San Francisco Giants vs San Diego Padres Prediction, Preview and Odds - 08/20/2025

Game Time: 9:40 pm ET, Wednesday, August 20, 2025

Venue:  Petco Park, San Diego, CA

Where to Watch:  MLB Network

DraftKings:  Moneyline odds:  Giants +128, Padres -157; Over/Under:  8 runs

Bet365:  Moneyline odds:  Giants +130, Padres -155; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Giants +130, Padres -155; Over/Under:  8 runs

San Francisco Giants:  61-64 (3rd place, NL West)

San Diego Padres:  69-56 (2nd place, NL West)

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San Francisco Giants:  3-7 last 10

San Diego Padres:  5-5 last 10

The Giants are entering this series off a win and lost their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 61-64 record overall and have a road record of 31-31. This is the 3rd game of a 4-game series with the Padres on Wednesday with the 2nd game still to be played on Tuesday. The Giants won the series opener on Monday. Their offense ranks 26th in the MLB with a .685 OPS. Kai-Wei Teng is their starting pitcher on Tuesday while Landen Roupp is making his start in this game on Wednesday. He is 7-6 with a 3.45 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 1 HR, and 1 BB with 5 SO on 5 hits through 3 IP against the Tampa Bay Rays.

The Padres are entering this series off a loss and got swept in their 3-game series against the Los Angeles Dodgers 3-0 in their last series. They enter this game with a 69-56 record overall and have a home record of 38-21. This is the 3rd game of a 4-game series with the Giants on Wednesday with the 2nd game of this series still to be played on Tuesday. The Padres lost the 1st game of this series on Monday. Their offense ranks 22nd in the MLB with a .704 OPS. Nick Pivetta is their starting pitcher on Tuesday while JP Sears is making his start in this game on Wednesday. He is 7-10 with a 5.12 ERA this season. His team lost their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 5 earned runs, 1 homer, and 1 walk with 4 strikeouts on 10 hits through 5 innings pitched against the Arizona Diamondbacks.

The current betting odds have the Padres listed as a favorite in this game according to Draftkings Sportsbook. The Padres have looked really good in their games this season with their 69-56 record overall which has them right near the top of the NL West. They have looked great in their own ballpark too with their 38-21 home record this season. Meanwhile, the Giants haven't looked great in their games this season with their 61-64 record overall which has them right in the middle of the NL West. They haven't been a great road team either with their 31-31 road record. The Giants haven't looked great lately either as they are 3-7 in their last 10 games while the Padres are 5-5 and have looked a lot better at home all season. The Giants are going to have Roupp on the mound in this one and he has looked good this season. He is 7-6 with a 3.45 ERA, but lately he has been giving up more runs. He is coming off a bad start in which he gave up 5 earned runs, giving up more runs in his starts lately, and the team has lost 2 of their last 3 games with him starting too. The Padres don't have a great starter on the mound themselves, but their pitching has been a lot better than the Giants this year as a whole and that is going to give them the edge in this ballpark where they have been so good this year. The best way to place a bet here is on the Padres to win this game. 

Giants Padres Prediction:  Our MLB Pick for Wednesday, August 20, 2025 (9:40 pm ET start time) is Padres 4 Giants 3.

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San Francisco Giants: 221-228 (-34.8 units) on the moneyline in all games. 104-119 (-10.6 units) on the moneyline in road games. 60-65 (-15 units) on the moneyline against left-handed starters. 37-29 UNDER in August games.

San Diego Padres: 43-26 (+4.1 units) on the moneyline vs. a starting pitcher whose lasts less than 5 innings per start. 89-58 (+11.6 units) on the moneyline vs. an NL team with a slugging percentage of .400 or worse on the season. 39-32 (+6 units) on the moneyline vs. a team with a good bullpen whose ERA is 3.45 or better. 52-29 UNDER vs. a starting pitcher whose gives up 0.5 or less HR's/start.

San Francisco Giants:  M. Chapman (3B) Ten Day IL - Hand. J. Encarnacion (RF) Ten Day IL - Hamstring. E. Miller (RP) Fifteen Day IL - Elbow. T. Murphy (C) Sixty Day IL - Back.

San Diego Padres:  J. Merrill (CF) Day To Day - Undisclosed. M. King (SP) Fifteen Day IL - Knee. J. Brito (RP) Sixty Day IL - Forearm. J. Musgrove (SP) Sixty Day IL - Elbow.

“You don’t see that call often, but I think it was the right one.” - Bob Melvin after his team’s win against the Giants in their game on Monday. 

“Ryan’s done a nice job, and he is a great option off the bench. It’s always going to be flexible. It’s going to be relative to the total picture of who we have on the club that day. Like every day, it’s always a question of who’s going to give us the best opportunity.” - Mike Shildt before his team’s loss against the Giants in their game on Monday.

Heliot Ramos (R) LF

Rafael Devers (L) 1B

Willy Adames (R) SS

Casey Schmitt (R) 3B

Wilmer Flores (R) DH

Jung Hoo Lee (L) CF

Christian Koss (R) 2B

Tyler Fitzgerald (R) RF

Patrick Bailey (S) C

Fernando Tatis Jr. (R) RF

Luis Arraez (L) 1B

Manny Machado (R) DH

Ramón Laureano (R) LF

Xander Bogaerts (R) SS

Jose Iglesias (R) 3B

Freddy Fermin (R) C

Jake Cronenworth (L) 2B

Bryce Johnson (S) CF

Batting Average:  Dominic Smith (.281)

Hits:  Heliot Ramos (128)

Home Runs:  Willy Adames (19)

RBI:  Wilmer Flores (63)

Stolen Bases:  Jung Hoo Lee (10)

Wins:  Logan Webb (11)

Saves:  Camilo Doval (15)

ERA:  Keaton Winn (0.00)

Batting Average:  Freddy Fermin (.318)

Hits:  Luis Arraez (141)

Home Runs:  Manny Machado (20)

RBI:  Manny Machado (72)

Stolen Bases:  Fernando Tatis (24)

Wins:  Nick Pivetta (12)

Saves:  Robert Suarez (33)

ERA:  Bradgley Rodriguez (0.00)

Managers:

San Francisco Giants: Bob Melvin (2nd season)

San Diego Padres: Mike Shildt (2nd season)