San Francisco Giants vs Milwaukee Brewers Prediction, Preview and Odds - 08/23/2025

Game Time: 7:10 pm ET, Saturday, August 23, 2025

Venue:  American Family Field, Milwaukee, WI

Where to Watch:  MLB.tv, NBCS-BA, FDSWI

DraftKings:  Moneyline odds:  Giants +112, Brewers -137; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Giants +110, Brewers -130; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Giants +115, Brewers -140; Over/Under:  7.5 runs

San Francisco Giants:  61-67 (4th place, NL West)

Milwaukee Brewers:  80-48 (1st place, NL Central)

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San Francisco Giants:  2-8 last 10

Milwaukee Brewers:  6-4 last 10

The Giants are entering this series off a loss and lost their 4-game series against the San Diego Padres 3-1 in their last series. They enter this game with a 61-67 record overall and have a road record of 31-34. This is the 2nd game of a 3-game series with the Brewers on Saturday with the series opener still to be played on Friday. Their offense ranks 26th in the MLB with a .683 OPS. Rookie pitcher Carson Whisenhunt is their starting pitcher on Friday while Logan Webb is making his start in this game on Saturday. He is 11-9 with a 3.19 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 0 BB with 7 SO on 3 hits through 7 IP against the Tampa Bay Rays.

The Brewers are entering this series off a win and lost their 5-game series against the Chicago Cubs 3-2 in their last series. They enter this game with a 80-48 record overall and have a home record of 42-20. This is the 2nd game of a 3-game series with the Giants on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 11th in the MLB with a .736 OPS. Jose Quintana is their starting pitcher on Friday while Freddy Peralta is making his start in this game on Saturday. He is 15-5 with a 2.78 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 3 walks with 6 strikeouts on 1 hit through 6 innings pitched against the Chicago Cubs.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 80-48 record overall which has them right at the top of the NL Central with the best record in the entire MLB. They have also looked great in their own ballpark this year with their 42-20 home record. Meanwhile, the Giants haven't looked good in their games this season with their 61-67 record overall which has them right near the bottom of the NL West. They haven't been a good road team either with their 31-34 road record this season. The Giants have also looked terrible lately as they are 2-8 in their last 10 games and have been in a huge slump. The Brewers have also been cooling off lately, but they are 6-4 in their last 10 games and will be looking to take advantage of a slumping Giants team at home. The Brewers are going with Peralta in this one and he has looked great this season. He is 15-5 with a 2.78 ERA and has been one of their best starters all year. He is coming off another great start in which he gave up no runs and the team has won 3 games in a row now with him starting too. The Giants are going with Webb in this one and he has also looked good this season. He is 11-9 with a 3.19 ERA and hasn't been giving up many runs lately. He gave up no runs in his last start and the team has won 2 of their last 3 games with him starting, but he does have 9 losses this year for a reason and the Giants have one of the worst offenses in the MLB too. The Brewers have the slightly better starter here at home along with the much stronger offense. The best way to place a bet here is on the Brewers to win this game. 

Giants Brewers Prediction:  Our MLB Pick for Saturday, August 23, 2025 (7:10 pm ET start time) is Brewers 3 Giants 0.

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San Francisco Giants: 221-231 (-37.8 units) on the moneyline in all games. 104-122 (-13.6 units) on the moneyline in road games. 99-109 (-12.3 units) on the moneyline when the money line is +125 to -125. 15-5 UNDER vs. a starting pitcher whose winning percentage is better than 70%.

Milwaukee Brewers: 266-192 (+54.3 units) on the moneyline in all games. 138-90 (+19.8 units) on the moneyline in home games. 135-88 (+21.4 units) on the moneyline when playing against a team with a losing record. 6-0 UNDER after 9 consecutive games versus division rivals.

San Francisco Giants:  L. Roupp (SP) Day To Day - Leg. M. Chapman (3B) Ten Day IL - Hand. J. Encarnacion (RF) Ten Day IL - Hamstring. E. Miller (RP) Sixty Day IL - Elbow. T. Murphy (C) Sixty Day IL - Back.

Milwaukee Brewers:  J. Ortiz (SS) Day To Day - Hamstring. D. Hall (RP) Fifteen Day IL - Oblique. L. Henderson (SP) Fifteen Day IL - Elbow. J. Chourio (CF) Ten Day IL - Hamstring. J. Montgomery (SP) Sixty Day IL - Elbow. J. Bauers (LF) Ten Day IL - Shoulder. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

“When he left spring, he was a guy that we felt like we might see. He was on the verge of making the team and got off to a little bit of a slow start. He’s pitching his best baseball right now." - Bob Melvin on Joel Peguero.

“I’m not even thinking about that, guys. I’m being honest. You can’t even let your head go there. What you think about is the health of your team, their mental health, their physical health, and move ahead. ‘Here we go. Who do we play tonight?’ If you think there’s another gear, that gear gets you into trouble. Then you’re tapping into your emotions, usually, and you’re trying harder. When you squeeze the egg too hard, what happens?” - Pat Murphy after his team’s win against the Cubs in their game on Thursday.

Jung Hoo Lee (L) CF

Heliot Ramos (R) LF

Rafael Devers (L) DH

Willy Adames (R) SS

Dominic Smith (L) 1B

Casey Schmitt (R) 3B

Christian Koss (R) 2B

Luis Matos (R) RF

Andrew Knizner (R) C

Sal Frelick (L) RF

Isaac Collins (S) LF

William Contreras (R) C

Christian Yelich (L) DH

Andrew Vaughn (R) 1B

Caleb Durbin (R) 3B

Brice Turang (L) 2B

Brandon Lockridge (R) CF

Joey Ortiz (R) SS

Batting Average:  Dominic Smith (.276)

Hits:  Heliot Ramos (129)

Home Runs:  Willy Adames (20)

RBI:  Wilmer Flores (63)

Stolen Bases:  Jung Hoo Lee (10)

Wins:  Logan Webb (11)

Saves:  Camilo Doval (15)

ERA:  Keaton Winn (0.00)

Batting Average:  Andrew Vaughn (.313)

Hits:  Brice Turang (132)

Home Runs:  Christian Yelich (26)

RBI:  Christian Yelich (87)

Stolen Bases:  Brice Turang (21)

Wins:  Freddy Peralta (15)

Saves:  Trevor Megill (30)

ERA:  Abner Uribe (1.76)

Managers:

San Francisco Giants: Bob Melvin (2nd season)

Milwaukee Brewers: Pat Murphy (2nd season)