by Rod Pearson
Friday, Oct 24, 2025
Game Time: 4:25 pm ET, Sunday, October 26, 2025
Venue: Lucas Oil Stadium, Indianapolis, IN
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Titans +14.5, Colts -14.5; Over/Under: 47.5 points
Bet365: Point Spread: Titans +14.5, Colts -14.5; Over/Under: 47.5 points
BetMGM: Point Spread: Titans +14.5, Colts -14.5; Over/Under: 47.5 points
Season Record
Tennessee Titans: 1-6 (4th place, AFC South)
Indianapolis Colts: 6-1 (1st place, AFC South)
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Recent Form
Tennessee Titans: lost their last game at home against the New England Patriots 31-13.
Indianapolis Colts: won their last game on the road against the Los Angeles Chargers 38-24.
Tennessee Titans vs Indianapolis Colts Preview and Analysis
The Titans are entering this game with a 1-6 record overall and they have a 0-2 record in their divisional games too. They are 0-3 in their home games, 1-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the New England Patriots 31-13. Cameron Ward was the starting QB and he completed 25/34 passes for 255 passing yards, 1 touchdown, and 1 interception. Tyjae Spears led the team in rushing yards with 22. Chimere Dike led the receivers with 70 receiving yards on 4 receptions and 1 TD. Cedric Gray led the defense in that game with 7 solo tackles and 3 assisted tackles while Jihad Ward, T'Vondre Sweat, Dre'Mont Jones, and Xavier Woods each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Colts are entering this game with a 6-1 record overall and they have a 1-0 record in their divisional games too. They are 4-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Los Angeles Chargers 38-24. Daniel Jones was the starting QB and he completed 23/34 passes for 288 passing yards, 2 touchdowns, and 0 interceptions. Jonathan Taylor led the team in rushing yards with 94 and 3 TDs. Alec Pierce led the receivers with 98 receiving yards on 5 receptions. Nick Cross led the defense in that game with 6 solo tackles and 0 assisted tackles while DeForest Buckner led the defense in sacks with 2. Nick Cross and Grover Stewart each came away with 1 interception for them in that one.
Titans vs Colts Prediction
The current betting odds have the Colts listed as a 14.5 point favorite in this game according to Draftkings Sportsbook. The Colts have looked great in their games this season with their 6-1 record overall which has them right at the top of the AFC South with the best record in the entire NFL. Their only loss this season was on the road against a good Rams team, but that was a game they could have won too since they did shoot themselves in the foot multiple times. They have been rolling in every other game this season, off a 38-24 win over the Chargers in their last one too, and they already obliterated the Titans in Tennessee earlier this season. Meanwhile, the Titans have looked terrible in their games this season with their 1-6 record overall which has them right at the bottom of the AFC South with one of the worst records in the entire NFL. They are off a 31-13 loss to the Patriots in their last one and they have been getting blown out in their losses all season. Their defense hasn't looked terrible at times, but they can only do so much in these games with the offense not being able to stay on the field. The offense has struggled to put points on the board all season so they aren't going to be able to compete with this Colts offense that has been one of the best in the NFL this season. All signs point to another disappointing game for the Titans as the Colts continue to roll. The best way to place a bet here is on the Colts to cover the spread in this game.
Titans Colts Prediction: Our NFL Pick for Sunday, October 26, 2025 (4:25 pm ET start time) is Colts 45 Titans 10.
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NFL Betting Trends
Tennessee Titans: 11-29 ATS in all games. 6-14 ATS as a road underdog. 2-12 ATS versus division opponents. 1-8 ATS vs. good offensive teams - scoring 24 or more points/game. 7-2 OVER vs. good offensive teams - scoring 24 or more points/game. 10-3 OVER after scoring 14 points or less last game.
Indianapolis Colts: 7-3 ATS as a home favorite. 20-9 ATS against conference opponents. 6-2 ATS vs. poor offensive teams - scoring 17 or less points/game. 14-7 OVER in home games. 9-4 OVER versus division opponents.
Key Injuries
Tennessee Titans: B. Oliver (WR) Injured - Knee. J. Hekker (P) Injured - Illness. X. Woods (S) Injured - Ankle. J. Ward (LB) Injured - NIR - Rest. C. Ridley (WR) Injured - Hamstring. S. Joseph-Day (DL) Injured - Calf. A. Key (LB) Injured - Quadricep. J. Lynch (DL) Injured - Shoulder. K. Zeitler (OG) Injured - NIR - Rest. T. Pollard (RB) Injured - NIR - Rest. J. Simmons (DL) Injured - Hamstring. B. Hance (OG) Injured - Shoulder. L. Sneed (CB) Injured - Quadricep.
Indianapolis Colts: G. Stewart (DL) Injured - NIR-Rest. K. Moore II (CB) Injured - Achilles. S. Ebukam (DL) Injured - Knee. B. Smith (OT) Injured - NIR - Rest. T. Lewis (DL) Injured - Groin. A. Dulin (WR) Injured - Chest. T. Goodson (RB) Injured - Groin. J. Downs (WR) Injured - Concussion. J. Jones (CB) Injured - Hamstring.
Notable Quotes
“We’re going to stick together here. We're going to fight our tails off and find a way to go win the next one. That’s the most important thing.” - Mike McCoy after his team’s loss against the Patriots in their last game.
“It’s great to come back here. I got a lot of great memories here.” - Shane Steichen after his team’s win against the LA Chargers in their last game.
Starting Lineups
Tennessee Titans
WR Ayomanor, Elic
WR Jefferson, Van
WR Dike, Chimere
TE Helm, Gunnar
QB Ward, Cam
RB Pollard, Tony
Indianapolis Colts
WR Pittman Jr., Michael
WR Pierce, Alec
WR Gould, Anthony
TE Warren, Tyler
QB Jones, Daniel
RB Taylor, Jonathan
Statistical Leaders
Tennessee Titans
Passing: Cam Ward (1,356)
Rushing: Tony Pollard (380)
Receiving: Calvin Ridley (290)
Touchdowns: Elic Ayomanor (2)
Indianapolis Colts
Passing: Daniel Jones (1,790)
Rushing: Jonathan Taylor (697)
Receiving: Tyler Warren (439)
Touchdowns: Jonathan Taylor (11)
Coaches:
Tennessee Titans: Mike McCoy (Interim)
Indianapolis Colts: Shane Steichen (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
