Seattle Mariners vs Philadelphia Phillies Prediction, Preview and Odds - 08/20/2025

Game Time: 1:05 pm ET, Wednesday, August 20, 2025

Venue:  Citizens Bank Park, Philadelphia, PA 

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Mariners +118, Phillies -144; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Mariners +120, Phillies -140; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Mariners +120, Phillies -140; Over/Under:  8.5 runs

Seattle Mariners:  68-58 (2nd place, AL West)

Philadelphia Phillies:  72-53 (1st place, NL East)

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Seattle Mariners:  5-5 last 10

Philadelphia Phillies:  6-4 last 10

The Mariners are entering this series off a loss and lost their 3-game series against the New York Mets 2-1 in their last series. They enter this game with a 68-58 record overall and have a road record of 31-33. This is the series finale of a 3-game series with the Phillies on Wednesday with the 2nd game still to be played on Tuesday. The Mariners lost the series opener on Monday. Their offense ranks 12th in the MLB with a .731 OPS. Bryce Miller is their starting pitcher on Tuesday while Luis Castillo is making his start in this game on Wednesday. He is 8-6 with a 3.48 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 6 ER, 3 HR, and 1 BB with 5 SO on 9 hits through 4 IP against the New York Mets.

The Phillies are entering this series off a win and split their 4-game series against the Washington Nationals 2-2 in their last series. They enter this game with a 72-53 record overall and have a home record of 38-21. This is the 3rd game of a 3-game series with the Mariners on Wednesday with the 2nd game of this series still to be played on Tuesday. The Phillies won the 1st game of this series on Monday. Their offense ranks 8th in the MLB with a .743 OPS. Cristopher Sánchez is their starting pitcher on Tuesday while Jesús Luzardo is making his start in this game on Wednesday. He is 11-6 with a 4.21 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 1 homer, and 3 walks with 7 strikeouts on 4 hits through 6 innings pitched against the Washington Nationals.

The current betting odds have the Phillies listed as a favorite in this game according to Draftkings Sportsbook. The Phillies have looked great in their games this season with their 72-53 record overall which has them right at the top of the NL East. They have looked great in their own ballpark this year too with their 38-21 home record. Meanwhile, the Mariners have looked good in their games this season with their 68-58 record overall which has them right near the top of the AL West. They haven't been a great road team though with their 31-33 road record this season. The Mariners have been starting to cool off lately as they are only 5-5 in their last 10 games while the Phillies are 6-4 and have been getting hot once again. The Phillies are going with Luzardo in this one and he hasn't looked bad this season. He is 11-6 with a 4.21 ERA and was great for most of the season before starting to fall apart over the last month. He is starting to get back in a rhythm though, coming off a better start in which he gave up 3 earned runs, and the team has still been having success with him lately as they have won 3 of their last 4 games with him starting. The Mariners are going with Castillo in this one and he has been a solid starter this year. He is 8-6 with a 3.48 ERA, but lately he has been giving up more runs in his starts and he hasn't looked great in road starts either. The team has still won 2 games in a row with him starting, but he is coming off a terrible start in which he gave up 6 earned runs and that is going to be an issue here since the Phillies have one of the best offenses in the MLB and have been getting hot lately. All signs point to the Phillies in this one as these two teams continue to head in different directions. The best way to place a bet here is on the Phillies to win this game. 

Mariners Phillies Prediction:  Our MLB Pick for Wednesday, August 20, 2025 (1:05 pm ET start time) is Phillies 8 Mariners 4.

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Seattle Mariners: 19-21 (-10.7 units) on the moneyline against NL East opponents. 241-209 (-10.8 units) on the moneyline in all games. 110-116 (-14.1 units) on the moneyline in road games. 28-18 OVER as an underdog of +125 to +175.

Philadelphia Phillies: 267-200 (+5.9 units) on the moneyline in all games. 149-83 (+24.7 units) on the moneyline in home games. 215-131 (+13.6 units) on the moneyline as a favorite of -110 or higher. 64-48 OVER vs. good power teams - averaging 1.25 or more HR's/game.

Seattle Mariners:  D. Canzone (RF) Day To Day - Arm. L. Evans (SP) Fifteen Day IL - Elbow. T. Thornton (RP) Fifteen Day IL - Achilles. B. Miller (SP) Fifteen Day IL - Elbow. G. Santos (RP) Sixty Day IL - Knee. V. Robles (RF) Sixty Day IL - Shoulder. R. Bliss (2B) Sixty Day IL - Biceps.

Philadelphia Phillies:  Z. Wheeler (SP) Fifteen Day IL - Blood Clot.

“We just don't see that often from Logan, but it happens. I mean, it's baseball, it happens. And they were able to string together some hits.” - Dan Wilson after his team’s loss against the Phillies in their game on Monday.

“He was really good, really good. That was his best start in a while.” - Rob Thomson after his team’s win against the Mariners in their game on Monday.

Randy Arozarena (R) LF

Cal Raleigh (S) C

Julio Rodríguez (R) CF

Eugenio Suárez (R) 3B

Josh Naylor (L) 1B

Mitch Garver (R) DH

Dominic Canzone (L) RF

J.P. Crawford (L) SS

Cole Young (L) 2B

Trea Turner (R) SS

Kyle Schwarber (L) DH

Bryce Harper (L) 1B

J.T. Realmuto (R) C

Alec Bohm (R) 3B

Brandon Marsh (L) CF

Nick Castellanos (R) RF

Max Kepler (L) LF

Bryson Stott (L) 2B

Batting Average:  Dominic Canzone (.289)

Hits:  Julio Rodríguez (135)

Home Runs:  Cal Raleigh (47)

RBI:  Cal Raleigh (102)

Stolen Bases:  Randy Arozarena (24)

Wins:  Bryan Woo (10)

Saves:  Andrés Muñoz (29)

ERA:  Sauryn Lao (0.00)

Batting Average:  Trea Turner (.295)

Hits:  Trea Turner (151)

Home Runs:  Kyle Schwarber (43)

RBI:  Kyle Schwarber (103)

Stolen Bases:  Trea Turner (28)

Wins:  Cristopher Sánchez (11)

Saves:  Jordan Romano (8)

ERA:  Jhoan Duran (0.00)

Managers:

Seattle Mariners: Dan Wilson (2nd season)

Philadelphia Phillies: Rob Thomson (4th season)