Tennessee Titans vs Denver Broncos Prediction, Preview and Odds - 09/07/2025

Game Time: 4:05 pm ET, Sunday, September 7, 2025

Venue:  Empower Field at Mile High, Denver, CO

Where to Watch:  FOX

DraftKings:  Point Spread:  Titans +8.5, Broncos -8.5; Over/Under:  42.5 points

Bet365:  Point Spread:  Titans +8.5, Broncos -8.5; Over/Under:  42.5 points

BetMGM:  Point Spread:  Titans +8, Broncos -8; Over/Under:  42.5 points

Tennessee Titans:  0-0 (AFC South)

Denver Broncos:  0-0 (AFC West)

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Tennessee Titans:  N/A

Denver Broncos:  N/A

The Titans finished last season with a 3-14 record overall and they were 1-5 in their division games too. They had a 1-7 record in their home games and had a 2-7 record in their road games where they will be in this game. Last season, their offense was averaging 18.3 points per game and their defense was allowing an average of 27.1 points per game. Their offense was also averaging 304.2 yards per game and their defense was allowing an average of 311.2 yards per game. Will Levis led the team in passing yards with 2,091, Tony Pollard led the team in rushing yards with 1,079, and Calvin Ridley led the team in receiving yards with 1,017.

The Broncos finished last season with a 10-7 record overall and they were 3-3 in their division games too. They had a 6-2 record in their home games and had a 4-5 record in their road games where they will be in this game. Last season, their offense was averaging 25 points per game and their defense was allowing an average of 18.3 points per game. Their offense was also averaging 324.6 yards per game and their defense was allowing an average of 317.1 yards per game. Bo Nix led the team in passing yards with 3,775, Javonte Williams led the team in rushing yards with 513, and Courtland Sutton led the team in receiving yards with 1,081.

The current betting odds have the Broncos listed as an 8.5 point favorite in this game according to Draftkings Sportsbook. The Broncos had a great season last year with their rookie QB, going 10-7 overall and even making a playoff appearance. Sean Payton finally has his guy at QB now and the team will be looking to take a big step with Bo Nix in his 2nd season. They picked up Dobbins who should help their run game which wasn't great last season, and they still have a ton of talent on defense which was one of the best defenses in the NFL last year. Meanwhile, the Titans were terrible last season, finishing 3-14 overall and getting the number 1 draft pick as they were the worst team in the NFL last season. They ended up drafting Cam Ward to be their new starting QB and he was great in college, putting up big numbers with Miami last season, but this is going to be a big jump to the NFL and this is not an easy first game to play on the road in Denver. Denver is definitely one of the toughest places to play for a rookie QB so the offense isn't going to just transform in 1 game after being one of the worst offenses in the NFL last season. They also had one of the worst defenses in the NFL last season too so the Broncos are going to put up points on them and it will be very difficult for Ward to respond against this Broncos defense. This is a big mismatch to open up the season and the Broncos should have no issues pulling away throughout this game. The best way to place a bet here is on the Broncos to cover the spread in this game. 

Titans Broncos Prediction:  Our NFL Pick for Sunday, September 7, 2025 (4:05 pm ET start time) is Broncos 38 Titans 13.

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Tennessee Titans: 9-24 ATS in all games. 4-13 ATS in road games. 2-12 ATS as an underdog of 3.5 to 9.5 points. 5-0 OVER as a road underdog of 7.5 to 14 points. 

Denver Broncos: 11-5 ATS as a favorite. 11-6 ATS in all games where the total is between 35.5 and 42 points. 12-5 OVER in all games where the total is between 35.5 and 42 points. 4-1 OVER as a favorite of 3.5 to 9.5 points.

Tennessee Titans:  None.

Denver Broncos:  None.

"Consistency, he's shown up in practices, he's shown up in games. He's strong, he's fast, he's made plays when the ball comes his way." - Brian Callahan on Elic Ayomanor earning the right to be a starter. 

"He was having a real good spring, kind of an accelerated spring before the injury. It’s always frustrating for a player like that that has that type of setback as he’s trying to make the roster. He’s participating now. He’s developmental, he’s long, he’s got good strong hands. So we’ve been encouraged, and it’s good to have him back on the field healthy.” - Sean Payton on A.T. Perry working his way back from an injury.

WR Ayomanor, Elic

WR Ridley, Calvin

WR Lockett, Tyler

TE Okonkwo, Chig

QB Ward, Cam

RB Pollard, Tony

WR Sutton, Courtland

WR Mims Jr., Marvin

WR Franklin, Troy

TE Engram, Evan

QB Nix, Bo

RB Dobbins, J.K.

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Tennessee Titans: Brian Callahan (2nd season)

Denver Broncos: Sean Payton (3rd season)