South Florida Bulls vs Memphis Tigers Prediction, Picks and Game Preview - 10/25/2025

Game Time: 12:00 pm ET, Saturday, October 25, 2025

Venue:  Simmons Bank Liberty Stadium, Memphis, TN

Where to Watch:  ESPN2

DraftKings:  Point Spread:  USF -4, Memphis +4; Over/Under:  65.5 points

Bet365:  Point Spread:  USF -4, Memphis +4; Over/Under:  65 points

BetMGM:  Point Spread:  USF -3.5, Memphis +3.5; Over/Under:  65.5 points

South Florida Bulls:  6-1 (3-0) (2nd place, American)

Memphis Tigers:  6-1 (2-1) (5th place, American)

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South Florida Bulls:  won their last game at home against the Florida Atlantic Owls 48-13.

Memphis Tigers:  lost their last game on the road against the UAB Blazers 31-24.

South Florida is entering this game with a 6-1 record overall and they have a 3-0 record in their conference games too. They are 4-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against FAU 48-13. Byrum Brown was the starting QB and he completed 14/24 passes for 256 passing yards, 3 touchdowns, and 0 interceptions. Byrum Brown led the team in rushing yards with 111 and 1 TD. Jeremiah Koger led the receivers with 90 receiving yards on 4 receptions and 1 TD. Mac Harris and James Chenault each led the defense in that game with 7 solo tackles and 2 assisted tackles while Mac Harris led the defense in sacks with 1.5. Rico Watson III came away with the only interception for them in that one.

 

 

 

Memphis is entering this game with a 6-1 record overall and they have a 2-1 record in their conference games too. They are 3-0 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against UAB 31-24. Brendon Lewis was the starting QB and he completed 9/10 passes for 68 passing yards, 0 touchdowns, and 0 interceptions before getting replaced by AJ Hill who completed 13/25 passes for 175 yards, 1 TD, and 1 INT. Greg Desrosiers Jr. led the team in rushing yards with 74 and 1 TD. Cortez Braham Jr. led the receivers with 83 receiving yards on 5 receptions. Drue Watts led the defense in that game with 8 solo tackles and 2 assisted tackles while Sam Brumfield and William Whitlow Jr. each led the defense in sacks with 0.5. Sam Brumfield came away with the only interception for them in that one.

The current betting odds have South Florida listed as a 4 point favorite in this game according to Draftkings Sportsbook. South Florida has looked great in their games this season with their 6-1 record overall which has them right near the top of the American Conference and ranked inside the top 25. Their only loss was against a good Miami team who has been ranked inside the top 5 for most of the season, but they do have a good win over Florida along with some other solid wins they have picked up. They are off a 48-13 win over FAU in their last one and that came right after obliterating North Texas on the road the week before. South Florida has been rolling over opponents since starting their conference schedule and they are making a great case for themselves as the best team in the group of 5. Meanwhile, Memphis has looked good in their games this season with their 6-1 record overall which has them right near the top of the American Conference. They were also ranked inside the top 25, but they just lost that ranking as they are off a 31-24 loss to UAB in their last one. They lost to a terrible UAB team that had just fired their head coach too and that loss has pretty much ended their chances at a playoff spot. Memphis will be looking to bounce back at home, but South Florida has passed almost every test they have had this season and this is another great chance for them to separate themselves at the top of the conference. The best way to place a bet here is on South Florida to cover the spread in this game. 

South Florida Memphis Prediction:  Our NCAAF Pick for Saturday, October 25, 2025 (12:00 pm ET start time) is South Florida 38 Memphis 24.

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South Florida Bulls: 7-2 ATS off a home win. 6-3 ATS after a win by 17 or more points. 10-3 ATS after playing a game at home. 10-2 OVER as a favorite. 11-4 OVER against conference opponents. 5-1 OVER off a home win against a conference rival.

Memphis Tigers: 1-4 ATS vs. poor passing defenses - allowing 250 or more passing yards/game. 17-24 ATS when the total is between 63.5 and 70. 20-12 OVER in all lined games. 5-0 OVER when the total is between 63.5 and 70. 14-5 OVER against conference opponents.

South Florida Bulls:  W. Wolff (TE) Questionable - Undisclosed. M. Williams II (DL) Questionable - Undisclosed. R. Scott III (DL) Questionable - Undisclosed. K. Pettigrew (WR) Questionable - Undisclosed. C. Nimrod (WR) Questionable - Undisclosed. I. Guy (CB) Questionable - Undisclosed. B. Carter (OG) Questionable - Undisclosed. J. Alexis (WR) Questionable - Undisclosed. G. Otten (LB) Out - Undisclosed. B. Silvera (CB) Out - Undisclosed. C. Norton (RB) Out - Undisclosed. S. Franklin (RB) Questionable - Undisclosed.

Memphis Tigers:  B. Lewis (QB) Questionable - Leg. J. Cross (TE) Questionable - Undisclosed. O. Castaneda (K) Questionable - Undisclosed. J. Hunter (CB) Questionable - Undisclosed. C. Miller (CB) Questionable - Undisclosed. C. Law (LB) Out - Undisclosed. K. Marsh (CB) Out - Undisclosed.

“I think for us, as complete of a game as we’ve played in terms of the ups and the downs, but continuing to play. There was so much in terms of mistakes and non-execution on all three sides of the ball, but we kept answering the bell.” - Alex Golesh after his team’s win against FAU in their last game. 

“I thought the guys had the right mindset to the bye week, the right approach to the game. I think this loss had nothing to do with their lack of execution. We got outcoached.” - Ryan Silverfield after his team’s loss against UAB in their last game. 

WR Nimrod, Chas

WR Singleton, Keshaun

WR Reuben, Mudia

TE Sullivan, Wyatt

QB Brown, Byrum

RB Franklin, Sam 

WR Braham Jr., Cortez

WR Bussey, Marcello

WR Hawkins, Jamari

TE Ross, Christian

QB Lewis, Brendon

RB Desrosiers Jr., Greg

Passing: Byrum Brown (1,695)

Rushing: Byrum Brown (475)

Receiving: Chas Nimrod (466)

Touchdowns: Byrum Brown (6)

Passing: Brendon Lewis (1,337)

Rushing: Sutton Smith (480)

Receiving: Cortez Braham Jr. (491)

Touchdowns: Brendon Lewis (7)

Coaches:

South Florida Bulls: Alex Golesh (3rd season)

Memphis Tigers: Ryan Silverfield (6th season)