Toronto Blue Jays vs New York Yankees Prediction, Preview and Odds - 09/06/2025

Game Time: 1:05 pm ET, Saturday, September 6, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Blue Jays +118, Yankees -144; Over/Under:  9 runs

Bet365:  Moneyline odds:  Blue Jays +120, Yankees -140; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Blue Jays +120, Yankees -140; Over/Under:  9 runs

Toronto Blue Jays:  81-59 (1st place, AL East)

New York Yankees:  78-62 (2nd place, AL East)

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Toronto Blue Jays:  5-5 last 10

New York Yankees:  8-2 last 10

The Blue Jays are entering this series off a win and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with an 81-59 record overall and have a road record of 36-35. This is the 2nd game of a 3-game series with the Yankees on Saturday with the series opener still to be played on Friday. Their offense ranks 2nd in the MLB with a .774 OPS. Kevin Gausman is their starting pitcher on Friday while Max Scherzer is making his start in this game on Saturday. He is 5-2 with a 4.11 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 2 HR, and 0 BB with 1 SO on 9 hits through 4 IP against the Milwaukee Brewers.

The Yankees are entering this series off a win and won their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 78-62 record overall and have a home record of 41-28. This is the 2nd game of a 3-game series with the Blue Jays on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 1st in the MLB with a .789 OPS. Rookie pitcher Cam Schlittler is their starting pitcher on Friday while Luis Gil is making his start in this game on Saturday. He is 2-1 with a 3.68 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 2 walks with 7 strikeouts on 4 hits through 5.1 innings pitched against the Chicago White Sox.

The current betting odds have the Blue Jays listed as an underdog in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 78-62 record overall which has them right near the top of the AL East. They have also looked great in their own ballpark this year with their 41-28 home record. Meanwhile, the Blue Jays have looked great in their games this season with their 81-59 record overall which has them right at the top of the AL East. They haven't been a great road team though with their 36-35 road record this season. The Yankees have been rolling in their games lately as they are 8-2 in their last 10, but the Blue Jays have been putting up a ton of runs lately and they have an offense that can go toe-to-toe with the Yankees. Gil is on the mound for the Yankees in this one and he has looked good this season. He is 2-1 with a 3.68 ERA, but he hasn't been a solid starter for the Yankees. He only gave up 2 earned runs in his last start, but he has been up and down all season and the team has lost 2 of their last 3 games with him starting too. The Blue Jays are going with Scherzer in this one and he hasn't looked great this season. He is 5-2 with a 4.11 ERA and has been giving up more runs this year, but he is a solid veteran starter and has looked a lot better lately. He did give up 4 earned runs in his last start, but he will be looking to bounce back with a better performance and the team has still won 4 games in a row now with him starting. The Yankees have been rolling lately, but this isn't a strong starter for them and the Blue Jays offense can take advantage of that so there is value with the Blue Jays as the underdog in a tight division race right now. The best way to place a bet here is on the Blue Jays to win this game. 

Blue Jays Yankees Prediction:  Our MLB Pick for Saturday, September 6, 2025 (1:05 pm ET start time) is Blue Jays 7 Yankees 5.

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Toronto Blue Jays: 70-52 (+6.1 units) on the moneyline vs. a team with a poor bullpen whose ERA is 4.20 or worse. 137-126 (+6.6 units) on the moneyline when playing against a team with a winning record. 55-48 (+8.1 units) on the moneyline vs. AL teams scoring 4.9 or more runs/game on the season. 33-16 OVER vs. an AL team with a slugging percentage of .440 or better on the season.

New York Yankees: 261-216 (-26.7 units) on the moneyline in all games. 131-107 (-28.6 units) on the moneyline in home games. 65-78 (-30.3 units) on the moneyline against division opponents. 40-26 OVER when playing against a team with a winning record. 

Toronto Blue Jays:  R. Pina (SP) Sixty Day IL - Elbow. N. Sandlin (RP) Sixty Day IL - Elbow. Y. Garcia (RP) Sixty Day IL - Ankle. B. Francis (SP) Sixty Day IL - Shoulder. R. Burr (RP) Sixty Day IL - Shoulder. A. Santander (RF) Sixty Day IL - Shoulder. A. Manoah (SP) Sixty Day IL - Elbow. A. Bastardo (SP) Sixty Day IL - Elbow.

New York Yankees:  J. Chisholm Jr. (2B) Day To Day - Leg. B. Headrick (RP) Fifteen Day IL - Forearm. A. Slater (LF) Ten Day IL - Hamstring. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

“I think to me, the key at-bat was George. After we're down five, that was an unbelievable swing to hit it out to dead center, and he's been doing it all year. And I'll say it now, I think he deserves MVP consideration. I don't want to put the cart before the horse, but I mean this dude’s hitting over .300 with 27 [homers], [72] RBIs and [.956] OPS. This guy’s playing his [butt] off.” - John Schneider after his team’s win against the Reds in their game on Wednesday.

"I thought he threw great today. With all those righties, I thought he used his changeup so well, and he had a good fastball to go with it. I thought he was really good even deep into the outing. I thought he was almost getting sharper.” - Aaron Boone after his team’s win against the Astros in their game on Thursday.

George Springer (R) LF

Addison Barger (L) RF

Vladimir Guerrero Jr. (R) DH

Bo Bichette (R) SS

Daulton Varsho (L) CF

Alejandro Kirk (R) C

Ty France (R) 1B

Andrés Giménez (L) 2B

Ernie Clement (R) 3B

Trent Grisham (L) CF

Ben Rice (L) 1B

Aaron Judge (R) DH

Cody Bellinger (L) RF

Giancarlo Stanton (R) LF

Jazz Chisholm Jr. (L) 2B

Austin Wells (L) C

Anthony Volpe (R) SS

Ryan McMahon (L) 3B

Batting Average:  Joey Loperfido (.358)

Hits:  Bo Bichette (177)

Home Runs:  George Springer (27)

RBI:  Bo Bichette (91)

Stolen Bases:  George Springer (16)

Wins:  Chris Bassitt (11)

Saves:  Jeff Hoffman (30)

ERA:  Ryan Burr (0.00)

Batting Average:  Amed Rosario (.389)

Hits:  Aaron Judge (152)

Home Runs:  Aaron Judge (43)

RBI:  Aaron Judge (97)

Stolen Bases:  Jazz Chisholm (26)

Wins:  Carlos Rodón (16)

Saves:  Devin Williams (18)

ERA:  Adam Ottavino (0.00)

Managers:

Toronto Blue Jays: John Schneider (4th season)

New York Yankees: Aaron Boone (8th season)