San Francisco Giants vs San Diego Padres Prediction, Preview and Odds - 08/19/2025

Game Time: 9:40 pm ET, Tuesday, August 19, 2025

Venue:  Petco Park, San Diego, CA

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Giants +193, Padres -241; Over/Under:  8 runs

Bet365:  Moneyline odds:  Giants +195, Padres -240; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Giants +195, Padres -240; Over/Under:  8 runs

San Francisco Giants:  60-64 (3rd place, NL West)

San Diego Padres:  69-55 (2nd place, NL West)

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San Francisco Giants:  3-7 last 10

San Diego Padres:  6-4 last 10

The Giants are entering this series off a win and lost their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 60-64 record overall and have a road record of 30-31. This is the 2nd game of a 4-game series with the Padres on Tuesday with the series opener still to be played on Monday. Their offense ranks 26th in the MLB with a .683 OPS. Robbie Ray is their starting pitcher on Monday while Kai-Wei Teng is making his start in this game on Tuesday. He is 1-2 with a 9.90 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 6 ER, 0 HR, and 4 BB with 0 SO on 4 hits through 1.2 IP against the San Diego Padres.

The Padres are entering this series off a loss and got swept in their 3-game series against the Los Angeles Dodgers 3-0 in their last series. They enter this game with a 69-55 record overall and have a home record of 38-20. This is the 2nd game of a 4-game series with the Giants on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 20th in the MLB with a .705 OPS. Nestor Cortes is their starting pitcher on Monday while Nick Pivetta is making his start in this game on Tuesday. He is 12-4 with a 2.87 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 5 strikeouts on 4 hits through 6.2 innings pitched against the San Francisco Giants.

The current betting odds have the Padres listed as a big favorite in this game according to Draftkings Sportsbook. The Padres have looked really good in their games this season with their 69-55 record overall which has them right near the top of the NL West. They have looked great in their own ballpark too with their 38-20 home record this season. Meanwhile, The Giants haven't looked great in their games this season with their 60-64 record overall which has them right in the middle of the NL West. They haven't been a great road team either with their 30-31 road record. The Giants have also been in a big slump lately as they are 3-7 in their last 10 games while the Padres are 6-4 and have been rolling. The Padres did just get swept by the Dodgers in their last series, but they will be looking to bounce back at home and do have the better pitching matchup in this one. Pivetta is on the mound for the Padres in this one and he has looked great this year. He is 12-4 with a 2.87 ERA this season and he has been their ace this season. He is coming off another good start in which he gave up 1 earned run and the team has won 2 of their last 3 games with him starting, having a lot of success with him all season too. The Giants are going with Teng in this one and he hasn't looked great this season. He is 1-2 with a 9.90 ERA and coming off a terrible start against the Padres last week. He gave up 6 earned runs and didn't even make it 2 innings in that game. He isn't going to be any better on the road here either, and the team has also lost 2 of their last 3 games with him making an appearance anyway. The best way to place a bet here is on the Padres to win this game and on the runline. 

Giants Padres Prediction:  Our MLB Pick for Tuesday, August 19, 2025 (9:40 pm ET start time) is Padres 7 Giants 1.

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San Francisco Giants: 220-228 (-36 units) on the moneyline in all games. 103-119 (-11.8 units) on the moneyline in road games. 161-163 (-19.7 units) on the moneyline against right-handed starters. 14-5 UNDER vs. a starting pitcher whose winning percentage is better than 70%.

San Diego Padres: 37-17 (+4.1 units) on the moneyline as a home favorite of -175 to -250. 89-57 (+12.6 units) on the moneyline vs. an NL team with a slugging percentage of .400 or worse on the season. 39-31 (+7.4 units) on the moneyline vs. a team with a good bullpen whose ERA is 3.45 or better. 41-29 UNDER vs. a team with a good bullpen whose ERA is 3.45 or better.

San Francisco Giants:  M. Chapman (3B) Ten Day IL - Hand. J. Encarnacion (RF) Ten Day IL - Hamstring. E. Miller (RP) Fifteen Day IL - Elbow. T. Murphy (C) Sixty Day IL - Back.

San Diego Padres:  J. Merrill (CF) Day To Day - Undisclosed. M. King (SP) Fifteen Day IL - Knee. J. Brito (RP) Sixty Day IL - Forearm. J. Musgrove (SP) Sixty Day IL - Elbow.

“I thought he just went down. I was worried that he may have hurt something like his ankle. I wasn’t really sure because he was down for a while. The replay took a while, but our people were talking about it and realized he caught it between his knees. Pretty good. Haven’t seen that one before." - Bob Melvin after his team’s win against the Rays in their game on Sunday.

“The body of work says whatever the record’s been consistently. If you think we’re going to look at three games and get overly concerned about it? Are we disappointed? Absolutely. I won’t minimize that. But it just only strengthens our resolve. The confidence in our team, amongst this team within ourselves, is very strong.” - Mike Shildt after his team’s loss against the LA Dodgers in their game on Sunday.

Jung Hoo Lee (L) CF

Heliot Ramos (R) LF

Rafael Devers (L) DH

Willy Adames (R) SS

Dominic Smith (L) 1B

Christian Koss (R) 3B

Patrick Bailey (S) C

Drew Gilbert (L) RF

Tyler Fitzgerald (R) 2B

Fernando Tatis Jr. (R) RF

Luis Arraez (L) DH

Manny Machado (R) 3B

Jackson Merrill (L) CF

Xander Bogaerts (R) SS

Ryan O'Hearn (L) 1B

Ramón Laureano (R) LF

Jake Cronenworth (L) 2B

Freddy Fermin (R) C

Batting Average:  Christian Koss (.281)

Hits:  Heliot Ramos (126)

Home Runs:  Willy Adames (19)

RBI:  Willy Adames (62)

Stolen Bases:  Jung Hoo Lee (10)

Wins:  Logan Webb (11)

Saves:  Camilo Doval (15)

ERA:  Keaton Winn (0.00)

Batting Average:  Freddy Fermin (.350)

Hits:  Luis Arraez (140)

Home Runs:  Manny Machado (20)

RBI:  Manny Machado (72)

Stolen Bases:  Fernando Tatis (24)

Wins:  Nick Pivetta (12)

Saves:  Robert Suarez (33)

ERA:  Bradgley Rodriguez (0.00)

Managers:

San Francisco Giants: Bob Melvin (2nd season)

San Diego Padres: Mike Shildt (2nd season)