South Carolina Gamecocks vs Missouri Tigers Prediction, Picks and Game Preview - 09/20/2025

Game Time: 7:00 pm ET, Saturday, September 20, 2025

Venue:  Faurot Field at Memorial Stadium, Columbia, MO

Where to Watch:  ESPN

DraftKings:  Point Spread:  South Carolina +11.5, Mizzou -11.5; Over/Under:  47.5 points

Bet365:  Point Spread:  South Carolina +11.5, Mizzou -11.5; Over/Under:  47.5 points

BetMGM:  Point Spread:  South Carolina +11.5, Mizzou -11.5; Over/Under:  47.5 points

South Carolina Gamecocks:  2-1 (0-1) (15th place, SEC)

Missouri Tigers:  3-0 (0-0) (5th place, SEC)

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South Carolina Gamecocks:  lost their last game at home against the Vanderbilt Commodores 31-7.

Missouri Tigers:  won their last game at home against the Louisiana Ragin’ Cajuns 52-10.

South Carolina is entering this game with a 2-1 record overall and they have a 0-1 record in their conference games too. They are 1-1 in their home games, 0-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Vanderbilt 31-7. LaNorris Sellers was the starting QB and he completed 6/7 passes for 94 passing yards, 0 touchdowns, and 1 interception. Rahsul Faison led the team in rushing yards with 74 and 1 TD. Nyck Harbor led the receivers with 66 receiving yards on 4 receptions. Peyton Williams led the defense in that game with 7 solo tackles and 0 assisted tackles while Nick Barrett led the defense in sacks with 1. Justin Okoronkwo came away with the only interception for them in that one.

 

 

 

Missouri is entering this game with a 3-0 record overall and they have a 0-0 record in their conference games too. They are 3-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Louisiana-Lafayette 52-10. Beau Pribula was the starting QB and he completed 15/22 passes for 174 passing yards, 2 touchdowns, and 1 interception. Ahmad Hardy led the team in rushing yards with 250 and 3 TDs. Kevin Coleman Jr. led the receivers with 84 receiving yards on 8 receptions. Zion Young led the defense in that game with 2 solo tackles and 1 assisted tackle while Damon Wilson II and Khalil Jacobs each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Missouri listed as an 11.5 point favorite in this game according to Draftkings Sportsbook. Missouri has looked good in their games this season with their 3-0 record overall and their offense has been rolling in their games. They are off a 52-10 win over ULL and they have been putting up a ton of points in all 3 games. This is their first conference game of the season, but they do have a test under their belt already with a tough win over Kansas. They were down early in that one too, but they fought their way back with that great offense and were able to bury Kansas by the end of the game. Meanwhile, South Carolina has looked good in their games this season with their 2-1 record overall, but their 0-1 conference record has them right near the bottom of the SEC. They just took a bad 31-7 loss at home to Vanderbilt and they struggled in their 2 wins against weaker opponents too. Now they could be without their starting QB Sellers, but even when he has played this season, he hasn't looked great and is not living up to the hype surrounding him coming into the season. South Carolina's defense hasn't been bad, but they couldn't do much last week to keep Vandy from scoring when their offense wasn't performing, and they won't be able to do much on the road now against this better Mizzou offense. The best way to place a bet here is on Missouri to cover the spread in this game. 

South Carolina Missouri Prediction:  Our NCAAF Pick for Saturday, September 20, 2025 (7:00 pm ET start time) is Missouri 42 South Carolina 20.

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South Carolina Gamecocks: 3-6 ATS when playing against a top-level team (Win Pct. > 75%). 1-5 ATS versus good defensive teams - allowing 310 yards/game or less. 6-3 UNDER in road lined games. 10-4 UNDER after playing a game at home.

Missouri Tigers: 21-8 ATS in all lined games. 14-5 ATS as a favorite. 11-5 ATS against conference opponents. 8-2 ATS after scoring 37 points or more last game. 8-3 UNDER after a win by 17 or more points. 6-2 UNDER after allowing 14 points or less last game.

South Carolina Gamecocks:  J. Collier (CB) Questionable - Knee.

Missouri Tigers:  S. Horn (QB) Out - Leg. B. Craig (K) Out - Undisclosed.

“When you lose the leader of your football team and you lose your starting quarterback like that — and we were doing a lot of good things. I was pleased with a lot of the stuff we were doing offensively. I told the team at halftime that we’ve got to go out and continue to play good football, because we were doing a lot of really good stuff. But I don’t like the way that we started the second half offensively.” - Shane Beamer after his team’s loss against Vandy in their last game. 

“If I’m going to be real, obviously, their starting quarterback got dinged up, and he’s a really, really good player, so coming on the road in the SEC environment versus that front, we just felt like we needed to be very aggressive and relentless in our coverage. I don’t think we called much zone cover today. I think the first completion they had was zone, and that was about it." - Eli Drinkwitz after his team’s win against ULL in their last game. 

WR Harbor, Nyck

WR Rowe Jr., Brian

WR Bennett Jr., Mazeo

TE Hunt, Brady

QB Sellers, LaNorris

RB Faison, Rahsul

WR Johnson, Marquis

WR Manning, Joshua

WR Coleman Jr., Kevin

TE Norfleet, Brett

QB Pribula, Beau

RB Hardy, Ahmad

Passing: L. Sellers (431)

Rushing: R. Faison (135)

Receiving: N. Harbor (165)

Touchdowns: N. Harbor (1)

Passing: B. Pribula (791)

Rushing: A. Hardy (462)

Receiving: K. Coleman Jr. (258)

Touchdowns: A. Hardy (5)

Coaches:

South Carolina Gamecocks: Shane Beamer (5th season)

Missouri Tigers: Eli Drinkwitz (6th season)