Tampa Bay Rays vs Baltimore Orioles Prediction, Preview and Odds - 08/22/2026

Game Time: 7:05 pm ET, Saturday, August 22, 2026

Venue:  Oriole Park at Camden Yards, Baltimore, MD

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Rays -131, Orioles +109; Over/Under:  8 runs

Bet365:  Moneyline odds:  Rays -130, Orioles +110; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Rays -130, Orioles +110; Over/Under:  8 runs

Tampa Bay Rays:  76-51 (1st place, AL East)

Baltimore Orioles:  61-67 (5th place, AL East)

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Tampa Bay Rays:  5-5 last 10

Baltimore Orioles:  4-6 last 10

The Rays are entering this series off a loss and lost their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 76-51 record overall and have a road record of 33-28. This is the 2nd game of a 3-game series with the Orioles on Saturday with the series opener still to be played on Friday. Their offense ranks 6th in the MLB with a .737 OPS. Freddy Peralta is their starting pitcher on Friday while Shane McClanahan is making his start in this game on Saturday. He is 9-6 with a 3.25 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 1 HR, and 0 BB with 3 SO on 4 hits through 3.1 IP against the Baltimore Orioles.

The Orioles are entering this series off a loss and got swept in their 3-game series against the New York Yankees 3-0 in their last series. They enter this game with a 61-67 record overall and have a home record of 32-33. This is the 2nd game of a 3-game series with the Rays on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 17th in the MLB with a .715 OPS. Trevor Rogers is their starting pitcher on Friday while Brandon Young is making his start in this game on Saturday. He is 9-3 with a 3.52 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 3 homers, and 1 walk with 3 strikeouts on 8 hits through 4 innings pitched against the Tampa Bay Rays.

The current betting odds have the Rays listed as a slight favorite in this game according to Draftkings Sportsbook. The Orioles haven't looked good in their games this season with their 61-67 record overall which has them right at the bottom of the AL East. They haven't looked great in their own ballpark either with their 32-33 home record this season. Meanwhile, the Rays have looked great in their games this season with their 76-51 record overall which has them right at the top of the AL East with one of the best records in MLB. They have been a good road team too with their 33-28 road record this year. The Rays are 5-5 in their last 10 games now and have cooled off from their hot streak winning 9 games in a row, but the Orioles are also 4-6 in their last 10 games and haven't looked any better lately, getting swept by the Yankees in their last series. The Rays will be going with McClanahan in this one and he has looked good this season. He is 9-6 with a 3.25 ERA and the team has been having a lot of success with him lately. They have won 3 games in a row now with him starting and even though he gave up 3 earned runs in his last start, that hasn't been a common theme for him. The Orioles are going with Young in this one and he has looked good this season too. He is 9-3 with a 3.52 ERA and hasn't been giving up many runs, but lately the team has been having trouble with him. They have lost 2 of their last 3 games with him starting and he is starting to falter now, coming off a bad start in which he gave up 4 earned runs. The Orioles don't have a bad offense, but they don't have a great one either. The Rays have a top offense in the league right now along with the much stronger bullpen to lean on here, and they will be looking to get revenge after losing 3 of their 4 games at home against the Orioles last weekend. The best way to place a bet here is on the Rays to win this game. 

Rays Orioles Prediction:  Our MLB Pick for Saturday, August 22, 2026 (7:05 pm ET start time) is Rays 4 Orioles 1.

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Tampa Bay Rays: 123-87 (+18.1 units) on the moneyline when the money line is -100 to -150. 121-90 (+9.3 units) on the moneyline when playing against a team with a losing record. 121-101 (+2.2 units) on the moneyline vs. an AL team with a slugging percentage of .410 or worse on the season. 30-17 UNDER when the total is 8 to 8.5.

Baltimore Orioles: 227-227 (-23.5 units) on the moneyline in all games. 115-113 (-30.9 units) on the moneyline in home games. 62-68 (-7.7 units) on the moneyline against left-handed starters. 30-15 UNDER as a home underdog of +100 or higher.

Tampa Bay Rays:  V. Mesa Jr. (RF) Ten Day IL - Hamstring. G. Jax (SP) Fifteen Day IL - Elbow. B. Williamson (2B) Ten Day IL - Hamstring. J. Fraley (RF) Sixty Day IL - Groin. C. Sulser (RP) Fifteen Day IL - Back. J. Heasley (RP) Sixty Day IL - Elbow. G. Lux (LF) Sixty Day IL - Shoulder. R. Pepiot (SP) Sixty Day IL - Hip. E. Uceta (RP) Sixty Day IL - Shoulder. M. Rodriguez (RP) Sixty Day IL - Elbow.

Baltimore Orioles:  R. Mountcastle (1B) Sixty Day IL - Foot. B. Alexander (3B) Ten Day IL - Hand. K. Akin (RP) Sixty Day IL - Elbow. R. Helsley (RP) Sixty Day IL - Elbow. Z. Eflin (SP) Sixty Day IL - Elbow. J. Westburg (3B) Sixty Day IL - UCL. F. Bautista (RP) Sixty Day IL - Shoulder. C. Selby (SP) Sixty Day IL - Shoulder.

“Maybe it’s a good thing to get back out on the road.” - Kevin Cash after his team’s loss against the Blue Jays in their game on Thursday.  

"I was extremely impressed with him, just his demeanor, especially for a young player navigating his first big league camp. He had a great mound presence about him, pounded the strike zone. He has elite stuff. A little funky arm angle, too. It's one of those things where it's keeping our options open for us. But he's an exciting young arm with a lot of talent, and a great kid." - Craig Albernaz on their prospect Luis De Leon.

Chandler Simpson (L) LF

Junior Caminero (R) 3B

Jonathan Aranda (L) 1B

Yandy Díaz (R) DH

Cedric Mullins (L) CF

Jonny DeLuca (R) RF

Richie Palacios (L) 2B

Jorge Mateo (R) SS

Nick Fortes (R) C

Jackson Holliday (L) 2B

Pete Alonso (R) 1B

Gunnar Henderson (L) SS

Samuel Basallo (L) DH

Christian Encarnacion-Strand (R) 3B

Dylan Beavers (L) LF

Leody Taveras (S) RF

Colton Cowser (L) CF

Carlos Narváez (R) C

Batting Average:  Chandler Simpson (.309)

Hits:  Yandy Díaz (148)

Home Runs:  Junior Caminero (35)

RBI:  Junior Caminero (81)

Stolen Bases:  Chandler Simpson (35)

Wins:  Drew Rasmussen (13)

Saves:  Bryan Baker (36)

ERA:  Bryan Baker (1.44)

Batting Average:  Blaze Alexander (.312)

Hits:  Pete Alonso (129)

Home Runs:  Pete Alonso (29)

RBI:  Pete Alonso (82)

Stolen Bases:  Leody Taveras (10)

Wins:  Brandon Young (9)

Saves:  Ryan Helsley (8)

ERA:  Jose Espada (0.00)

Managers:

Tampa Bay Rays: Kevin Cash (12th season)

Baltimore Orioles: Craig Albernaz (1st season)