TCU Horned Frogs vs Houston Cougars Prediction, Picks and Game Preview - 11/22/2025

Game Time: 4:00 pm ET, Saturday, November 22, 2025

Venue:  TDECU Stadium, Houston, TX

Where to Watch:  FOX

DraftKings:  Point Spread:  TCU +1.5, Houston -1.5; Over/Under:  55.5 points

Bet365:  Point Spread:  TCU +1, Houston -1; Over/Under:  55 points

BetMGM:  Point Spread:  TCU +1.5, Houston -1.5; Over/Under:  55.5 points

TCU Horned Frogs:  6-4 (3-4) (9th place, Big 12)

Houston Cougars:  8-2 (5-2) (4th place, Big 12)

Do not miss out on our expert handicapper analysis! Brian Bitler is on a HOT STREAK in college football on an 8-1 CFB RUN for +$6,900 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

TCU Horned Frogs:  lost their last game on the road against the BYU Cougars 44-13.

Houston Cougars:  won their last game on the road against the Central Florida Knights 30-27.

TCU is entering this game with a 6-4 record overall and they have a 3-4 record in their conference games too. They are 4-1 in their home games, 2-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against BYU 44-13. Josh Hoover was the starting QB and he completed 10/23 passes for 183 passing yards, 0 touchdowns, and 0 interceptions. Jeremy Payne led the team in rushing yards with 55. Eric McAlister led the receivers with 107 receiving yards on 4 receptions. Vernon Glover led the defense in that game with 5 solo tackles and 2 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

Houston is entering this game with an 8-2 record overall and they have a 5-2 record in their conference games too. They are 3-2 in their home games, 5-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against UCF 30-27. Conner Weigman was the starting QB and he completed 20/31 passes for 223 passing yards, 2 touchdowns, and 3 interceptions. Conner Weigman led the team in rushing yards with 82. Amare Thomas led the receivers with 103 receiving yards on 5 receptions and 1 TD. Jordan Allen led the defense in that game with 4 solo tackles and 0 assisted tackles while Carmycah Glass led the defense in sacks with 1. Latreveon McCutchin and Kentrell Webb each came away with 1 interception for them in that one.

The current betting odds have Houston listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. Houston has looked really good in their games this season with their 8-2 record overall and their 5-2 conference record which has them right near the top of the Big 12. They have been quietly putting together a great season in the Big 12 and now they are finally ranked inside the top 25. Meanwhile, TCU has looked good in their games this season with their 6-4 record overall, but their 3-4 conference record has them lower in the Big 12. They haven't been a great road team this year either with their 2-3 road record. They had a really nice start to the season, but lately they have been falling apart and are off another loss in their last one, losing to BYU 44-13. They had a great offense to start the season too, but now they haven't been putting up as many points lately and it hasn't helped that their defense has been giving up a ton of points all year. Houston is off a 30-27 win over UCF in their last one and their offense has been rolling lately. They also have a really good defense that hasn't been giving up a ton of points for most of the season and that is going to give them the edge in this game with the home advantage too. Look for Houston to bring their best effort at home against a stumbling TCU team. The best way to place a bet here is on Houston to cover the spread in this game. 

TCU Houston Prediction:  Our NCAAF Pick for Saturday, November 22, 2025 (4:00 pm ET start time) is Houston 27 TCU 24.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this TCU Horned Frogs Houston Cougars prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

TCU Horned Frogs: 4-10 ATS in road lined games. 1-5 ATS as a road underdog. 1-4 ATS on the road off a loss against a conference rival. 8-3 OVER when the line is +3 to -3. 3-0 OVER after scoring 14 points or less last game.

Houston Cougars: 5-2 ATS when the line is +3 to -3. 30-20 ATS at home off a road win. 50-35 ATS at home after 1 or more consecutive straight up wins. 8-4 OVER as a favorite. 

TCU Horned Frogs:  C. Jamerson (CB) Questionable - Undisclosed. T. Coppinger (DL) Questionable - Undisclosed. C. Sempebwa (K) Questionable - Undisclosed. B. Whatley (DL) Questionable - Undisclosed. E. Small (WR) Questionable - Undisclosed. J. Hayes (WR) Questionable - Undisclosed. L. Lingard (LB) Questionable - Undisclosed. K. Barnes (RB) Questionable - Undisclosed. E. Jackson (CB) Questionable - Undisclosed. L. Kaiuway (TE) Questionable - Undisclosed. J. Jones (OG) Questionable - Undisclosed. K. Lemmermann (K) Questionable - Undisclosed. K. Abrams (LB) Out - Leg.

Houston Cougars:  C. Brathwaite (LB) Questionable - Undisclosed. J. Ridgle (RB) Questionable - Undisclosed. T. Frederick Jr. (TE) Questionable - Undisclosed. K. West (CB) Questionable - Undisclosed. Q. Lee (DL) Questionable - Undisclosed. D. Williams (WR) Questionable - Undisclosed. S. Johnson (WR) Out - Undisclosed. D. Ndukwe (OG) Out - Leg. R. Sanford II (RB) Out - Undisclosed.

“Our guys were excited to play, I can promise you. We just didn’t get off to a great start, BYU took the ball down and scored quickly on us and made us get on our heels pretty quickly.” - Sonny Dykes after his team’s loss against BYU in their last game. 

"I think it was really good for us. We had a team meeting on Monday, and I told them our No. 1 goal was to get as healthy as we possibly can. So we were very careful with probably five or six guys who were banged up. We've been getting them through the last two to three games. Now it looks like all of those guys are really healthy." - Willie Fritz on his team having a late bye week.

WR Dwyer, Jordan

WR McAlister, Eric

WR Manjack IV, Joseph

TE Rogers, DJ

QB Hoover, Josh

RB Barnes, Kevorian

WR Young, Koby

WR Broussard III, Harvey

WR Thomas, Amare

TE Koziol, Tanner

QB Weigman, Conner

RB Connors, Dean

Passing: Josh Hoover (2,873)

Rushing: Kevorian Barnes (443)

Receiving: Eric McAlister (941)

Touchdowns: Eric McAlister (8)

Passing: Conner Weigman (2,113)

Rushing: Dean Connors (725)

Receiving: Amare Thomas (737)

Touchdowns: Conner Weigman (9)

Coaches:

TCU Horned Frogs: Sonny Dykes (4th season)

Houston Cougars: Willie Fritz (2nd season)