Toronto Blue Jays vs New York Yankees Prediction, Preview and Odds - 09/05/2025

Game Time: 7:05 pm ET, Friday, September 5, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Blue Jays +112, Yankees -137; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Blue Jays +115, Yankees -135; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Blue Jays +115, Yankees -135; Over/Under:  8.5 runs

Toronto Blue Jays:  81-59 (1st place, AL East)

New York Yankees:  77-62 (2nd place, AL East)

Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in the MLB on a 49-32-2 MLB RUN for +$13,310 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Toronto Blue Jays:  5-5 last 10

New York Yankees:  8-2 last 10

The Blue Jays are entering this series off a win and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with an 81-59 record overall and have a road record of 36-35. This is the series opener of a 3-game series with the Yankees on Friday and they have Thursday off as a day of rest. Their offense ranks 2nd in the MLB with a .774 OPS. Shane Bieber was their starting pitcher on Wednesday while Kevin Gausman is making his start in this game on Friday. He is 8-10 with a 3.75 ERA this season. His team lost their last 4 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 0 BB with 8 SO on 4 hits through 7 IP against the Milwaukee Brewers.

The Yankees won their 4-game series against the Chicago White Sox 3-1. They enter this game with a 77-62 record overall and have a home record of 41-28. This is the 1st game of a 3-game series with the Blue Jays on Friday with the series finale of their series against the Houston Astros still to be played on Thursday. The Yankees won the 1st game of that series on Tuesday and lost the 2nd game on Wednesday. Their offense ranks 1st in the MLB with a .789 OPS. Carlos Rodón is their starting pitcher on Thursday while rookie pitcher Cam Schlittler is making his start in this game on Friday. He is 2-2 with a 2.61 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 8 strikeouts on 4 hits through 6 innings pitched against the Chicago White Sox.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 77-62 record overall which has them right near the top of the AL East. They have also looked great in their own ballpark this year with their 41-28 home record. Meanwhile, the Blue Jays have looked great in their games this season with their 81-59 record overall which has them right at the top of the AL East. They haven't been a great road team though with their 36-35 road record this season. The Blue Jays have been putting up a ton of runs lately, but so have the Yankees and the Yankees have been rolling lately as they are 8-2 in their last 10 while the Blue Jays are only 5-5. The Yankees also have the better pitching matchup in this one and can take advantage of that. The Yankees are going with Schlittler in this one and he has looked good in his rookie year. He is 2-2 with a 2.61 ERA and has been getting better as the season goes on. He is coming off another great start in which he only gave up 1 earned run and the team has won 3 games in a row now with him starting too. The Blue jays are going with Gausman in this one and he has looked good this season. He is 8-10 with a 3.75 ERA, but he has also been really up and down this year with those 10 losses. He only gave up 1 earned run in his last start, but the team hasn't had a lot of success with him lately, losing 4 games in a row now with him as the starter. The Yankees are rolling right now and they are definitely trying to catch the Blue Jays in 1st place so they will bring their best effort for this series and all signs point to the Yankees in this one. The best way to place a bet here is on the Yankees to win this game. 

Blue Jays Yankees Prediction:  Our MLB Pick for Friday, September 5, 2025 (7:05 pm ET start time) is Yankees 5 Blue Jays 4.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Toronto Blue Jays New York Yankees prediction, be sure to drop by every day for our daily MLB projections and previews.

Toronto Blue Jays: 70-52 (+6.1 units) on the moneyline vs. a team with a poor bullpen whose ERA is 4.20 or worse. 137-126 (+6.6 units) on the moneyline when playing against a team with a winning record. 55-48 (+8.1 units) on the moneyline vs. AL teams scoring 4.9 or more runs/game on the season. 33-16 OVER vs. an AL team with a slugging percentage of .440 or better on the season.

New York Yankees: 260-216 (-27.7 units) on the moneyline in all games. 131-107 (-28.6 units) on the moneyline in home games. 65-78 (-30.3 units) on the moneyline against division opponents. 39-26 OVER when playing against a team with a winning record. 

Toronto Blue Jays:  R. Pina (SP) Sixty Day IL - Elbow. N. Sandlin (RP) Sixty Day IL - Elbow. Y. Garcia (RP) Sixty Day IL - Ankle. B. Francis (SP) Sixty Day IL - Shoulder. R. Burr (RP) Sixty Day IL - Shoulder. A. Santander (RF) Sixty Day IL - Shoulder. A. Manoah (SP) Sixty Day IL - Elbow. A. Bastardo (SP) Sixty Day IL - Elbow.

New York Yankees:  B. Headrick (RP) Fifteen Day IL - Forearm. A. Slater (LF) Ten Day IL - Hamstring. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

“I think to me, the key at-bat was George. After we're down five, that was an unbelievable swing to hit it out to dead center, and he's been doing it all year. And I'll say it now, I think he deserves MVP consideration. I don't want to put the cart before the horse, but I mean this dude’s hitting over .300 with 27 [homers], [72] RBIs and [.956] OPS. This guy’s playing his [butt] off.” - John Schneider after his team’s win against the Reds in their game on Wednesday.

"Obviously, a tough inning. Thought [Devin] was throwing the ball well. Real competitive at-bats -- even the walks. A lot of close pitches. They got the best of us tonight. We had a lead, a couple chances to add on, and I thought the Astros put some really good at-bats together, really squaring up some pitches against us the second half of the game.” - Aaron Boone after his team’s loss against the Astros in their game on Wednesday.

George Springer (R) LF

Addison Barger (L) RF

Vladimir Guerrero Jr. (R) DH

Bo Bichette (R) SS

Daulton Varsho (L) CF

Alejandro Kirk (R) C

Ty France (R) 1B

Andrés Giménez (L) 2B

Ernie Clement (R) 3B

Trent Grisham (L) CF

Aaron Judge (R) DH

Cody Bellinger (L) RF

Jazz Chisholm Jr. (L) 2B

Giancarlo Stanton (R) LF

Ben Rice (L) 1B

Austin Wells (L) C

Anthony Volpe (R) SS

Ryan McMahon (L) 3B

Batting Average:  Joey Loperfido (.358)

Hits:  Bo Bichette (177)

Home Runs:  George Springer (27)

RBI:  Bo Bichette (91)

Stolen Bases:  George Springer (16)

Wins:  Chris Bassitt (11)

Saves:  Jeff Hoffman (30)

ERA:  Ryan Burr (0.00)

Batting Average:  Amed Rosario (.389)

Hits:  Aaron Judge (152)

Home Runs:  Aaron Judge (43)

RBI:  Aaron Judge (97)

Stolen Bases:  Jazz Chisholm (26)

Wins:  Carlos Rodón (15)

Saves:  Devin Williams (18)

ERA:  Adam Ottavino (0.00)

Managers:

Toronto Blue Jays: John Schneider (4th season)

New York Yankees: Aaron Boone (8th season)