Seattle Seahawks vs Arizona Cardinals Prediction, Preview and Odds - 09/20/2026

Game Time: 4:25 pm ET, Sunday, September 20, 2026

Venue:  State Farm Stadium, Glendale, AZ

Where to Watch:  FOX

DraftKings:  Point Spread:  Seahawks -3.5, Cardinals +3.5; Over/Under:  40.5 points

Bet365:  Point Spread:  Seahawks -4, Cardinals +4; Over/Under:  40.5 points

BetMGM:  Point Spread:  Seahawks -4, Cardinals +4; Over/Under:  40.5 points

Seattle Seahawks:  1-0 (1st place, NFC West)

Arizona Cardinals:  1-0 (1st place, NFC West)

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Seattle Seahawks:  won their last game at home against the New England Patriots 13-10.

Arizona Cardinals:  won their last game on the road against the Los Angeles Chargers 26-14.

The Seahawks are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New England Patriots 13-10. Sam Darnold was the starting QB and he completed 1/2 passes for 13 passing yards before leaving injured and getting replaced by Drew Lock who completed 16/22 passes for 187 yards, 1 touchdown, and 0 interceptions. Jadarian Price led the team in rushing yards with 52. Jaxon Smith-Njigba led the receivers with 122 receiving yards on 8 receptions and 1 TD. Ernest Jones IV led the defense in that game with 13 solo tackles while Drake Thomas, Leonard Williams, and Derick Hall each led the defense in sacks with 1. Josh Jobe, Julian Love, and Nehemiah Pritchett each came away with 1 interception for them in that one.

 

 

 

The Cardinals are entering this game with a 1-0 record overall and they have a 0-0 record in their divisional games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Los Angeles Chargers 26-14. Jacoby Brissett was the starting QB and he completed 27/37 passes for 277 passing yards, 1 touchdown, and 0 interceptions. Tyler Allgeier led the team in rushing yards with 61. Trey McBride led the receivers with 95 receiving yards on 9 receptions and 1 TD. Jack Gibbens led the defense in that game with 7 solo tackles while Jordan Burch and Dante Stills each led the defense in sacks with 1. Andrew Wingard came away with the only interception for them in that one.

The current betting odds have the Cardinals listed as a 3.5 point underdog in this game according to Draftkings Sportsbook. The Cardinals have looked good in their games this season with their 1-0 record overall so far. They haven't played any home games yet and will be playing their home opener here. Meanwhile, the Seahawks have looked good in their games this season with their 1-0 record overall so far. They haven't played any road games though and will be playing their 1st road game of the year here. The Seahawks are coming off a 13-10 win over the Patriots in their last one and their defense looked great in that win, but their offense did not. Sam Darnold left the game early with an injury and Drew Lock had a lot of trouble getting them going until late in the game. Lock ended up doing enough on offense to get them the win, but the defense really picked the team up late in that game and set themselves up to win that one. Now Darnold will be missing this game and the Cardinals looked really good in their 1st game of the Mike LaFleur era. They pulled off a 26-14 upset win over the Chargers who are a playoff team and they won that game on the road too. The defense did a lot of good things to give the Chargers issues and the offense does have some talent in it too. They can actually run the ball now with their new draft pick and there is plenty of talent for Brissett to throw the ball to. The Cards are entering this game with a ton of momentum from that unexpected win and they did play the Seahawks really tough in both games last season when the Cardinals were a lot worse. Look for the Cardinals to take advantage of Darnold being out and pull off another upset win over the Super Bowl champions as the Seahawks offense continues to have issues. The best way to place a bet here is on the Cardinals to cover the spread in this game. 

Seahawks Cardinals Prediction:  Our NFL Pick for Sunday, September 20, 2026 (4:25 pm ET start time) is Cardinals 17 Seahawks 14.

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Seattle Seahawks: 12-4 ATS in road games. 6-1 ATS as a road favorite of 7 points or less. 8-4 ATS after allowing 14 points or less last game. 8-4 OVER as a favorite of 3.5 to 9.5 points. 9-4 OVER in all games where the total is between 35.5 and 42 points.

Arizona Cardinals: 41-60 ATS after allowing 14 points or less last game. 44-62 ATS after a game with a turnover margin of +2 or better. 11-6 OVER in home games. 9-5 OVER after playing their last game on the road.

Seattle Seahawks:  S. Darnold (QB) Injured - Glute. T. Okada (S) Injured - Hamstring. A. Bradford (OG) Injured - Knee. N. Emmanwori (S) Injured - Ankle. J. Jones (OG) Injured - Knee. C. Kupp (WR) Injured - Back. T. Horton (WR) Injured - Hamstring. J. Jobe (CB) Injured - Wrist.

Arizona Cardinals:  A. Billings (DL) Injured - Knee. I. Adams (OG) Injured - Knee. J. Gibbens (LB) Injured - Shoulder. R. Lopez (DL) Injured - Groin. M. Melton (CB) Injured - Ankle. C. Simon (LB) Injured - Shoulder. D. Taylor-Demerson (S) Injured - Ribs. G. Williams (CB) Injured - Achilles. B. Baker (S) Injured - Rest. T. McBride (TE) Injured - Back. I. Seumalo (OG) Injured - Shoulder. J. Sweat (LB) Injured - Rest.

“I want to give our team a lot of credit because you know things weren’t really going where we wanted. We didn’t panic. We still liked our plan. We didn’t need to change what we were doing or anything like that. We just we wanted to stick to what we were doing, and the guys were just really excited to go back out there and play.” - Mike Macdonald after his team’s win against the Patriots in their last game. 

“These last few days have been almost miserable waiting. Just really happy for those guys.” - Mike LaFleur after his team’s win against the LA Chargers in their last game. 

WR Smith-Njigba, Jaxon

WR Shaheed, Rashid

WR Kupp, Cooper

TE Barner, AJ 

QB Lock, Drew

RB Price, Jadarian

FB Russell, Brady

WR Harrison Jr., Marvin

WR Wilson, Michael

WR Bourne, Kendrick

TE McBride, Trey

QB Brissett, Jacoby

RB Allgeier, Tyler

Passing: Drew Lock (187)

Rushing: Jadarian Price (52)

Receiving: Jaxon Smith-Njigba (122)

Touchdowns: Jaxon Smith-Njigba (1)

Passing: Jacoby Brissett (277)

Rushing: Tyler Allgeier (61)

Receiving: Trey McBride (95)

Touchdowns: Trey McBride (1)

Coaches:

Seattle Seahawks: Mike Macdonald (3rd season)

Arizona Cardinals: Mike LaFleur (1st season)