Seattle Seahawks vs Jacksonville Jaguars Prediction, Preview and Odds - 10/12/2025

Game Time: 1:00 pm ET, Sunday, October 12, 2025

Venue:  EverBank Stadium, Jacksonville, FL

Where to Watch:  FOX

DraftKings:  Point Spread:  Seahawks +1.5, Jaguars -1.5; Over/Under:  47.5 points

Bet365:  Point Spread:  Seahawks +1, Jaguars -1; Over/Under:  47.5 points

BetMGM:  Point Spread:  Seahawks +1, Jaguars -1; Over/Under:  47.5 points

Seattle Seahawks:  3-2 (2nd place, NFC West)

Jacksonville Jaguars:  4-1 (2nd place, AFC South)

Do not miss out on our expert handicapper analysis! Brian Bitler is on a HOT STREAK in the NFL on a 5-0 NFL RUN for +$5,000 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Seattle Seahawks:  lost their last game at home against the Tampa Bay Buccaneers 38-35.

Jacksonville Jaguars:  won their last game at home against the Kansas City Chiefs 31-28.

The Seahawks are entering this game with a 3-2 record overall and they have a 1-1 record in their divisional games too. They are 1-2 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Tampa Bay Buccaneers 38-35. Sam Darnold was the starting QB and he completed 28/34 passes for 341 passing yards, 4 touchdowns, and 1 interception. Kenneth Walker III led the team in rushing yards with 86. Jaxon Smith-Njigba led the receivers with 132 receiving yards on 8 receptions and 1 TD. Coby Bryant led the defense in that game with 7 solo tackles and 1 assisted tackle while Uchenna Nwosu and D'Anthony Bell each led the defense in sacks with 0.5. No one on the defense came away with an interception for them in that one.

 

 

 

The Jaguars are entering this game with a 4-1 record overall and they have a 1-0 record in their divisional games too. They are 3-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Kansas City Chiefs 31-28. Trevor Lawrence was the starting QB and he completed 18/25 passes for 221 passing yards, 1 touchdown, and 1 interception. Trevor Lawrence led the team in rushing yards with 54 and 2 TDs. Brian Thomas Jr. led the receivers with 80 receiving yards on 4 receptions. Foyesade Oluokun led the defense in that game with 7 solo tackles and 7 assisted tackles while no one on the defense recorded a sack for them. Devin Lloyd came away with the only interception for them in that one.

The current betting odds have the Seahawks listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The Seahawks have looked good in their games this season with their 3-2 record overall which has them right in the NFC West race early on. They are off a 38-35 loss to the Buccaneers at home in their last one, but they will be looking to bounce back now that their offense has found some life. The offense hasn't been great to start the season, but they finally looked good against a good Bucs defense and they are going to build on that performance. Their defense didn't look good at all, but they have had one of the best defenses in the NFL through the first 4 weeks so they are going to bounce back with a better performance. Meanwhile, the Jaguars have looked great in their games this season with their 4-1 record overall which has them right near the top of the AFC South. They have looked really good this year with their defense playing a lot better and the offense looking very different with their new head coach. They are off a huge home win over the Chiefs in their last one, beating them on Monday night 31-28, but now they are in a tough situation. They are still at home for this game, but they are on a shorter week with that game being on Monday and that is still a really big win for them to come down from. The Seahawks are a really good team coming off a loss and they can catch this Jaguars team that has been flying too high lately. The best way to place a bet here is on the Seahawks to cover the spread in this game. 

Seahawks Jaguars Prediction:  Our NFL Pick for Sunday, October 12, 2025 (1:00 pm ET start time) is Seahawks 27 Jaguars 24.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Seattle Seahawks Jacksonville Jaguars prediction, be sure to drop by every day for our weekly NFL predictions and previews.

Seattle Seahawks: 3-6 ATS in non-conference games. 1-8 ATS versus poor rushing defenses - allowing 4.5 rushing yards/carry or more. 12-4 UNDER in games where the line is +3 to -3. 9-4 UNDER in a road game where the total is between 42.5 and 49 points. 7-3 UNDER versus good rushing teams - averaging 4.5 rushing yards/carry or more.

Jacksonville Jaguars: 15-8 ATS in all games where the total is between 42.5 and 49 points. 8-4 ATS in non-conference games. 9-2 ATS when playing against a good team (Win Pct. 60% to 75%). 12-4 UNDER in games where the line is +3 to -3. 7-4 UNDER when playing against a good team (Win Pct. 60% to 75%).

Seattle Seahawks:  N. Emmanwori (S) Injured - Ankle. D. Hall (LB) Injured - Oblique. E. Jones IV (LB) Injured - Shoulder. J. Jones (OG) Injured - Ankle. D. Lawrence (LB) Injured - Quadricep. J. Love (S) Injured - Hamstring. J. Reed (DL) Injured - Rest. B. Russell (FB) Injured - Wrist. D. Witherspoon (CB) Injured - Knee. R. Woolen (CB) Injured - Concussion.

Jacksonville Jaguars:  E. Murray (S) Injured - Neck. L. Cooke (P) Injured - Personal. E. Cleveland (OG) Injured - Ankle. C. Edoga (OG) Injured - Knee. R. Hainsey (C) Injured - Hamstring. P. Mekari (OG) Injured - Knee. Y. Abdullah (LB) Injured - Hamstring. D. Brown (WR) Injured - Shoulder. T. Walker (DL) Injured - Wrist. A. Harrison (OG) Injured - Elbow. B. Tuten (RB) Injured - Shoulder.

“I have to do better with our defensive game plan and execution and how we call it. When you put up a performance like that, it means that I didn’t prepare them well enough. It hurts. It stings.” - Mike Macdonald after his team’s loss against the Buccaneers in their last game. 

“We like to make things very interesting. But the resiliency is really what I think this team has." - Liam Coen after his team’s win against the Chiefs in their last game. 

WR Horton, Tory

WR Smith-Njigba, Jaxon

WR Kupp, Cooper

TE Barner, AJ 

QB Darnold, Sam

RB Walker III, Kenneth

FB Russell, Brady

WR Thomas Jr., Brian

WR Brown, Dyami

WR Hunter, Travis

TE Long, Hunter

QB Lawrence, Trevor 

RB Etienne Jr., Travis

Passing: Sam Darnold (1,246)

Rushing: Kenneth Walker III (330)

Receiving: Jaxon Smith-Njigba (534)

Touchdowns: AJ Barner (4)

Passing: Trevor Lawrence (1,066)

Rushing: Travis Etienne Jr. (443)

Receiving: Brian Thomas Jr. (244)

Touchdowns: Travis Etienne Jr. (3)

Coaches:

Seattle Seahawks: Mike Macdonald (2nd season)

Jacksonville Jaguars: Liam Coen (1st season)