Tampa Bay Buccaneers vs Houston Texans Prediction, Preview and Odds - 09/15/2025

Game Time: 7:00 pm ET, Monday, September 15, 2025

Venue:  NRG Stadium, Houston, TX 

Where to Watch:  ABC, ESPN

DraftKings:  Point Spread:  Buccaneers +2.5, Texans -2.5; Over/Under:  42.5 points

Bet365:  Point Spread:  Buccaneers +2.5, Texans -2.5; Over/Under:  42.5 points

BetMGM:  Point Spread:  Buccaneers +2.5, Texans -2.5; Over/Under:  42.5 points

Tampa Bay Buccaneers:  1-0 (1st place, NFC South)

Houston Texans:  0-1 (4th place, AFC South)

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Tampa Bay Buccaneers:  won their last game on the road against the Atlanta Falcons 23-20.

Houston Texans:  lost their last game on the road against the Los Angeles Rams 14-9.

The Buccaneers are entering this game with a 1-0 record overall and they have a 1-0 record in their divisional games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Atlanta Falcons 23-20. Baker Mayfield was the starting QB and he completed 17/32 passes for 167 passing yards, 3 touchdowns, and 0 interceptions. Baker Mayfield led the team in rushing yards with 39. Emeka Egbuka led the receivers with 67 receiving yards on 4 receptions and 2 TDs. Tykee Smith led the defense in that game with 7 solo tackles and 4 assisted tackles while Haason Reddick led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Texans are entering this game with a 0-1 record overall and they have a 0-0 record in their divisional games too. They are 0-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Los Angeles Rams 14-9. C. J. Stroud was the starting QB and he completed 19/27 passes for 188 passing yards, 0 touchdowns, and 1 interception. Nick Chubb led the team in rushing yards with 60. Jayden Higgins led the receivers with 32 receiving yards on 2 receptions. Kamari Lassiter led the defense in that game with 5 solo tackles and 4 assisted tackles while Will Anderson Jr., Henry To'oTo'o, and Folorunso Fatukasi each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have the Buccaneers listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. The Buccaneers have a 1-0 record overall this season and they looked good in their season opener. They beat the Falcons on the road 23-20 in a big divisional game that could have implications later in the season so that win is going to give them some momentum now. They started slow in that one, falling behind early, but they got going in the 2nd half and made the plays needed to win the game. The offense wasn't at it's best, but it is going to look better in week 2 here, and the defense looked a lot better than it was last season too. Meanwhile, the Texans have a 0-1 record overall this season and they didn't look great in their season opener. They lost on the road against the Rams 14-9 and their offense looked terrible in that one. They took a big step back last season as a team after that great 1st year that Ryans and Stroud had, but they still have a lot of problems on both sides of the ball and haven't fixed much from last season. The defense looked great and really kept them in that game, but the offense made critical mistakes which cost them the game. They will likely play better at home in this one, but the Bucs are also going to play better in week 2 as that offense didn't really get going last week, and the Buccaneers are just the better team right now. The best way to place a bet here is on the Buccaneers to cover the spread in this game. 

Buccaneers Texans Prediction:  Our NFL Pick for Monday, September 15, 2025 (7:00 pm ET start time) is Buccaneers 24 Texans 20.

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Tampa Bay Buccaneers: 23-15 ATS in all games. 11-3 ATS as a road underdog. 7-3 ATS after playing a division game. 6-3 UNDER in the first month of the season. 

Houston Texans: 6-10 ATS when playing on Monday night. 2-5 ATS on the road off a road loss. 1-6 ATS in September games. 19-5 UNDER in all games where the total is between 42.5 and 49 points.

Tampa Bay Buccaneers:  G. Gaines (DL) Injured - Ankle. C. Godwin Jr. (WR) Injured - Foot. L. Goedeke (OT) Injured - Foot. C. Izien (S) Injured - Oblique. K. Kieft (TE) Injured - Head. Z. McCollum (CB) Injured - Neck. B. Morrison (CB) Injured - Quad. H. Reddick (LB) Injured - Foot. T. Wirfs (OT) Injured - Knee.

Houston Texans:  C. Kirk (WR) Injured - Hamstring. B. Berrios (WR) Injured - Hamstring. B. Fisher (OT) Injured - Ankle. J. Andrews (C) Injured - Ankle. E. Ingram (OG) Injured - Abdomen.

“He's everything we thought since he's been here. He played with so much poise and Baker (Mayfield) played with so much poise.” - Todd Bowles after his team’s win against the Falcons in their last game. 

“We were making progress, we were making plays, and the one thing that we talked about ... was protecting the football. They took the ball away two times, and took it at the most critical time there as we were driving down to score. Credit to the Rams. They showed up.” - DeMeco Ryans after his team’s loss against the LA Rams in their last game. 

WR Evans, Mike

WR Egbuka, Emeka

WR Godwin Jr., Chris

TE Otton, Cade

QB Mayfield, Baker

RB Irving, Bucky 

WR Collins, Nico

WR Higgins, Jayden

WR Kirk, Christian

TE Schultz, Dalton

QB Stroud, C.J.

RB Chubb, Nick

FB Brooks, British

Passing: B. Mayfield (167)

Rushing: B. Mayfield (39)

Receiving: E. Egbuka (67)

Touchdowns: E. Egbuka (2)

Passing: C. Stroud (188)

Rushing: N. Chubb (60)

Receiving: J. Higgins (32)

Touchdowns: N/A

Coaches:

Tampa Bay Buccaneers: Todd Bowles (4th season)

Houston Texans: DeMeco Ryans (3rd season)