Tennessee Titans vs Arizona Cardinals Prediction, Preview and Odds - 10/05/2025

Game Time: 4:05 pm ET, Sunday, October 5, 2025

Venue:  State Farm Stadium, Glendale, AZ

Where to Watch:  CBS

DraftKings:  Point Spread:  Titans +7.5, Cardinals -7.5; Over/Under:  42.5 points

Bet365:  Point Spread:  Titans +7.5, Cardinals -7.5; Over/Under:  42 points

BetMGM:  Point Spread:  Titans +7.5, Cardinals -7.5; Over/Under:  42 points

Tennessee Titans:  0-4 (4th place, AFC South)

Arizona Cardinals:  2-2 (4th place, NFC West)

Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in the NFL on a 27-19-1 NFL RUN for +$6,300 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Tennessee Titans:  lost their last game on the road against the Houston Texans 26-0.

Arizona Cardinals:  lost their last game at home against the Seattle Seahawks 23-20.

The Titans are entering this game with a 0-4 record overall and they have a 0-2 record in their divisional games too. They are 0-2 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Houston Texans 26-0. Cameron Ward was the starting QB and he completed 10/26 passes for 108 passing yards, 0 touchdowns, and 1 interception. Tony Pollard led the team in rushing yards with 64. Elic Ayomanor led the receivers with 44 receiving yards on 2 receptions. Cedric Gray led the defense in that game with 10 solo tackles and 7 assisted tackles while Jeffery Simmons and Arden Key each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Cardinals are entering this game with a 2-2 record overall and they have a 0-2 record in their divisional games too. They are 1-1 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Seattle Seahawks 23-20. Kyler Murray was the starting QB and he completed 27/41 passes for 200 passing yards, 2 touchdowns, and 2 interceptions. Kyler Murray led the team in rushing yards with 41. Marvin Harrison Jr. led the receivers with 66 receiving yards on 6 receptions and 1 TD. Jalen Thompson led the defense in that game with 5 solo tackles and 4 assisted tackles while Calais Campbell, Darius Robinson, and Josh Sweat each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have the Cardinals listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. The Cardinals haven't looked great in their games this season with their 2-2 record overall which has them right at the bottom of the NFC West. They started the season 2-0 with wins over the Saints and the Panthers, but now they have lost 2 games in a row against better opponents. They played 2 tight games in those losses though and now they are back at home with a chance to bounce back against one of the worst teams in the NFL. The Cardinals also played last Thursday so they have had some extra time to get ready for this game. Meanwhile, the Titans have looked terrible in their games this season with their 0-4 record overall which has them right at the bottom of the AFC South. They played a good season opener against the Broncos, but it has all been downhill since then with 3 blow out losses in a row. They are also coming off a 26-0 loss in their last one, getting completely shut out, so they have no momentum on their side going into this one. The Titans are shaping up to be one of the worst teams in the NFL again and they are going to struggle to keep this game close against a Cardinals team looking to bounce back at home after 2 losses in a row. The best way to place a bet here is on the Cardinals to cover the spread in this game. 

Titans Cardinals Prediction:  Our NFL Pick for Sunday, October 5, 2025 (4:05 pm ET start time) is Cardinals 31 Titans 7.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Tennessee Titans Arizona Cardinals prediction, be sure to drop by every day for our weekly NFL predictions and previews.

Tennessee Titans: 10-27 ATS in all games. 5-14 ATS in road games. 3-6 ATS after 3 or more consecutive losses against the spread. 4-13 ATS after playing their last game on the road. 5-1 OVER as a road underdog of 7.5 to 14 points. 8-3 OVER after scoring 14 points or less last game.

Arizona Cardinals: 8-2 ATS in non-conference games. 8-4 ATS after 2 or more consecutive losses. 4-1 ATS vs. poor passing defenses - allowing 7 or more passing yards/att. 5-1 OVER as a home favorite. 11-5 OVER in a home game where the total is between 42.5 and 49 points. 

Tennessee Titans:  M. Brown (S) Injured - Knee. B. Hance (OG) Injured - Shoulder. J. Latham (OT) Injured - Hip. J. Lynch (DL) Injured - Shoulder. B. Oliver (WR) Injured - Knee. T. Pollard (RB) Injured - NIR-Rest. C. Ridley (WR) Injured - Knee. J. Simmons (DL) Injured - NIR-Rest. T. Spears (RB) Injured - Ankle. K. Winston Jr. (S) Injured - Hamstring. K. Zeitler (OG) Injured - Foot.

Arizona Cardinals:  K. Beachum (OG) Injured - Rest. E. Brown (OG) Injured - Hamstring. G. Dortch (WR) Injured - Collarbone. S. Fehoko (WR) Injured - Concussion. J. Gaines II (OG) Injured - Finger. W. Hernandez (OG) Injured - Knee. Z. Jones (WR) Injured - Concussion. B. Nichols (DL) Injured - Neck. W. Johnson (CB) Injured - Groin. D. Robinson (DL) Injured - Pectoral.

“At this point we have nothing to lose. We dropped a quarter of our games, and we have yet to do anything, so we have to lock in, especially myself.” - Cam Ward after their loss against the Texans in their last game. 

“I appreciate the resiliency, that's there. No one has their head down. Everyone believes we can win. But we're not doing enough, all three phases, to win these games. That's very clear.” - Jonathan Gannon after his team’s loss against the Seahawks in their last game. 

WR Ayomanor, Elic

WR Ridley, Calvin

WR Lockett, Tyler

TE Okonkwo, Chig

QB Ward, Cam

RB Pollard, Tony

WR Harrison Jr., Marvin

WR Wilson, Michael 

WR Dortch, Greg

TE McBride, Trey

QB Murray, Kyler

RB Demercado, Emari

Passing: Cam Ward (614)

Rushing: Tony Pollard (261)

Receiving: Elic Ayomanor (151)

Touchdowns: Elic Ayomanor (2)

Passing: Kyler Murray (742)

Rushing: Trey Benson (160)

Receiving: Trey McBride (234)

Touchdowns: James Conner (2)

Coaches:

Tennessee Titans: Brian Callahan (2nd season)

Arizona Cardinals: Jonathan Gannon (3rd season)