St Louis Cardinals vs New York Yankees Prediction, Preview and Odds - 08/04/2026

Game Time: 7:05 pm ET, Tuesday, August 4, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Cardinals +129, Yankees -156; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Cardinals +130, Yankees -155; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Cardinals +130, Yankees -155; Over/Under:  8.5 runs

St Louis Cardinals:  55-57 (4th place, NL Central)

New York Yankees:  63-49 (2nd place, AL East)

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St Louis Cardinals:  3-7 last 10

New York Yankees:  6-4 last 10

The Cardinals are entering this series off a win and lost their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 55-57 record overall and have a road record of 27-25. This is the 2nd game of a 3-game series with the Yankees on Tuesday with the series opener still to be played on Monday. Their offense ranks 26th in the MLB with a .689 OPS. Michael McGreevy is their starting pitcher on Monday while Andre Pallante is making his start in this game on Tuesday. He is 11-6 with a 3.72 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 2 BB with 3 SO on 7 hits through 6.1 IP against the Chicago Cubs.

The Yankees are entering this series off a win and won their 3-game series against the Chicago Cubs 2-1 in their last series. They enter this game with a 63-49 record overall and have a home record of 26-23. This is the 2nd game of a 3-game series with the Cardinals on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 16th in the MLB with a .721 OPS. Cam Schlittler is their starting pitcher on Monday while Ryan Weathers is making his start in this game on Tuesday. He is 4-7 with a 3.99 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 3 walks with 4 strikeouts on 3 hits through 7 innings pitched against the Chicago White Sox.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked good in their games this season with their 63-49 record overall which has them right near the top of the AL East. They have looked good in their own ballpark too with their 26-23 home record this season. Meanwhile, the Cardinals haven't looked great in their games this season with their 55-57 record overall which has them right near the bottom of the NL Central. They have been a good road team though with their 27-25 road record this year. The Cardinals had a really hot start to the season, but now they are 3-7 in their last 10 games and they have been falling apart lately. They have played themselves into a position where they might need to sell now and they aren't going to have the best option starting in this game. They have one of the worst offenses in the league too and that is going to be an issue here since the Yankees have a great offense. The Yankees are coming off a series win over the Cubs in their last series and they are starting to get hot again, now 6-4 in their last 10 games. They are going with Weathers in this one and he has looked good this season. He is 4-7 with a 3.99 ERA and he has looked a lot better lately. He is coming off another great start in which he gave up no runs, something that has been becoming a common theme for him lately, and the team has won 3 of their last 4 games with him starting too. The Cardinals are in a bad position here with the trade deadline while the Yankees have been getting hot and can take advantage of this pitching matchup with the better offense. The best way to place a bet here is on the Yankees to win this game. 

Cardinals Yankees Prediction:  Our MLB Pick for Tuesday, August 4, 2026 (7:05 pm ET start time) is Yankees 7 Cardinals 3.

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St Louis Cardinals: 67-56 (+11.7 units) on the moneyline against left-handed starters. 56-52 (+15.5 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 69-70 (+13 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 20-12 UNDER vs. teams outscoring opp by 0.5 or more runs/game on the season.

New York Yankees: 21-21 (-10.1 units) on the moneyline against NL Central opponents. 261-195 (-16.9 units) on the moneyline in all games. 127-96 (-27.8 units) on the moneyline in home games. 9-3 UNDER against NL Central opponents.

St Louis Cardinals:  J. Romero (RP) Fifteen Day IL - Appendix. M. Rajcic (SP) Sixty Day IL - Elbow. R. Urias (3B) Sixty Day IL - Elbow.

New York Yankees:  C. Bellinger (LF) Ten Day IL - Leg. A. Judge (RF) Sixty Day IL - Rib. C. Rodon (SP) Fifteen Day IL - Elbow. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

“That's what good teams learn to do. Once there's a tight game, [they] make a mistake, you’ve got to be able to cash in.” - Oliver Marmol after his team’s win against the Blue Jays in their game on Sunday. 

“He rakes.” - Aaron Boone on acquiring Luis Garcia Jr. after his team’s win against the Cubs in their game on Sunday.  

Lars Nootbaar (L) RF

Jordan Walker (R) DH

Alec Burleson (L) 1B

Iván Herrera (R) C

Masyn Winn (R) SS

Bryan Torres (L) LF

José Fermín (R) 2B

Nathan Church (L) CF

Blaze Jordan (R) 3B

Trent Grisham (L) CF

Ben Rice (L) 1B

Amed Rosario (R) DH

Spencer Jones (L) LF

Jasson Domínguez (S) RF

Jazz Chisholm Jr. (L) 2B

Ryan McMahon (L) 3B

José Caballero (R) SS

Austin Wells (L) C

Batting Average:  Alec Burleson (.284)

Hits:  Alec Burleson (121)

Home Runs:  Jordan Walker (22)

RBI:  Jordan Walker (81)

Stolen Bases:  Jordan Walker (14)

Wins:  Andre Pallante (11)

Saves:  Riley O'Brien (26)

ERA:  Ryan Fernandez (2.70)

Batting Average:  Ali Sánchez (.273)

Hits:  Ben Rice (106)

Home Runs:  Ben Rice (31)

RBI:  Ben Rice (73)

Stolen Bases:  Jazz Chisholm (30)

Wins:  Cam Schlittler (10)

Saves:  David Bednar (24)

ERA:  Angel Chivilli (0.57)

Managers:

St Louis Cardinals: Oliver Marmol (5th season)

New York Yankees: Aaron Boone (9th season)