St Louis Cardinals vs New York Yankees Prediction, Preview and Odds - 08/05/2026

Game Time: 7:05 pm ET, Wednesday, August 5, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV, Prime Video

DraftKings:  Moneyline odds:  Cardinals +123, Yankees -149; Over/Under:  9 runs

Bet365:  Moneyline odds:  Cardinals +125, Yankees -150; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Cardinals +125, Yankees -150; Over/Under:  9 runs

St Louis Cardinals:  56-57 (4th place, NL Central)

New York Yankees:  63-50 (2nd place, AL East)

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St Louis Cardinals:  4-6 last 10

New York Yankees:  5-5 last 10

The Cardinals are entering this series off a win and lost their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 56-57 record overall and have a road record of 28-25. This is the series finale of a 3-game series with the Yankees on Wednesday with the 2nd game still to be played on Tuesday. The Cardinals won the series opener on Monday. Their offense ranks 24th in the MLB with a .695 OPS. Hunter Dobbins is their starting pitcher on Tuesday while Andre Pallante is making his start in this game on Wednesday. He is 11-6 with a 3.72 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 2 BB with 3 SO on 7 hits through 6.1 IP against the Chicago Cubs.

The Yankees are entering this series off a win and won their 3-game series against the Chicago Cubs 2-1 in their last series. They enter this game with a 63-50 record overall and have a home record of 26-24. This is the 3rd game of a 3-game series with the Cardinals on Wednesday with the 2nd game of this series still to be played on Tuesday. The Yankees lost the 1st game of this series on Monday. Their offense ranks 13th in the MLB with a .724 OPS. Ryan Weathers is their starting pitcher on Tuesday while Will Warren is making his start in this game on Wednesday. He is 8-5 with a 4.14 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 0 walks with 7 strikeouts on 4 hits through 6.2 innings pitched against the Chicago Cubs.

The current betting odds have the Cardinals listed as an underdog in this game according to Draftkings Sportsbook. The Yankees have looked good in their games this season with their 63-50 record overall which has them right near the top of the AL East. They have looked good in their own ballpark too with their 26-24 home record this season. Meanwhile, the Cardinals haven't looked great in their games this season with their 56-57 record overall which has them right near the bottom of the NL Central. They have been a good road team though with their 28-25 road record this year. The Yankees haven't been at their best lately, now 5-5 in their last 10 games, and their offense has been having a lot of trouble lately as they deal with injuries. The Cardinals are 4-6 in their last 10 games and haven't looked great lately themselves, but they did take the 1st game of this series on Monday and they are going to have the better pitching matchup in this one. The Cardinals are going with Pallante in this one and he has looked great this season. He is 11-6 with a 3.72 ERA and he leads the team in wins this year. The team has had more trouble with him lately, losing 3 of their last 4 games now with him starting, but he only gave up 2 earned runs in his last start and that has been a common theme for him all season. The Yankees are going with Warren in this one and he hasn't looked great this season. He is 8-5 with a 4.14 ERA and he has looked a lot better lately, but he has been giving up a lot of runs all year. He is coming off a great start in which he gave up no runs and the team has won 3 of their last 4 games with him starting too, but that hasn't been a common theme for him this season. The Cardinals are desperate to break out of their funk after being a solid team in the NL all year and this is a pitching matchup that they can definitely take advantage of with the Yankees offense slipping over the last few weeks. The best way to place a bet here is on the Cardinals to win this game. 

Cardinals Yankees Prediction:  Our MLB Pick for Wednesday, August 5, 2026 (7:05 pm ET start time) is Cardinals 5 Yankees 3.

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St Louis Cardinals: 115-121 (+23.9 units) on the moneyline as an underdog of +100 or higher. 57-52 (+17.6 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 70-70 (+15.1 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 20-10 UNDER when playing against a good team (Win Pct. 54% to 62%).

New York Yankees: 21-22 (-12.5 units) on the moneyline against NL Central opponents. 261-196 (-19.2 units) on the moneyline in all games. 127-97 (-30.1 units) on the moneyline in home games. 9-4 UNDER against NL Central opponents.

St Louis Cardinals:  M. Rajcic (SP) Sixty Day IL - Elbow. R. Urias (3B) Sixty Day IL - Elbow.

New York Yankees:  C. Bellinger (LF) Ten Day IL - Leg. A. Judge (RF) Sixty Day IL - Rib. C. Rodon (SP) Fifteen Day IL - Elbow. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

“I can’t credit that group enough for the response today. There was a lot going on today. It’s kind of easy to be down on the fact that you lose a couple of guys. It’s felt in that clubhouse. It just shows you the mentality of the group. They are not going to give up, give out or give in. They didn’t concede to anything. That response in this environment against [Schlittler] on the Trade Deadline day was pretty impressive.” - Oliver Marmol after his team’s win against the Yankees in their game on Monday. 

“In a lot of ways, it was good to see us swing the bat like this. I thought we had a lot of good at-bats, obviously highlighted by Luis. Giving us the lead there, it was an awesome way to debut. Hopefully there’s a lot more of that to come.” - Aaron Boone after his team’s loss against the Cardinals in their game on Monday. 

JJ Wetherholt (L) 2B

Jordan Walker (R) RF

Alec Burleson (L) 1B

Iván Herrera (R) DH

Bryan Torres (L) LF

Masyn Winn (R) SS

Nathan Church (L) CF

José Fermín (R) 3B

Jimmy Crooks (L) C

Trent Grisham (L) CF

Ben Rice (L) DH

Luis García Jr. (L) 1B

Spencer Jones (L) LF

Jasson Domínguez (S) RF

Jazz Chisholm Jr. (L) 2B

Ryan McMahon (L) 3B

José Caballero (R) SS

Austin Wells (L) C

Batting Average:  Alec Burleson (.288)

Hits:  Alec Burleson (124)

Home Runs:  Jordan Walker (22)

RBI:  Jordan Walker (81)

Stolen Bases:  Jordan Walker (14)

Wins:  Andre Pallante (11)

Saves:  Riley O'Brien (26)

ERA:  Ryan Fernandez (2.70)

Batting Average:  Luis García (.500)

Hits:  Ben Rice (106)

Home Runs:  Ben Rice (31)

RBI:  Ben Rice (73)

Stolen Bases:  Jazz Chisholm (30)

Wins:  Cam Schlittler (10)

Saves:  David Bednar (24)

ERA:  Yerry De los Santos (1.04)

Managers:

St Louis Cardinals: Oliver Marmol (5th season)

New York Yankees: Aaron Boone (9th season)