by Rod Pearson
Tuesday, Sep 23, 2025
Game Time: 8:15 pm ET, Thursday, September 25, 2025
Venue: State Farm Stadium, Glendale, AZ
Where to Watch: Prime Video
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Seahawks -1.5, Cardinals +1.5; Over/Under: 43.5 points
Bet365: Point Spread: Seahawks -1, Cardinals +1; Over/Under: 43.5 points
BetMGM: Point Spread: Seahawks -1, Cardinals +1; Over/Under: 43.5 points
Season Record
Seattle Seahawks: 2-1 (3rd place, NFC West)
Arizona Cardinals: 2-1 (2nd place, NFC West)
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Recent Form
Seattle Seahawks: won their last game at home against the New Orleans Saints 44-13.
Arizona Cardinals: lost their last game on the road against the San Francisco 49ers 16-15.
Seattle Seahawks vs Arizona Cardinals Preview and Analysis
The Seahawks are entering this game with a 2-1 record overall and they have a 0-1 record in their divisional games too. They are 1-1 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New Orleans Saints 44-13. Sam Darnold was the starting QB and he completed 14/18 passes for 218 passing yards, 2 touchdowns, and 0 interceptions. Kenneth Walker III led the team in rushing yards with 38 and 2 TDs. Jaxon Smith-Njigba led the receivers with 96 receiving yards on 5 receptions and 1 TD. Josh Jobe led the defense in that game with 9 solo tackles and 2 assisted tackles while Byron Murphy II led the defense in sacks with 1. Derion Kendrick came away with the only interception for them in that one.
The Cardinals are entering this game with a 2-1 record overall and they have a 0-1 record in their divisional games too. They are 1-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the San Francisco 49ers 16-15. Kyler Murray was the starting QB and he completed 22/35 passes for 159 passing yards, 1 touchdown, and 0 interceptions. Trey Benson led the team in rushing yards with 42. Marvin Harrison Jr. led the receivers with 44 receiving yards on 3 receptions. Mack Wilson Sr. led the defense in that game with 6 solo tackles and 6 assisted tackles while Josh Sweat led the defense in sacks with 1. Dadrion Taylor-Demerson came away with the only interception for them in that one.
Seahawks vs Cardinals Prediction
The current betting odds have the Seahawks listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The Seahawks have looked good in their games this season with their 2-1 record overall. They lost their season opener to the 49ers, but now they have been figuring things out and have won 2 games in a row. Their offense has looked a lot better over their last 2 games, but their defense has been the real star of this team through 3 weeks. Meanwhile, the Cardinals have looked good in their games this season with their 2-1 record overall. Their wins weren't that impressive though as they beat up on 2 of the worst teams in the NFL, beating the Saints and the Panthers, and they almost blew that game against the Panthers late too. Now they are off a tight loss to the 49ers in their last one and that was against a banged up 49ers team missing their starting QB along with other key players. The defense has been really good for the Cardinals this season and they are going to be clinging onto this game for them, but the offense just hasn't looked good and this is a really good Seahawks defense that will be tough for them to score on. These two teams may have the same record, but the Seahawks are the better team with some momentum on their side and this is a big divisional game for them to make a statement in. The best way to place a bet here is on the Seahawks to cover the spread in this game.
Seahawks Cardinals Prediction: Our NFL Pick for Thursday, September 25, 2025 (8:15 pm ET start time) is Seahawks 24 Cardinals 17.
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NFL Betting Trends
Seattle Seahawks: 1-5 ATS after allowing 14 points or less last game. 1-4 ATS vs. poor passing teams averaging 5.7 or less passing yards/att. 4-7 ATS when playing against a good team (Win Pct. 60% to 75%). 45-21 OVER vs. good defensive teams who give up 17 or less points/game.
Arizona Cardinals: 22-15 ATS in all games. 19-13 ATS in all games where the total is between 42.5 and 49 points. 9-4 ATS off a road loss. 12-5 OVER in home games. 11-4 OVER in a home game where the total is between 42.5 and 49 points.
Key Injuries
Seattle Seahawks: R. Ouzts (FB) Injured - Ankle. J. Sundell (C) Injured - Ankle. L. Williams (DL) Injured - Elbow. E. Arroyo (TE) Injured - Groin. J. Jones (OG) Injured - Ankle. B. Mafe (LB) Injured - Toe. Z. Charbonnet (RB) Injured - Foot. N. Emmanwori (S) Injured - Ankle. E. Jones IV (LB) Injured - Shoulder. J. Love (S) Injured - Hamstring. D. Witherspoon (CB) Injured - Knee.
Arizona Cardinals: Z. Jones (WR) Injured - Concussion. J. Conner (RB) Injured - Foot. E. Brown (OG) Injured - Ankle. D. Hall (CB) Injured - Ankle. A. Davis-Gaither (LB) Injured - Elbow. K. Beachum (OG) Injured - Knee. W. Hernandez (OG) Injured - Knee. P. Johnson Jr. (OG) Injured - Knee. W. Johnson (CB) Injured - Groin.
Notable Quotes
“I know that he’s continuing to get better. And I think that’s the biggest key as a young player is having that want to get better and understand the offense even that much more.” - Sam Darnold on Tory Horton after their win against the Saints in their last game.
“The defense did enough for us to win the game and we didn’t finish the job. Myself included, we just have to be better. When you’re playing better teams, playing better opponents, you can’t afford to let those happen.” - Kyler Murray after his team’s loss against the 49ers in their last game.
Starting Lineups
Seattle Seahawks
WR Horton, Tory
WR Smith-Njigba, Jaxon
WR Kupp, Cooper
TE Barner, AJ
QB Darnold, Sam
RB Walker III, Kenneth
FB Russell, Brady
Arizona Cardinals
WR Harrison Jr., Marvin
WR Weaver, Xavier
WR Wilson, Michael
TE McBride, Trey
QB Murray, Kyler
RB Benson, Trey
Statistical Leaders
Seattle Seahawks
Passing: Sam Darnold (663)
Rushing: Kenneth Walker III (163)
Receiving: Jaxon Smith-Njigba (323)
Touchdowns: Kenneth Walker III (3)
Arizona Cardinals
Passing: Kyler Murray (542)
Rushing: Trey Benson (125)
Receiving: Trey McBride (182)
Touchdowns: James Conner (2)
Coaches:
Seattle Seahawks: Mike Macdonald (2nd season)
Arizona Cardinals: Jonathan Gannon (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
