Seattle Mariners vs Houston Astros Prediction, Preview and Odds - 09/19/2025

Game Time: 8:10 pm ET, Friday, September 19, 2025

Venue:  Daikin Park, Houston, TX

Where to Watch:  ROOT Sports NW, SCHN

DraftKings:  Moneyline odds:  Mariners -108, Astros -112; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Mariners -105, Astros -115; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Mariners -105, Astros -115; Over/Under:  7.5 runs

Seattle Mariners:  83-69 (2nd place, AL West)

Houston Astros:  84-69 (1st place, AL West)

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Seattle Mariners:  9-1 last 10

Houston Astros:  6-4 last 10

The Mariners completed the sweep in their 4-game series against the Los Angeles Angels 4-0. They enter this game with an 83-69 record overall and have a road record of 35-42. This is the series opener of a 3-game series with the Astros on Friday with the series finale of their series against the Kansas City Royals still to be played on Thursday. The Mariners won the series opener on Tuesday and lost the 2nd game on Wednesday. Their offense ranks 11th in the MLB with a .739 OPS. Luis Castillo is their starting pitcher on Thursday while Bryan Woo is making his start in this game on Friday. He is 14-7 with a 3.02 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 1 HR, and 1 BB with 13 SO on 3 hits through 6 IP against the Los Angeles Angels.

The Astros are entering this series off a win and completed the sweep in their 3-game series against the Texas Rangers 3-0 in their last series. They enter this game with an 84-69 record overall and have a home record of 46-32. This is the 1st game of a 3-game series with the Mariners on Friday and they have Thursday off as a day of rest. Their offense ranks 13th in the MLB with a .718 OPS. Cristian Javier was their starting pitcher on Wednesday while Hunter Brown is making his start in this game on Friday. He is 12-7 with a 2.27 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 1 walk with 2 strikeouts on 4 hits through 6.2 innings pitched against the Atlanta Braves.

The current betting odds have the Astros listed as a slight favorite in this game according to Draftkings Sportsbook. The Astros have looked great in their games this season with their 84-69 record overall which has them right at the top of the AL West. They have also looked great in their own ballpark this year with their 46-32 home record. Meanwhile, the Mariners have looked really good in their games this season with their 83-69 record overall which has them right near the top of the AL West and in the division race. They haven't been a good road team though with their 35-42 road record this season. The Mariners have been red hot lately, going 9-1 in their last 10 games, but the Astros are also 6-4 in their last 10 and this is a big series for them to keep their lead in the division. They just swept the Rangers in their last series so they are going to bring their best effort here, and they have one of their best starters going in this one too. Brown is on the mound for the Mariners in this one and he has looked great this season. He is 12-7 with a 2.27 ERA and hasn't been giving up many runs lately. He is coming off another good start in which he gave up 2 earned runs and the team has won 2 games in a row now with him starting too. The Mariners are going with Woo in this one and he has looked good this season. He is 14-7 with a 3.02 ERA and hasn't been giving up many runs lately either. He gave up 2 earned runs in his last start and his team has also won 2 games in a row now with him starting, but he has struggled more in road starts this year and the Astros can take advantage of that at home where they have been so much better this season. The Astros also have the better bullpen which will be a big factor here. The best way to place a bet here is on the Astros to win this game. 

Mariners Astros Prediction:  Our MLB Pick for Friday, September 19, 2025 (8:10 pm ET start time) is Astros 3 Mariners 2.

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Seattle Mariners: 256-220 (-8.9 units) on the moneyline in all games. 114-125 (-20.4 units) on the moneyline in road games. 181-160 (-11.9 units) on the moneyline against right-handed starters. 21-13 OVER as a road underdog of +100 or higher.

Houston Astros: 115-104 (+6.8 units) on the moneyline when the money line is +125 to -125. 139-114 (+14.8 units) on the moneyline when playing against a team with a winning record. 184-148 (+15.2 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 23-14 OVER at home when the money line is +125 to -125. 

Seattle Mariners:  J. Kowar (RP) Fifteen Day IL - Shoulder. T. Thornton (RP) Sixty Day IL - Achilles. L. Evans (SP) Fifteen Day IL - Elbow. G. Santos (RP) Sixty Day IL - Knee. R. Bliss (2B) Sixty Day IL - Biceps.

Houston Astros:  Y. Alvarez (LF) Day To Day - Ankle. L. McCullers Jr. (SP) Fifteen Day IL - Hand. L. Garcia (SP) Sixty Day IL - Elbow. K. Ort (RP) Fifteen Day IL - Elbow. S. Arrighetti (SP) Fifteen Day IL - Elbow. J. Rooney (SP) Sixty Day IL - Concussion / Nasal. B. Sousa (RP) Fifteen Day IL - Elbow. B. Walter (RP) Sixty Day IL - Elbow. J. Hader (RP) Fifteen Day IL - Shoulder. I. Paredes (3B) Sixty Day IL - Hamstring. B. Rodgers (2B) Sixty Day IL - Oblique. Z. Dezenzo (RF) Sixty Day IL - Hand. P. Leon (RF) Sixty Day IL - Knee. R. Blanco (SP) Sixty Day IL - Elbow. H. Wesneski (RP) Sixty Day IL - Elbow.

“That’s how we wanted it to roll. The home run from J.P. was huge to give us the lead there. You’re looking at Brash and then [Andrés Muñoz], but sometimes it doesn’t go that way. And tonight it didn’t, but tomorrow we come back and go after it.” - Dan Wilson after his team’s loss against the Royals in their game on Wednesday.

“I think these guys know exactly what’s at stake. We played extremely well. Offensively, I thought the first inning was the key for our night. Having deGrom throw 30-plus pitches -- the first two guys get on and he strikes out Altuve and [Christian] Walker and you might see the end of that threat, but then Diaz [with] a big knock. I thought we carried that momentum, we made him work and we got some big hits.” - Joe Espada after his team’s win against the Rangers in their game on Wednesday.

Randy Arozarena (R) LF

Cal Raleigh (S) C

Julio Rodríguez (R) CF

Josh Naylor (L) 1B

Jorge Polanco (S) DH

Eugenio Suárez (R) 3B

Dominic Canzone (L) RF

Leo Rivas (S) 2B

J.P. Crawford (L) SS

Jeremy Peña (R) SS

Carlos Correa (R) 3B

Jose Altuve (R) 2B

Christian Walker (R) 1B

Victor Caratini (S) DH

Yainer Diaz (R) C

Jesús Sánchez (L) LF

Jake Meyers (R) CF

Zach Cole (L) RF

Batting Average:  Dominic Canzone (.301)

Hits:  Julio Rodríguez (168)

Home Runs:  Cal Raleigh (56)

RBI:  Cal Raleigh (118)

Stolen Bases:  Randy Arozarena (28)

Wins:  Bryan Woo (14)

Saves:  Andrés Muñoz (35)

ERA:  Jhonathan Díaz (0.00)

Batting Average:  Zach Cole (.333)

Hits:  Jose Altuve (148)

Home Runs:  Jose Altuve (26)

RBI:  Christian Walker (82)

Stolen Bases:  Jeremy Peña (20)

Wins:  Framber Valdez (12)

Saves:  Josh Hader (28)

ERA:  Jayden Murray (0.00)

Managers:

Seattle Mariners: Dan Wilson (2nd season)

Houston Astros: Joe Espada (2nd season)