Toronto Blue Jays vs Seattle Mariners Prediction, Preview and Odds - 10/15/2025

Game Time: 8:08 pm ET, Wednesday, October 15, 2025

Venue:  T-Mobile Park, Seattle, WA 

Where to Watch:  Fox Sports 1

DraftKings:  Moneyline odds:  Blue Jays +112, Mariners -137; Over/Under:  7 runs

Bet365:  Moneyline odds:  Blue Jays +115, Mariners -135; Over/Under:  7 runs

BetMGM:  Moneyline odds:  Blue Jays +115, Mariners -135; Over/Under:  7 runs

Toronto Blue Jays:  94-68 (1st place, AL East)

Seattle Mariners:  90-72 (1st place, AL West)

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Toronto Blue Jays:  7-3 last 10

Seattle Mariners:  5-5 last 10

The Blue Jays are entering this series off a win and won their best of 5-game series against the New York Yankees 3-1 in the American League Division Series. They finished the regular season with a 94-68 record overall and had a road record of 40-41. This is the 3rd game of a best 4 out of 7 game series with the Mariners on Wednesday for the American League Championship Series. Their offense ranks 3rd in the MLB with a .760 OPS. Rookie pitcher Trey Yesavage was their starting pitcher on Monday while Shane Bieber is making his start in this game on Wednesday. He is 4-2 with a 3.57 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB start, he allowed 2 ER, 0 HR, and 1 BB with 2 Ks on 5 hits through 2.2 IP against the New York Yankees.

The Mariners are entering this series off a win and won their best of 5-game series against the Detroit Tigers 3-2 in the ALDS. They finished the regular season with a 90-72 record overall and had a home record of 51-30. This is the 3rd game of a best 4 out of 7 game series with the Blue Jays on Wednesday for the ALCS. Their offense ranks 10th in the MLB with a .740 OPS. Logan Gilbert was their starting pitcher on Monday while George Kirby is making his start in this game on Wednesday. He is 10-8 with a 4.21 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB start, he allowed 1 earned run, 0 homers, and 0 BB with 6 strikeouts on 3 hits through 5 innings played against the Detroit Tigers.

The current betting odds have the Mariners listed as a favorite in this game according to Draftkings Sportsbook. The Mariners have a 2-0 series lead after winning game 2 of this series in Toronto. They took both road games to start this series and now have 3 games in a row at home to close this series out. Their pitching has been really good in this series and throughout the playoffs, but now their offense has really been rolling too. Kirby is on the mound for the Mariners in this one and he has looked good this season. He is 10-8 with a 4.21 ERA, but lately he hasn't been giving up many runs at all. He only gave up 1 earned run in his last start against the Tigers and he has looked a lot better in his home starts this season too. Meanwhile, the Blue Jays are going with Bieber in this one and he has looked good this season too. He is 4-2 with a 3.57 ERA, but lately he has been giving up more runs in his starts. He gave up 2 earned runs in his last start against the Yankees and he was giving up more runs toward the end of the regular season too. The team has also lost 2 of their last 3 games with him starting, and the Mariners have the much hotter offense to rely on too. The Blue Jays have a lot of pressure as the team with the home advantage that has now been flipped in the Mariners favor and this series will likely not get back to Toronto with the momentum on the Mariners side. The best way to place a bet here is on the Mariners to win this game. 

Blue Jays Mariners Prediction:  Our MLB Pick for Wednesday, October 15, 2025 (8:08 pm ET start time) is Mariners 5 Blue Jays 2.

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Toronto Blue Jays: 55-42 (+5.7 units) on the moneyline against AL West opponents. 81-87 (+9.1 units) on the moneyline as an underdog of +100 to +150. 23-16 (+6.5 units) on the moneyline after allowing 10 runs or more. 21-15 OVER on the road when playing against a team with a winning record.

Seattle Mariners: 38-57 (-24.5 units) on the moneyline against AL East opponents. 128-107 (-7.4 units) on the moneyline when the money line is -100 to -150. 190-164 (-7.9 units) on the moneyline against right-handed starters. 22-10 OVER after scoring 10 runs or more.

Toronto Blue Jays:  A. Santander (RF) Day To Day - Back. J. Berrios (SP) Fifteen Day IL - Elbow. T. France (1B) Ten Day IL - Oblique. B. Bichette (SS) Ten Day IL - Knee. R. Pina (SP) Sixty Day IL - Elbow. N. Sandlin (RP) Sixty Day IL - Elbow. Y. Garcia (RP) Sixty Day IL - Ankle. B. Francis (SP) Sixty Day IL - Shoulder. R. Burr (RP) Sixty Day IL - Shoulder. A. Bastardo (SP) Sixty Day IL - Elbow.

Seattle Mariners:  J. Kowar (RP) Fifteen Day IL - Shoulder. T. Thornton (RP) Sixty Day IL - Achilles. G. Santos (RP) Sixty Day IL - Knee. R. Bliss (2B) Sixty Day IL - Biceps.

"I’m always going to have optimism about this team. We’ve got to figure out a way to limit damage, one, and then, two, generate more offense.” - John Schneider after his team’s loss against the Mariners in game 2 of this series on Monday.

“We can’t get complacent. We’ve got to keep the edge, keep the fire underneath us, and take it one day at a time.” - J.P. Crawford after their win against the Blue Jays in game 2 of this series on Monday.

George Springer (R) DH

Nathan Lukes (L) RF

Vladimir Guerrero Jr. (R) 1B

Addison Barger (L) 3B

Alejandro Kirk (R) C

Daulton Varsho (L) CF

Ernie Clement (R) 2B

Davis Schneider (R) LF

Andrés Giménez (L) SS

Randy Arozarena (R) LF

Cal Raleigh (S) C

Julio Rodríguez (R) CF

Jorge Polanco (S) 2B

Josh Naylor (L) 1B

Eugenio Suárez (R) 3B

Dominic Canzone (L) DH

Victor Robles (R) RF

J.P. Crawford (L) SS

Batting Average:  Joey Loperfido (.333)

Hits:  Bo Bichette (181)

Home Runs:  George Springer (32)

RBI:  Bo Bichette (94)

Stolen Bases:  George Springer (18)

Wins:  Chris Bassitt (11)

Saves:  Jeff Hoffman (33)

ERA:  Ryan Burr (0.00)

Batting Average:  Dominic Canzone (.300)

Hits:  Julio Rodríguez (174)

Home Runs:  Cal Raleigh (60)

RBI:  Cal Raleigh (125)

Stolen Bases:  Randy Arozarena (31)

Wins:  Bryan Woo (15)

Saves:  Andrés Muñoz (38)

ERA:  Jhonathan Díaz (0.00)

Managers:

Toronto Blue Jays: John Schneider (4th season)

Seattle Mariners: Dan Wilson (2nd season)