Cayden

TE Wright, Dae'Quan

QB Simmons, Austin

RB Lacy, Kewan

Passing: J. Retzlaff (522)

Rushing: J. Retzlaff (288)

Receiving: O. Hayes (143)

Touchdowns: J. Retzlaff (6)

Passing: A. Simmons (580)

Rushing: K. Lacy (290)

Receiving: H. Wallace III (339)

Touchdowns: K. Lacy (5)

Coaches:

Tulane Green Wave: Jon Sumrall (2nd season)

Mississippi Rebels: Lane Kiffin (6th season)