by Rod Pearson
Monday, Nov 17, 2025
Game Time: 3:30 pm ET, Saturday, November 22, 2025
Venue: Notre Dame Stadium, Notre Dame, IN
Where to Watch: NBC, Peacock
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Syracuse +34.5, Notre Dame -34.5; Over/Under: 51.5 points
Bet365: Point Spread: Syracuse +35, Notre Dame -35; Over/Under: 51.5 points
BetMGM: Point Spread: Syracuse +35.5, Notre Dame -35.5; Over/Under: 51.5 points
Season Record
Syracuse Orange: 3-7 (1-6) (16th place, ACC)
Notre Dame Fighting Irish: 8-2 (0-0) (FBS Independent)
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Syracuse Orange: lost their last game on the road against the Miami Hurricanes 38-10.
Notre Dame Fighting Irish: won their last game on the road against the Pittsburgh Panthers 37-15.
Syracuse Orange vs Notre Dame Fighting Irish Preview and Analysis
Syracuse is entering this game with a 3-7 record overall and they have a 1-6 record in their conference games too. They are 2-3 in their home games, 1-3 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Miami-FL 38-10. Rickie Collins was the starting QB and he completed 12/25 passes for 85 passing yards, 0 touchdowns, and 2 interceptions. Yasin Willis led the team in rushing yards with 63. Daunte Bacheyie led the receivers with 22 receiving yards on 2 receptions. Demetres Samuel Jr. led the defense in that game with 5 solo tackles and 0 assisted tackles while Gary Bryant III and A'Varius Sparrow each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Notre Dame is entering this game with an 8-2 record overall and they have a 0-0 record in their conference games too. They are 5-1 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Pittsburgh 37-15. CJ Carr was the starting QB and he completed 21/32 passes for 212 passing yards, 2 touchdowns, and 2 interceptions. Jeremiyah Love led the team in rushing yards with 147 and 1 TD. Malachi Fields led the receivers with 99 receiving yards on 7 receptions and 2 TDs. Jaylen Sneed led the defense in that game with 3 solo tackles and 3 assisted tackles while Joshua Burnham led the defense in sacks with 2. Tae Johnson came away with the only interception for them in that one.
Syracuse vs Notre Dame Prediction
The current betting odds have Notre Dame listed as a 34.5 point favorite in this game according to Draftkings Sportsbook. Notre Dame has looked great in their games this season with their 8-2 record overall which has them ranked inside the top 10 at the moment and going to the CFP. They started the season 0-2 with losses to Miami and Texas A&M, but they have won 8 games in a row now and have a ton of momentum on their side. Meanwhile, Syracuse has looked terrible in their games this season with their 3-7 record overall and their 1-6 conference record which has them right near the bottom of the ACC. They had a promising start to the season and even pulled off an upset win over Clemson, but they lost their starting QB for the season in that win and their season went down the drain with him. They have been getting blown out in a lot of games with their offense looking terrible, struggling to put up points with their backup QB, and they didn't have a great defense to start with either. Notre Dame is off a 37-15 win over Pittsburgh in their last one and their defense has looked better and better as the season has gone on. Syracuse won't be able to do much on offense, and that defense isn't going to stop this Notre Dame offense that has been rolling lately. The best way to place a bet here is on Notre Dame to cover the spread in this game.
Syracuse Notre Dame Prediction: Our NCAAF Pick for Saturday, November 22, 2025 (3:30 pm ET start time) is Notre Dame 56 Syracuse 10.
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NCAAF Betting Trends
Syracuse Orange: 5-9 ATS when the total is between 49.5 and 56. 0-6 ATS after a bye week. 4-8 ATS after playing their last game on the road. 4-9 ATS vs. good offensive teams - scoring 31 or more points/game. 8-4 OVER as a road underdog.
Notre Dame Fighting Irish: 25-11 ATS in all lined games. 23-10 ATS as a favorite. 9-4 ATS against ACC opponents. 13-5 ATS after a win by 17 or more points. 5-1 ATS when playing against a team with a losing record. 5-1 OVER when playing against a team with a losing record. 21-14 OVER as a favorite.
Key Injuries
Syracuse Orange: A. Boeheim (OG) Questionable - Undisclosed. E. Ross (WR) Questionable - Undisclosed. J. Miller (OG) Questionable - Undisclosed. T. Ferguson (OG) Questionable - Undisclosed. C. Simmons (TE) Questionable - Undisclosed. F. Brown Jr. (LS) Questionable - Undisclosed. R. Perry (DL) Questionable - Undisclosed. J. Iak (OG) Questionable - Undisclosed. M. James (RB) Questionable - Undisclosed. N. Prater (CB) Questionable - Undisclosed. D. McDonald (LB) Questionable - Undisclosed. S. Angeli (QB) Out - Achilles. T. Russell (WR) Out - Undisclosed. J. McFadden (WR) Out - Collarbone. M. Petry (OG) Out - Knee.
Notre Dame Fighting Irish: S. Sevillano Jr. (DL) Questionable - Ankle. P. Jones (OG) Questionable - Ankle. C. Jagusah (OG) Questionable - Arm. G. Rubio (DL) Questionable - Elbow. N. Burnette (K) Questionable - Undisclosed. C. Flanagan (TE) Questionable - Achilles. J. Greathouse (WR) Questionable - Thigh. B. Schrauth (OG) Out - Knee. A. Craig (OG) Out - Knee. K. Young (RB) Out - Knee. B. Logan (S) Out - Shoulder. D. Devezin (RB) Out - Shoulder.
Notable Quotes
“We had lot of self-inflicted wounds. I think they’re a really good football team.” - Fran Brown after his team’s loss against Miami-Florida in their last game.
"Yeah, man, obviously a satisfying win over a really good opponent. I was proud of the way our guys prepared to handle the excitement around this game and the hype and College GameDay being here. They handled it the right way by using their energy to work and they prepared the right way and went out and started from the beginning, started fast and it wasn't perfect, but it's never perfect against a good opponent and so we're going to celebrate it tonight, enjoy this and then we'll get ready for this next opportunity tomorrow for Senior Day back at home. So with that, I'll open up for questions." - Marcus Freeman after his team’s win against Pitt in their last game.
Starting Lineups
Syracuse Orange
WR Ross-Simmons, Justus
WR Gill Jr., Darrell
WR Cook, Johntay
TE Villari, Dan
QB Collins, Rickie
RB Willis, Yasin
Notre Dame Fighting Irish
WR Fields, Malachi
WR Faison, Jordan
WR Greathouse, Jaden
TE Raridon, Eli
QB Carr, CJ
RB Love, Jeremiyah
Statistical Leaders
Syracuse Orange
Passing: Steve Angeli (1,317)
Rushing: Yasin Willis (558)
Receiving: Johntay Cook (518)
Touchdowns: Justus Ross-Simmons (5)
Notre Dame Fighting Irish
Passing: CJ Carr (2,487)
Rushing: Jeremiyah Love (1,135)
Receiving: Malachi Fields (596)
Touchdowns: Jeremiyah Love (17)
Coaches:
Syracuse Orange: Fran Brown (2nd season)
Notre Dame Fighting Irish: Marcus Freeman (5th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
