St Louis Cardinals vs Milwaukee Brewers Prediction, Preview and Odds - 05/26/2026

Game Time: 7:40 pm ET, Tuesday, May 26, 2026

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Cardinals +135, Brewers -163; Over/Under:  8 runs

Bet365:  Moneyline odds:  Cardinals +135, Brewers -165; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Cardinals +135, Brewers -165; Over/Under:  8 runs

St Louis Cardinals:  29-22 (2nd place, NL Central)

Milwaukee Brewers:  30-20 (1st place, NL Central)

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St Louis Cardinals:  5-5 last 10

Milwaukee Brewers:  7-3 last 10

The Cardinals are entering this series off a loss and split their 2-game series against the Cincinnati Reds 1-1 in their last series. They enter this game with a 29-22 record overall and have a road record of 16-9. This is the 2nd game of a 3-game series with the Brewers on Tuesday with the series opener still to be played on Monday. Their offense ranks 13th in the MLB with a .712 OPS. Matthew Liberatore is their starting pitcher on Monday while Michael McGreevy is making his start in this game on Tuesday. He is 3-3 with a 2.40 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 1 HR, and 1 BB with 1 SO on 10 hits through 5 IP against the Pittsburgh Pirates.

The Brewers are entering this series off a loss and lost their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 30-20 record overall and have a home record of 16-11. This is the 2nd game of a 3-game series with the Cardinals on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 17th in the MLB with a .696 OPS. Jacob Misiorowski is their starting pitcher on Monday while Kyle Harrison is making his start in this game on Tuesday. He is 5-1 with a 1.77 ERA this season. His team won their last 6 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 1 walk with 11 strikeouts on 2 hits through 7 innings pitched against the Chicago Cubs.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 30-20 record overall which has them right at the top of the NL Central. They have looked good in their own ballpark too with their 16-11 home record this season. Meanwhile, the Cardinals have looked good in their games this season with their 29-22 record overall which has them right near the top of the NL Central. They have been a great road team too with their 16-9 road record this year. The Cardinals have had a great start to the season, but lately they haven't looked as good. They are only 5-5 in their last 10 games while the Brewers are 7-3 in their last 10 and have been rolling. The Cardinals are going with McGreevy in this one and he has looked good this season. He is 3-3 with a 2.40 ERA and the team has been having success with him. They have won 3 of their last 4 games with him starting, but he did give up 3 earned runs in his last start and that could be an issue with how good this Brewers pitching staff has been. The Brewers are going with Harrison in this one and he has pretty much been their ace this season. He is 5-1 with a 1.77 ERA and hasn't been giving up many runs at all. He gave up no runs in his last start which has been a common theme for him and the team has won 6 games in a row now with him starting. The Brewers are going to have a big edge with their pitching in this one, especially their bullpen, and their offense has also looked better lately too. The best way to place a bet here is on the Brewers to win this game. 

Cardinals Brewers Prediction:  Our MLB Pick for Tuesday, May 26, 2026 (7:40 pm ET start time) is Brewers 2 Cardinals 1.

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St Louis Cardinals: 102-102 (+25.9 units) on the moneyline as an underdog of +100 or higher. 54-46 (+7.4 units) on the moneyline against left-handed starters. 47-43 (+14.3 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 8-3 UNDER when playing against a good team (Win Pct. 54% to 62%).

Milwaukee Brewers: 36-24 (-8.1 units) on the moneyline as a home favorite of -150 or more. 51-45 (-10 units) on the moneyline vs. NL teams allowing 4.5 or more runs/game on the season. 29-32 (-3.5 units) on the moneyline vs. an NL starting pitcher whose ERA is 3.20 or better. 7-3 UNDER vs. an NL starting pitcher whose WHIP is 1.250 or better.

St Louis Cardinals:  N. Church (LF) Ten Day IL - Lower-body. R. Urias (3B) Ten Day IL - Elbow. L. Nootbaar (LF) Sixty Day IL - Heels.

Milwaukee Brewers:  B. Lockridge (LF) Ten Day IL - Knee. B. Woodruff (SP) Fifteen Day IL - Arm. A. Zerpa (RP) Fifteen Day IL - Forearm. R. Zastryzny (RP) Sixty Day IL - Shoulder. J. Koenig (RP) Fifteen Day IL - Elbow. Q. Priester (SP) Fifteen Day IL - Wrist.

“Eleven years to get to here. I’m not a homer guy. Today, my debut, it just happened. I’ve been learning to manage the pressure. When the heart is going too fast, you have to slow things down. I felt a little pounding in my chest today.” - Bryan Torres on hitting a homer in his MLB debut over the weekend.

“He’s so good when he’s good. In no way, shape or form I think are considering getting him out of there. Conversely…this guy’s got a chance to be a high-end starter.” - Pat Murphy on Sproat after his team’s loss against the LA Dodgers in their game on Sunday. 

JJ Wetherholt (L) 2B

Iván Herrera (R) DH

Alec Burleson (L) 1B

Jordan Walker (R) RF

Nolan Gorman (L) 3B

Masyn Winn (R) SS

Bryan Torres (L) LF

Pedro Pagés (R) C

Victor Scott II (L) CF

Jackson Chourio (R) LF

Brice Turang (L) 2B

William Contreras (R) C

Christian Yelich (L) DH

Andrew Vaughn (R) 1B

Luis Rengifo (S) 3B

Blake Perkins (S) RF

Garrett Mitchell (L) CF

Joey Ortiz (R) SS

Batting Average:  Bryan Torres (.375)

Hits:  Jordan Walker (58)

Home Runs:  Jordan Walker (15)

RBI:  Jordan Walker (42)

Stolen Bases:  Jordan Walker (7)

Wins:  Kyle Leahy (5)

Saves:  Riley O'Brien (13)

ERA:  Ryan Fernandez (1.17)

Batting Average:  Tyler Black (.333)

Hits:  William Contreras (57)

Home Runs:  Jake Bauers (7)

RBI:  William Contreras (30)

Stolen Bases:  David Hamilton (10)

Wins:  Aaron Ashby (8)

Saves:  Trevor Megill (5)

ERA:  Jared Koenig (0.00)

Managers:

St Louis Cardinals: Oliver Marmol (5th season)

Milwaukee Brewers: Pat Murphy (3rd season)