Texas Rangers vs Houston Astros Prediction, Preview and Odds - 09/17/2025

Game Time: 8:10 pm ET, Wednesday, September 17, 2025

Venue:  Daikin Park, Houston, TX

Where to Watch:  Rangers Sports Network, SCHN

DraftKings:  Moneyline odds:  Rangers -126, Astros +104; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Rangers -125, Astros +105; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Rangers -125, Astros +105; Over/Under:  7.5 runs

Texas Rangers:  79-72 (3rd place, AL West)

Houston Astros:  82-69 (2nd place, AL West)

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Texas Rangers:  7-3 last 10

Houston Astros:  5-5 last 10

The Rangers are entering this series off a loss and won their 3-game series against the New York Mets 2-1 in their last series. They enter this game with a 79-72 record overall and have a road record of 32-44. This is the series finale of a 3-game series with the Astros on Wednesday with the 2nd game still to be played on Tuesday. The Rangers lost the series opener on Monday. Their offense ranks 25th in the MLB with a .693 OPS. Merrill Kelly is their starting pitcher on Tuesday while Jacob deGrom is making his start in this game on Wednesday. He is 12-7 with a 2.82 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 1 HR, and 0 BB with 2 SO on 4 hits through 7 IP against the New York Mets.

The Astros are entering this series off a loss and won their 3-game series against the Atlanta Braves 2-1 in their last series. They enter this game with an 82-69 record overall and have a home record of 44-32. This is the 3rd game of a 3-game series with the Rangers on Wednesday with the 2nd game of this series still to be played on Tuesday. The Astros won the 1st game of this series on Monday. Their offense ranks 13th in the MLB with a .718 OPS. Rookie pitcher AJ Blubaugh is their starting pitcher on Tuesday while Cristian Javier is making his start in this game on Wednesday. He is 1-3 with a 4.78 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 1 homer, and 1 walk with 6 strikeouts on 6 hits through 6 innings pitched against the Toronto Blue Jays.

The current betting odds have the Rangers listed as slight favorite in this game according to Draftkings Sportsbook. The Rangers have looked good in their games this season with their 79-72 record overall which has them right in the middle of the AL West and in the Wild Card race. They haven't been a great road team though with their 32-44 road record this season. Meanwhile, the Astros have looked great in their games this season with their 82-69 record overall which has them right near the top of the AL West and in the division race. They have also looked great in their own ballpark this year with their 44-32 home record. The Astros haven't looked great lately though, going 5-5 in their last 10 games while the Rangers have been hot going 7-3, and the Rangers have the better pitching matchup to take advantage of in this one. The Rangers are going with deGrom in this one and he has looked great this season. He is 12-7 with a 2.82 ERA and he hasn't been giving up many runs lately. He did give up 3 earned runs in his last start, but that hasn't been a common theme for him and the team has still won 2 of their last 3 games with him starting. Javier is on the mound for the Astros in this one and he hasn't been great this season. He is 1-3 with a 4.78 ERA and has struggled since coming back from an injury that kept him out a lot of the year. He is coming off another bad start in which he gave up 4 earned runs and the team has lost 2 games in a row now with him starting too. The Astros may have the better offense here, but the Rangers have a big edge with these starters as they also have the better bullpen. The best way to place a bet here is on the Rangers to win this game. 

Rangers Astros Prediction:  Our MLB Pick for Wednesday, September 17, 2025 (8:10 pm ET start time) is Rangers 4 Astros 1.

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Texas Rangers: 195-170 (+7.7 units) on the moneyline against right-handed starters. 40-33 (+6.3 units) on the moneyline vs. a starting pitcher who gives up 0.5 or less HR's/start. 109-81 (+11.4 units) on the moneyline vs. AL teams scoring 4.4 or less runs/game on the season. 38-20 UNDER when the money line is -100 to -150.

Houston Astros: 267-219 (-12.3 units) on the moneyline in all games. 130-115 (-40.5 units) on the moneyline in home games. 84-68 (-5.1 units) on the moneyline against division opponents. 29-20 UNDER vs. an AL starting pitcher whose WHIP is 1.300 or better.

Texas Rangers:  J. Gray (SP) Sixty Day IL - Shoulder. D. Coulombe (RP) Fifteen Day IL - Shoulder. C. Seager (SS) Ten Day IL - Appendectomy. E. Carter (CF) Sixty Day IL - Wrist. N. Eovaldi (SP) Fifteen Day IL - Rotator Cuff. M. Semien (2B) Ten Day IL - Foot. S. Haggerty (CF) Ten Day IL - Oblique. T. Mahle (SP) Sixty Day IL - Shoulder. C. Bradford (RP) Sixty Day IL - Elbow. J. Sborz (RP) Sixty Day IL - Shoulder.

Houston Astros:  Y. Alvarez (LF) Day To Day - Ankle. L. McCullers Jr. (SP) Fifteen Day IL - Hand. L. Garcia (SP) Sixty Day IL - Elbow. K. Ort (RP) Fifteen Day IL - Elbow. S. Arrighetti (SP) Fifteen Day IL - Elbow. J. Rooney (SP) Sixty Day IL - Concussion / Nasal. B. Sousa (RP) Fifteen Day IL - Elbow. B. Walter (RP) Sixty Day IL - Elbow. J. Hader (RP) Fifteen Day IL - Shoulder. I. Paredes (3B) Sixty Day IL - Hamstring. B. Rodgers (2B) Sixty Day IL - Oblique. Z. Dezenzo (RF) Sixty Day IL - Hand. P. Leon (RF) Sixty Day IL - Knee. R. Blanco (SP) Sixty Day IL - Elbow. H. Wesneski (RP) Sixty Day IL - Elbow.

“It wasn't our cleanest game.” - Bruce Bochy after his team’s loss against the Astros in their game on Monday.

“That was a fastball well-executed. Leiter put that pitch where he wanted to, and this kid just put an ‘A’ swing on it. He continues to do things that show he’s well prepared. The stage is not fazing him. And I’ve got to give him credit, because we’re in the middle of a race, and this kid is showing up.” - Joe Espada after his team’s win against the Rangers in their game on Monday.

Josh Smith (L) SS

Wyatt Langford (R) CF

Joc Pederson (L) DH

Jake Burger (R) 1B

Adolis García (R) RF

Alejandro Osuna (L) LF

Josh Jung (R) 3B

Jonah Heim (S) C

Dylan Moore (R) 2B

Jeremy Peña (R) SS

Yordan Alvarez (L) LF

Carlos Correa (R) 3B

Jose Altuve (R) 2B

Christian Walker (R) 1B

Jake Meyers (R) CF

Victor Caratini (S) DH

Yainer Diaz (R) C

Jesús Sánchez (L) RF

Batting Average:  Dylan Moore (.316)

Hits:  Josh Smith (122)

Home Runs:  Corey Seager (21)

RBI:  Adolis García (73)

Stolen Bases:  Wyatt Langford (19)

Wins:  Jacob deGrom (12)

Saves:  Shawn Armstrong (9)

ERA:  Carl Edwards (0.00)

Batting Average:  Zach Cole (.462)

Hits:  Jose Altuve (146)

Home Runs:  Jose Altuve (25)

RBI:  Christian Walker (81)

Stolen Bases:  Jeremy Peña (20)

Wins:  Framber Valdez (12)

Saves:  Josh Hader (28)

ERA:  Jayden Murray (0.00)

Managers:

Texas Rangers: Bruce Bochy (3rd season)

Houston Astros: Joe Espada (2nd season)