by Rod Pearson
Thursday, Oct 09, 2025
Game Time: 7:45 pm ET, Saturday, October 11, 2025
Venue: Tiger Stadium, Baton Rouge, LA
Where to Watch: SEC Network
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: South Carolina +8.5, LSU -8.5; Over/Under: 44.5 points
Bet365: Point Spread: South Carolina +9, LSU -9; Over/Under: 44 points
BetMGM: Point Spread: South Carolina +9.5, LSU -9.5; Over/Under: 44.5 points
Season Record
South Carolina Gamecocks: 3-2 (1-2) (11th place, SEC)
LSU Tigers: 4-1 (1-1) (9th place, SEC)
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South Carolina Gamecocks: won their last game at home against the Kentucky Wildcats 35-13.
LSU Tigers: lost their last game on the road against the Mississippi Rebels 24-19.
South Carolina Gamecocks vs LSU Tigers Preview and Analysis
South Carolina is entering this game with a 3-2 record overall and they have a 1-2 record in their conference games too. They are 2-1 in their home games, 0-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Kentucky 35-13. LaNorris Sellers was the starting QB and he completed 11/14 passes for 153 passing yards, 0 touchdowns, and 0 interceptions. LaNorris Sellers led the team in rushing yards with 81. Vandrevius Jacobs led the receivers with 108 receiving yards on 5 receptions. Bryan Thomas Jr. led the defense in that game with 5 solo tackles and 2 assisted tackles while Bryan Thomas Jr. led the defense in sacks with 2. Brandon Cisse and Gerald Kilgore each came away with 1 interception for them in that one.
LSU is entering this game with a 4-1 record overall and they have a 1-1 record in their conference games too. They are 3-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Ole Miss 24-19. Garrett Nussmeier was the starting QB and he completed 21/34 passes for 197 passing yards, 1 touchdown, and 1 interception. Harlem Berry led the team in rushing yards with 22 and 1 TD. Zavion Thomas led the receivers with 63 receiving yards on 3 receptions. A.J. Haulcy led the defense in that game with 9 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. PJ Woodland came away with the only interception for them in that one.
South Carolina vs LSU Prediction
The current betting odds have LSU listed as an 8.5 point favorite in this game according to Draftkings Sportsbook. LSU has looked really good in their games this season with their 4-1 record overall which has them ranked inside the top 25. They have a 1-1 conference record which has them lower in the SEC, but they just took their first loss of the season on the road against a really good Ole Miss team. LSU has looked great on defense this season and they haven't been giving up many points in their games, but their offense has been a big issue. They will be looking to bounce back at home though and they are coming out of their bye week here so they have had extra time to fix the things on offense that they have been struggling with and they will look a lot better coming out of their bye. Meanwhile, South Carolina hasn't looked good in their games this season with their 3-2 record overall and their 1-2 conference record which has them near the bottom of the SEC. They have had a really rough start to the season as they were ranked preseason and have fallen far from that. They are off a 35-13 win over Kentucky and have had a bye week to sort things out, but they have struggled against some bad opponents this season. Sellers hasn't really lived up to his hype either and that will be a big issue against this LSU defense. Both of these offenses have struggled this season, but LSU has a lot more talent to right the ship on offense coming out of the bye week and they also have the better defense. The best way to place a bet here is on LSU to cover the spread in this game.
South Carolina LSU Prediction: Our NCAAF Pick for Saturday, October 11, 2025 (7:45 pm ET start time) is LSU 24 South Carolina 10.
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NCAAF Betting Trends
South Carolina Gamecocks: 8-2 ATS in road lined games. 7-2 ATS when the total is between 42.5 and 49. 10-5 ATS after playing a game at home. 9-2 UNDER off a home win. 6-0 UNDER off a home win by 17 points or more.
LSU Tigers: 3-6 ATS after playing their last game on the road. 16-24 ATS at home off a road loss against a conference rival. 5-11 ATS at home versus poor offensive teams - averaging 310 yards/game or less. 17-5 UNDER at home after a bye week.
Key Injuries
South Carolina Gamecocks: T. Pikes (DL) Questionable - Undisclosed. J. Collier (CB) Questionable - Undisclosed. M. Norwood (CB) Questionable - Undisclosed. M. Anderson (OG) Out - Undisclosed. C. Henry (OG) Doubtful - Undisclosed. N. Hay (OG) Doubtful - Undisclosed.
LSU Tigers: P. Mubenga (OG) Doubtful - Undisclosed. A. Breaux (DL) Probable - Undisclosed. C. Durham (RB) Probable - Ankle. G. Reliford (DL) Out - Undisclosed. A. Anderson (WR) Questionable - Hip/Knee. J. Lindsey (RB) Out - Suspension.
Notable Quotes
“Obviously when you score twice on defense, you’re going to be really hard to beat. We didn’t just want to win the turnover battle, we wanted to dominate it.” - Shane Beamer after his team’s win against Kentucky in their last game.
“Look, Garrett Nussmeier has got to play better. Every player on offense has got to play better — and then we have to be more consistent on defense. There's many players that have to play their best when their best is needed.” - Brian Kelly after his team’s loss against Ole Miss in their last game.
Starting Lineups
South Carolina Gamecocks
WR Harbor, Nyck
WR Jacobs, Vandrevius
WR Rowe Jr., Brian
TE Hunt, Brady
QB Sellers, LaNorris
RB Faison, Rahsul
LSU Tigers
WR Thomas, Zavion
WR Brown, Barion
WR Anderson, Aaron
TE Sharp, Bauer
QB Nussmeier, Garrett
RB Durham, Caden
Statistical Leaders
South Carolina Gamecocks
Passing: LaNorris Sellers (886)
Rushing: Rahsul Faison (163)
Receiving: Vandrevius Jacobs (323)
Touchdowns: Rahsul Faison (3)
LSU Tigers
Passing: Garrett Nussmeier (1,159)
Rushing: Caden Durham (213)
Receiving: Aaron Anderson (305)
Touchdowns: Caden Durham (2)
Coaches:
South Carolina Gamecocks: Shane Beamer (5th season)
LSU Tigers: Brian Kelly (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
