Troy Trojans vs Clemson Tigers Prediction, Picks and Game Preview - 09/06/2025

Game Time: 3:30 pm ET, Saturday, September 6, 2025

Venue:  Memorial Stadium, Clemson, SC

Where to Watch:  ACC Network

DraftKings:  Point Spread:  Troy +33.5, Clemson -33.5; Over/Under:  51.5 points

Bet365:  Point Spread:  Troy +33.5, Clemson -33.5; Over/Under:  51.5 points

BetMGM:  Point Spread:  Troy +33.5, Clemson -33.5; Over/Under:  51.5 points

Troy Trojans:  1-0 (0-0) (4th place, Sun Belt West)

Clemson Tigers:  0-1 (0-0) (14th place, ACC)

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Troy Trojans:  won their last game at home against the Nicholls State Colonels 38-20.

Clemson Tigers:  lost their last game at home against the LSU Tigers 17-10.

Troy is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Nicholls State 38-20. Will Crowder was the starting QB and he completed 14/24 passes for 144 passing yards, 3 touchdowns, and 0 interceptions. Tae Meadows led the team in rushing yards with 186 and 1 TD. Roman Mothershed led the receivers with 32 receiving yards on 2 receptions and 1 TD. Jaquez White led the defense in that game with 6 solo tackles and 2 assisted tackles while Donnie Smith, Devin Lafayette, and Luis Medina each led the defense in sacks with 1. Jaquez White came away with the only interception for them in that one.

 

 

 

Clemson is entering this game with a 0-1 record overall and they have a 0-0 record in their conference games too. They are 0-1 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against LSU 17-10. Cade Klubnik was the starting QB and he completed 19/38 passes for 230 passing yards, 0 touchdowns, and 1 interception. Adam Randall led the team in rushing yards with 16 and 1 TD. Bryant Wesco Jr. led the receivers with 66 receiving yards on 4 receptions. Myles Graham led the defense in that game with 4 solo tackles and 1 assisted tackle while Will Heldt led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Clemson listed as a 33.5 point favorite in this game according to Draftkings Sportsbook. Clemson is 0-1 overall after losing their season opener at home. They lost their season opener to LSU 17-10 and they didn't look good in that game. They only lost that game by 1 TD, but that score could have been much worse as they were completely outplayed in the 2nd half. Their defense looked good as they were able to hold up against a really good LSU offense, keeping Clemson in the game, but the offense stalled in the 2nd half and could barely move the ball. Now they will be at home again here, but they are playing against a much lesser opponent so they will be looking to take out their frustrations from that loss. Meanwhile, Troy is 1-0 overall after winning their season opener at home, but they weren't really tested at all. They beat a team from the FCS at home, beating Nicholls State 38-20, and their defense didn't look that good. They gave up 20 points at home to an offense that doesn't have nearly as much talent, and now they are going on the road against an angry Clemson team coming off a loss. Clemson is going to shred this defense for a lot of points at home and they won't take their foot off the gas with the way their offense looked last week. Their defense also looked great against a really strong LSU offense so this Troy offense isn't going to do much on the road here. The best way to place a bet here is on Clemson to cover the spread in this game. 

Troy Clemson Prediction:  Our NCAAF Pick for Saturday, September 6, 2025 (3:30 pm ET start time) is Clemson 52 Troy 3.

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Troy Trojans: 8-4 ATS in road lined games. 8-4 ATS when the total is between 49.5 and 56. 9-5 ATS after 1 or more consecutive straight up wins. 8-4 UNDER when the total is between 49.5 and 56. 9-3 UNDER after playing a game at home.

Clemson Tigers: 3-6 ATS in non-conference games. 6-11 ATS in games played on a grass field. 12-7 UNDER as a favorite. 9-5 UNDER after playing a game at home. 

Troy Trojans:  None.

Clemson Tigers:  W. Parks (OG) Questionable - Undisclosed. J. Haynes (RB) Questionable - Knee. A. Williams (WR) Questionable - Hamstring. J. Preston (WR) Questionable - Hamstring. J. Green (RB) Out - Foot.

“We’ll build on what we can and the history of what Troy historically has done and discuss those things, and then obviously be truthful as well, but this roster is loaded. This is a different roster than the team we played at Iowa and certainly anything that we’ve played since I’ve been here and even better than some of the Clemson teams I’ve been a part of when I’ve played as an assistant coach. So we have our hands full. Our players will know that and understand that turning the film on, but we’ll certainly celebrate also us going to go compete and do what our program stands for in doing so and make sure and push to our players as we prepare for them.” - Gerad Parker on his team’s upcoming game against Clemson this week.

“We didn’t play anywhere near where we are capable of playing on offense. We have to own that.” - Dabo Swinney after his team’s loss against LSU in their last game. 

WR Mothershed, Roman

WR Dortch, Mojo

WR Higgins, Peyton

TE Conner, Ethan

QB Crowder, Goose

RB Cooley, Trey

WR Moore, T.J. 

WR Wesco Jr., Bryant

WR Williams, Antonio

TE Patt-Henry, Olsen

QB Klubnik, Cade

RB Randall, Adam

Passing: G. Crowder (144)

Rushing: T. Meadows (186)

Receiving: R. Mothershed (32)

Touchdowns: G. Crowder (1)

Passing: C. Klubnik (230)

Rushing: A. Randall (16)

Receiving: B. Wesco Jr. (66)

Touchdowns: A. Randall (1)

Coaches:

Troy Trojans: Gerad Parker (2nd season)

Clemson Tigers: Dabo Swinney (18th season)