Tampa Bay Buccaneers vs Seattle Seahawks Prediction, Preview and Odds - 10/05/2025

Game Time: 4:05 pm ET, Sunday, October 5, 2025

Venue:  Lumen Field, Seattle, WA

Where to Watch:  CBS

DraftKings:  Point Spread:  Buccaneers +3.5, Seahawks -3.5; Over/Under:  44.5 points

Bet365:  Point Spread:  Buccaneers +3.5, Seahawks -3.5; Over/Under:  44.5 points

BetMGM:  Point Spread:  Buccaneers +3.5, Seahawks -3.5; Over/Under:  44.5 points

Tampa Bay Buccaneers:  3-1 (1st place, NFC South)

Seattle Seahawks:  3-1 (2nd place, NFC West)

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Tampa Bay Buccaneers:  lost their last game at home against the Philadelphia Eagles 31-25.

Seattle Seahawks:  won their last game on the road against the Arizona Cardinals 23-20.

The Buccaneers are entering this game with a 3-1 record overall and they have a 1-0 record in their divisional games too. They are 1-1 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Philadelphia Eagles 31-25. Baker Mayfield was the starting QB and he completed 22/40 passes for 289 passing yards, 2 touchdowns, and 1 interception. Bucky Irving led the team in rushing yards with 63. Bucky Irving led the receivers with 102 receiving yards on 5 receptions and 1 TD. SirVocea Dennis led the defense in that game with 6 solo tackles and 2 assisted tackles while Vita Vea led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

 

 

 

The Seahawks are entering this game with a 3-1 record overall and they have a 1-1 record in their divisional games too. They are 1-1 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Arizona Cardinals 23-20. Sam Darnold was the starting QB and he completed 18/26 passes for 242 passing yards, 1 touchdown, and 0 interceptions. Kenneth Walker III led the team in rushing yards with 81. Jaxon Smith-Njigba led the receivers with 79 receiving yards on 4 receptions. Julian Love led the defense in that game with 6 solo tackles and 0 assisted tackles while Uchenna Nwosu led the defense in sacks with 2. Ernest Jones IV and Coby Bryant each came away with 1 interception for them in that one.

The current betting odds have the Seahawks listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The Seahawks have looked really good in their games this season with their 3-1 record overall which has them in the running for the NFC West early on. They have one of the best defenses in the NFL this season and the offense has been getting better as Darnold settles in. They lost their season opener, but now they have won 3 games in a row and have a ton of momentum on their side. They are also off a road win over the Cardinals in their last one which was an important division game for them to win, and they played that game on Thursday so they have had extra time to get ready for this game. Meanwhile, the Buccaneers have looked really good in their games this season with their 3-1 record overall which has them right at the top of the NFC South. They are off their first loss of the season against the Eagles and they didn't look good in that one. They made that game a lot closer in the end, but they are dealing with a lot of injuries to key players right now and that was very apparent against the Eagles. This is a tough game for the banged up Bucs to go across the country and win on the West Coast, especially against that Seahawks defense that has been one of the best in the NFL this season. The best way to place a bet here is on the Seahawks to cover the spread in this game. 

Buccaneers Seahawks Prediction:  Our NFL Pick for Sunday, October 5, 2025 (4:05 pm ET start time) is Seahawks 27 Buccaneers 20.

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Tampa Bay Buccaneers: 12-3 ATS as a road underdog. 8-0 ATS after a loss by 6 or less points. 4-0 ATS vs. good defensive teams who give up 17 or less points/game. 7-4 OVER as a road underdog of 7 points or less. 7-4 OVER in a road game where the total is between 42.5 and 49 points.

Seattle Seahawks: 6-13 ATS in home games. 4-8 ATS as a favorite of 3.5 to 9.5 points. 4-10 ATS in a home game where the total is between 42.5 and 49 points. 7-2 OVER as a home favorite of 7 points or less. 

Tampa Bay Buccaneers:  C. Heck (OT) Injured - Knee. Z. McCollum (CB) Injured - Thumb. J. Dean (CB) Injured - Hip. M. Evans (WR) Injured - Hamstring. G. Gaines (DL) Injured - Pectoral. B. Irving (RB) Injured - Foot. C. Izien (S) Injured - Quad. B. Mayfield (QB) Injured - Knee. B. Morrison (CB) Injured - Hamstring. S. Shepard (WR) Injured - Foot. T. Smith (S) Injured - Ankle. L. David (LB) Injured - Knee. L. Hall (DL) Injured - Groin. H. Reddick (LB) Injured - Neck. T. Wirfs (OT) Injured - Knee. C. Godwin Jr. (WR) Injured - Ankle.

Seattle Seahawks:  J. Jones (OG) Injured - Ankle. D. Lawrence (DL) Injured - Quad. J. Love (S) Injured - Hamstring. D. Witherspoon (CB) Injured - Knee. N. Emmanwori (S) Injured - Ankle. C. White (WR) Injured - Shoulder.

“Obviously, he’s got to take better care of the ball. Baker will be the first one to tell you that." - Todd Bowles after his team’s loss against the Eagles in their last game. 

“I've seen this guy play golf — he's a stud. He's got ice in his veins. We knew he was going to make that kick.” - Mike Macdonald after his team’s win against the Cardinals in their last game. 

WR Miller, Ryan

WR Egbuka, Emeka

WR Godwin Jr., Chris

TE Otton, Cade

QB Mayfield, Baker

RB White, Rachaad

WR Horton, Tory

WR Smith-Njigba, Jaxon

WR Kupp, Cooper

TE Barner, AJ 

QB Darnold, Sam

RB Walker III, Kenneth

FB Russell, Brady

Passing: Baker Mayfield (904)

Rushing: Bucky Irving (237)

Receiving: Emeka Egbuka (282)

Touchdowns: Emeka Egbuka (4)

Passing: Sam Darnold (905)

Rushing: Kenneth Walker III (244)

Receiving: Jaxon Smith-Njigba (402)

Touchdowns: Kenneth Walker III (3)

Coaches:

Tampa Bay Buccaneers: Todd Bowles (4th season)

Seattle Seahawks: Mike Macdonald (2nd season)