Tennessee Titans vs Houston Texans Prediction, Preview and Odds - 09/28/2025

Game Time: 1:00 pm ET, Sunday, September 28, 2025

Venue:  NRG Stadium, Houston, TX

Where to Watch:  CBS

DraftKings:  Point Spread:  Titans +7, Texans -7; Over/Under:  38.5 points

Bet365:  Point Spread:  Titans +7, Texans -7; Over/Under:  38.5 points

BetMGM:  Point Spread:  Titans +7, Texans -7; Over/Under:  38.5 points

Tennessee Titans:  0-3 (4th place, AFC South)

Houston Texans:  0-3 (3rd place, AFC South)

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Tennessee Titans:  lost their last game at home against the Indianapolis Colts 41-20.

Houston Texans:  lost their last game on the road against the Jacksonville Jaguars 17-10.

The Titans are entering this game with a 0-3 record overall and they have a 0-1 record in their divisional games too. They are 0-2 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Indianapolis Colts 41-20. Cameron Ward was the starting QB and he completed 23/38 passes for 219 passing yards, 1 touchdown, and 1 interception. Tony Pollard led the team in rushing yards with 45 and 1 TD. Chigoziem Okonkwo led the receivers with 66 receiving yards on 5 receptions. Xavier Woods and Cody Barton each led the defense in that game with 5 solo tackles and 1 assisted tackle while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

The Texans are entering this game with a 0-3 record overall and they have a 0-1 record in their divisional games too. They are 0-1 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Jacksonville Jaguars 17-10. C. J. Stroud was the starting QB and he completed 25/38 passes for 204 passing yards, 1 touchdown, and 2 interceptions. Nick Chubb led the team in rushing yards with 38. Nico Collins led the receivers with 104 receiving yards on 8 receptions and 1 TD. Kamari Lassiter led the defense in that game with 5 solo tackles and 0 assisted tackles while Will Anderson Jr. led the defense in sacks with 1. Jalen Pitre came away with the only interception for them in that one.

The current betting odds have the Texans listed as a 7 point favorite in this game according to Draftkings Sportsbook. The Texans have looked terrible in their games this season with their 0-3 record overall which has them right near the bottom of the AFC South. As bad as they have looked, they haven't had an easy schedule to start the season and all 3 of their losses were in close games. Their offense has looked terrible this season, but their defense has looked great, keeping them in a lot of their games, and this is going to be a great chance for that offense to have a get right game at home. Meanwhile, the Titans have looked terrible in their games this season with their 0-3 record overall which has them right near the bottom of the AFC South. They were the worst team in the NFL last season, picking Cam Ward number 1 overall in the draft, but they look like they are going to be the worst team in the NFL once again. Cam Ward hasn't looked terrible, but he has a lot of work to do before becoming a true NFL starter so the Texans defense can take advantage of this Titans offense that has made many mistakes in their 3 games already. This is a game where the Texans should roll over the Titans and pick up their first win of the season with ease. The best way to place a bet here is on the Texans to cover the spread in this game. 

Titans Texans Prediction:  Our NFL Pick for Sunday, September 28, 2025 (1:00 pm ET start time) is Texans 23 Titans 13.

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Tennessee Titans: 10-26 ATS in all games. 3-14 ATS as an underdog of 3.5 to 9.5 points. 2-11 ATS versus division opponents. 4-0 UNDER when playing against a terrible team (Win Pct. <=25%). 4-0 UNDER versus poor offensive teams - averaging 285 yards/game or less.

Houston Texans: 8-4 ATS in all games where the total is between 35.5 and 42 points. 8-2 ATS after playing a division game. 7-2 ATS versus poor rushing defenses - allowing 4.5 rushing yards/carry or more. 25-14 UNDER in all games. 9-2 UNDER as a home favorite of 7 points or less.

Tennessee Titans:  K. Zeitler (OG) Injured - Bicep. J. Latham (OT) Injured - Hip. K. Mullings (RB) Injured - Ankle. B. Oliver (WR) Injured - Knee. C. Ward (QB) Injured - Ankle. K. Winston Jr. (S) Injured - Hamstring.

Houston Texans:  N. Collins (WR) Injured - Knee. D. Stingley Jr. (CB) Injured - Oblique. J. Johnson (FB) Injured - Hamstring. J. Andrews (C) Injured - Ankle. T. Howard (OT) Injured - Illness.

“If I was them, I'd be mad too.” - Cam Ward on the fans booing after their loss against the Colts in their last game. 

“We give the ball to one of our best players, Nico. We trust him with the football. He knows it. I know he hates it more than anyone else, to have the ball taken away from him there. That was tough.” - DeMeco Ryans after his team’s loss against the Jags in their last game. 

WR Ayomanor, Elic

WR Ridley, Calvin

WR Lockett, Tyler

TE Okonkwo, Chig

QB Ward, Cam

RB Pollard, Tony

WR Collins, Nico

WR Higgins, Jayden

WR Kirk, Christian

TE Schultz, Dalton

QB Stroud, C.J.

RB Chubb, Nick

FB Johnson, Jakob

Passing: Cam Ward (506)

Rushing: Tony Pollard (197)

Receiving: Chig Okonkwo (120)

Touchdowns: Elic Ayomanor (2)

Passing: C.J. Stroud (599)

Rushing: Nick Chubb (141)

Receiving: Nico Collins (181)

Touchdowns: Nico Collins (2)

Coaches:

Tennessee Titans: Brian Callahan (2nd season)

Houston Texans: DeMeco Ryans (3rd season)