South Florida Bulls vs Florida Gators Prediction, Picks and Game Preview - 09/06/2025

Game Time: 4:15 pm ET, Saturday, September 6, 2025

Venue:  Ben Hill Griffin Stadium, Gainesville, FL

Where to Watch:  SEC Network

DraftKings:  Point Spread:  USF +17.5, Florida -17.5; Over/Under:  54.5 points

Bet365:  Point Spread:  USF +17.5, Florida -17.5; Over/Under:  54.5 points

BetMGM:  Point Spread:  USF +17.5, Florida -17.5; Over/Under:  54.5 points

South Florida Bulls:  1-0 (0-0) (7th place, American)

Florida Gators:  1-0 (0-0) (3rd place, SEC)

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South Florida Bulls:  won their last game at home against the Boise State Broncos 34-7.

Florida Gators:  won their last game at home against the Long Island Sharks 55-0.

South Florida is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Boise State 34-7. Byrum Brown was the starting QB and he completed 16/24 passes for 210 passing yards, 0 touchdowns, and 0 interceptions. Alvon Isaac led the team in rushing yards with 52. Chas Nimrod led the receivers with 96 receiving yards on 3 receptions. De'Shawn Rucker led the defense in that game with 7 solo tackles and 4 assisted tackles while Rico Watson III led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

Florida is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against LIU 55-0. DJ Lagway was the starting QB and he completed 15/18 passes for 120 passing yards, 3 touchdowns, and 0 interceptions. Jadan Baugh led the team in rushing yards with 104 and 1 TD. Vernell Brown III led the receivers with 79 receiving yards on 3 receptions. Myles Graham led the defense in that game with 4 solo tackles and 1 assisted tackle while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

The current betting odds have South Florida listed as a 17.5 point underdog in this game according to Draftkings Sportsbook. South Florida is 1-0 overall and they looked great in their season opener. They were at home against Boise State who was in the CFP last season and they embarrassed them with a 34-7 win. Their defense looked great as Boise State just couldn't move the ball and their offense was really getting into a groove with all of the talent they have. Now they go on the road against a much better team from the SEC, but South Florida has a lot of high hopes this season and they are going to bring their best effort for an in-state rival. South Florida may have been at home in their first game too, but they were still tested against a very good program and passed with flying colors. Meanwhile, Florida is 1-0 overall and also looked great in their season opener, but they won at home against a team from the FCS, beating LIU 55-0, and they weren't really tested at all in that one. They get to be at home again for this one, but this is a much tougher team coming into town so this is going to be their first real test. South Florida has the talent on offense to put up some points here and their defense is much improved too. They also have a bit of a rest advantage since they played their season opener on Thursday. The best way to place a bet here is on South Florida to cover the spread in this game. 

South Florida Florida Prediction:  Our NCAAF Pick for Saturday, September 6, 2025 (4:15 pm ET start time) is Florida 35 South Florida 20.

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South Florida Bulls: 8-4 ATS in non-conference games. 8-3 ATS after playing a game at home. 7-4 ATS in games played on a grass field. 8-4 OVER in road lined games. 

Florida Gators: 1-4 ATS at home against American Athletic conference opponents. 27-37 ATS in a home game where the total is between 49.5 and 56. 7-3 OVER when the total is between 49.5 and 56.

South Florida Bulls:  None.

Florida Gators:  J. Grimsley (CB) Questionable - Undisclosed. B. Hanks III (CB) Questionable - Undisclosed. L. McCray (DL) Questionable - Undisclosed. O. Konanbanny (CB) Questionable - Undisclosed. T. Webb (RB) Questionable - Undisclosed. C. Banks (DL) Questionable - Leg. A. Mizell (WR) Questionable - Undisclosed. D. Wilson (WR) Questionable - Leg. K. Jackson (WR) Out - Knee. D. Lagway (QB) Probable - Leg.

“I told our team last night that this is going to be a display of our identity. We’ve worked. We’ve got a bunch of seniors that have been through a lot. Some that are in their sixth year here.” - Alex Golesh after his team’s win against BSU in their last game. 

“That was his first scrimmage, if you think about it. He'll get his rhythm. He'll continue to get better. I thought you saw him get better as he kind of got comfortable and settled in." - Billy Napier after his team’s win against LIU in their last game. 

WR Singleton, Keshaun

WR Reuben, Mudia

WR Smith, JeyQuan

TE Wolff, Weston

QB Brown, Byrum

RB Norton, Cartevious

WR Sturdivant, J. Michael

WR Mizell, Aidan

WR Wilson III, Eugene

TE Hansen, Hayden

QB Lagway, DJ

RB Baugh, Jadan

Passing: B. Brown (210)

Rushing: A. Isaac (52)

Receiving: C. Nimrod (96)

Touchdowns: B. Brown (2)

Passing: T. Jones Jr. (131)

Rushing: J. Baugh (104)

Receiving: V. Brown III (79)

Touchdowns: J. Baugh (1)

Coaches:

South Florida Bulls: Alex Golesh (3rd season)

Florida Gators: Billy Napier (4th season)