Seattle Mariners vs Pittsburgh Pirates Prediction, Preview and Odds - 06/24/2026

Game Time: 6:40 pm ET, Wednesday, June 24, 2026

Venue:  PNC Park, Pittsburgh, PA 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Mariners -102, Pirates -118; Over/Under:  7 runs

Bet365:  Moneyline odds:  Mariners +100, Pirates -120; Over/Under:  7 runs

BetMGM:  Moneyline odds:  Mariners -105, Pirates -115; Over/Under:  7 runs

Seattle Mariners:  40-39 (1st place, AL West)

Pittsburgh Pirates:  39-39 (4th place, NL Central)

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Seattle Mariners:  4-6 last 10

Pittsburgh Pirates:  4-6 last 10

The Mariners are entering this series off a win and lost their 3-game series against the Boston Red Sox 2-1 in their last series. They enter this game with a 40-39 record overall and have a road record of 18-20. This is the 2nd game of a 3-game series with the Pirates on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 23rd in the MLB with a .700 OPS. George Kirby is their starting pitcher on Tuesday while Bryan Woo is making his start in this game on Wednesday. He is 6-5 with a 3.94 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 1 BB with 9 SO on 3 hits through 7 IP against the Baltimore Orioles.

The Pirates are entering this series off a win and lost their 3-game series against the Colorado Rockies 2-1 in their last series. They enter this game with a 39-39 record overall and have a home record of 20-19. This is the 2nd game of a 3-game series with the Mariners on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 4th in the MLB with a .744 OPS. Mitch Keller is their starting pitcher on Tuesday while Braxton Ashcraft is making his start in this game on Wednesday. He is 6-3 with a 3.18 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 3 walks with 7 strikeouts on 4 hits through 6 innings pitched against the Athletics.

The current betting odds have the Pirates listed as a slight favorite in this game according to Draftkings Sportsbook. The Mariners have looked good in their games this season with their 40-39 record overall which has them right at the top of the AL West. They haven't been a great road team though with their 18-20 road record this year. Meanwhile, the Pirates have looked good in their games this season with their 39-39 record overall, but that record has them right near the bottom of the NL Central. They have looked better in their own ballpark with their 20-19 home record this season. Neither team has looked great lately as both are 4-6 in their last 10 games respectively, but the Pirates do have the better pitching matchup in this one and they can take advantage of that since they also have the better offense. The Mariners are going with Woo in this one and he hasn't looked bad this season. He is 6-5 with a 3.94 ERA and he hasn't been giving up many runs lately, but he has also been really up and down all year and the team hasn't had much success with him lately. He is coming off a great start in which he gave up no runs, but that hasn't been a common theme for him this year and the team has lost 2 games in a row now with him starting. The Pirates are going with Ashcraft in this one and he has looked great this season. He is 6-3 with a 3.18 ERA and he has been one of their best starters this year. His team has lost 2 of their last 3 games with him starting, but he only gave up 1 earned run in his last start and that has been a common theme for him. The Pirates have the edge at home with the better starter here and they also have the much better offense this season, the Mariners not putting up a lot of runs lately either. The best way to place a bet here is on the Pirates to win this game. 

Mariners Pirates Prediction:  Our MLB Pick for Wednesday, June 24, 2026 (6:40 pm ET start time) is Pirates 4 Mariners 1.

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Seattle Mariners: 22-11 (+10 units) on the moneyline against NL Central opponents. 124-91 (+14.1 units) on the moneyline when the total is 7 to 7.5. 26-15 (+5 units) on the moneyline vs. NL teams allowing 4.5 or more runs/game on the season. 69-43 OVER on the road when the money line is +125 to -125.

Pittsburgh Pirates: 187-215 (-20.8 units) on the moneyline in all games. 52-62 (-8.8 units) on the moneyline in an inter-league game. 143-157 (-7.7 units) on the moneyline against right-handed starters. 26-13 OVER in home games.

Seattle Mariners:  L. Raley (RF) Day To Day - Back. R. Arozarena (LF) Ten Day IL - Leg. W. Wilson (3B) Sixty Day IL - Thumb. M. Brash (RP) Fifteen Day IL - Lat. C. Criswell (RP) Fifteen Day IL - Shoulder. B. Donovan (3B) Ten Day IL - Groin. C. Vargas (RP) Sixty Day IL - Lat. L. Evans (SP) Sixty Day IL - Arm.

Pittsburgh Pirates:  J. Jones (1B) Day To Day - Arm. W. Dotel (RP) Fifteen Day IL - Lat. O. Cruz (CF) Ten Day IL - Hand. C. Devenski (RP) Sixty Day IL - Illness. K. Griffin (SS) Ten Day IL - Flexor Tendon.

“Cal did a good job - like, [with two strikes] I think slider right away, probably. And he went to curveball a few times with two strikes. I think that was smart, looking back afterwards. If guys are kind of in-between bat speed you don’t really want to give them a gift, something at 90 or whatever. So the curveball at 81, if you’re keeping the same hand speed and everything. I think it does a good job fooling them.” - Logan Gilbert after their win against the Red Sox in their game on Sunday. 

"No lead is safe here. We've seen that before. The game can turn in a hurry, so all the insurance runs you can get here are big. (The home run) felt great. I felt like it was flush and a good, true homer. Nice one to watch." - Bryan Reynolds after their win against the Rockies in their game on Sunday. 

J.P. Crawford (L) SS

Cal Raleigh (S) C

Julio Rodríguez (R) CF

Josh Naylor (L) 1B

Rob Refsnyder (R) DH

Dominic Canzone (L) RF

Victor Robles (R) LF

Weston Wilson (R) 3B

Cole Young (L) 2B

Spencer Horwitz (L) 1B

Brandon Lowe (L) 2B

Bryan Reynolds (S) DH

Ryan O'Hearn (L) RF

Nick Gonzales (R) 3B

Endy Rodríguez (S) C

Tyler Callihan (L) LF

Jake Mangum (S) CF

Jared Triolo (R) SS

Batting Average:  Randy Arozarena (.291)

Hits:  Julio Rodríguez (77)

Home Runs:  Luke Raley (14)

RBI:  Julio Rodríguez (37)

Stolen Bases:  Randy Arozarena (19)

Wins:  Logan Gilbert (6)

Saves:  Andrés Muñoz (13)

ERA:  Nick Davila (0.00)

Batting Average:  Rafael Flores (.667)

Hits:  Bryan Reynolds (80)

Home Runs:  Brandon Lowe (18)

RBI:  Bryan Reynolds (51)

Stolen Bases:  Oneil Cruz (21)

Wins:  Paul Skenes (6)

Saves:  Gregory Soto (11)

ERA:  Evan Sisk (1.85)

Managers:

Seattle Mariners: Dan Wilson (3rd season)

Pittsburgh Pirates: Don Kelly (2nd season)