San Francisco Giants vs Milwaukee Brewers Prediction, Preview and Odds - 08/22/2025

Game Time: 8:10 pm ET, Friday, August 22, 2025

Venue:  American Family Field, Milwaukee, WI

Where to Watch:  MLB.tv, NBCS-BA, FDSWI

DraftKings:  Moneyline odds:  Giants +140, Brewers -172; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Giants +140, Brewers -170; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Giants +140, Brewers -170; Over/Under:  8.5 runs

San Francisco Giants:  61-66 (4th place, NL West)

Milwaukee Brewers:  79-48 (1st place, NL Central)

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San Francisco Giants:  2-8 last 10

Milwaukee Brewers:  6-4 last 10

The Giants lost their 3-game series against the Tampa Bay Rays 2-1. They enter this game with a 61-66 record overall and have a road record of 31-33. This is the series opener of a 3-game series with the Brewers on Friday with the series finale of their series against the San Diego Padres still to be played on Thursday. The Giants won the series opener of that series on Monday, lost the 2nd game on Tuesday, and lost the 3rd game on Wednesday. Their offense ranks 26th in the MLB with a .682 OPS. Justin Verlander is their starting pitcher on Thursday while rookie pitcher Carson Whisenhunt is making his start in this game on Friday. He is 1-1 with a 5.02 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 3 HR, and 3 BB with 5 SO on 5 hits through 4 IP against the Washington Nationals.

The Brewers won their 3-game series against the Cincinnati Reds 2-1. They enter this game with a 79-48 record overall and have a home record of 42-20. This is the 1st game of a 3-game series with the Giants on Friday with the series finale of their series against the Chicago Cubs still to be played on Thursday. The Brewers won the 1st game of that series on Monday, lost the 2nd game on Tuesday, lost the 3rd game on Tuesday, and lost the 4th game on Wednesday. Their offense ranks 11th in the MLB with a .737 OPS. Quinn Priester is their starting pitcher on Thursday while Jose Quintana is making his start in this game on Friday. He is 10-4 with a 3.32 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 4 strikeouts on 5 hits through 6.1 innings pitched against the Cincinnati Reds.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 79-48 record overall which has them right at the top of the NL Central with the best record in the entire MLB. They have also looked great in their own ballpark this year with their 42-20 home record. Meanwhile, the Giants haven't looked good in their games this season with their 61-66 record overall which has them right near the bottom of the NL West. They haven't been a good road team either with their 31-33 road record this season. The Giants have also been in a terrible slump lately as they are 2-8 in their last 10 games while the Brewers are 6-4 in their last 10 and have still been really hot lately. The Brewers are going to have Quintana on the mound in this one and he has looked good this season. He is 10-4 with a 3.32 ERA and hasn't been giving up many runs all year. He is coming off another great start in which he gave up 1 earned run and the team has won 3 of their last 4 games with him starting too. The Giants are going with Carson Whisenhunt in this one and he hasn’t been great in his few starts. He is 1-1 with a 5.02 ERA and doesn’t have much experience pitching in the MLB. He is coming off a start in which he gave up 3 earned runs and the team has lost 2 of their last 3 games with him starting too. The Giants also have one of the worst offenses in the MLB so the Brewers have a big advantage here at home. The best way to place a bet here is on the Brewers to win this game. 

Giants Brewers Prediction:  Our MLB Pick for Friday, August 22, 2025 (8:10 pm ET start time) is Brewers 5 Giants 1.

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San Francisco Giants: 221-230 (-36.8 units) on the moneyline in all games. 104-121 (-12.6 units) on the moneyline in road games. 60-66 (-16 units) on the moneyline against left-handed starters. 15-5 UNDER vs. a starting pitcher whose winning percentage is better than 70%.

Milwaukee Brewers: 265-192 (+53 units) on the moneyline in all games. 138-90 (+19.8 units) on the moneyline in home games. 135-88 (+21.4 units) on the moneyline when playing against a team with a losing record. 5-0 UNDER after 9 consecutive games versus division rivals.

San Francisco Giants:  L. Roupp (SP) Day To Day - Leg. M. Chapman (3B) Ten Day IL - Hand. J. Encarnacion (RF) Ten Day IL - Hamstring. E. Miller (RP) Fifteen Day IL - Elbow. T. Murphy (C) Sixty Day IL - Back.

Milwaukee Brewers:  D. Hall (RP) Fifteen Day IL - Oblique. L. Henderson (SP) Fifteen Day IL - Elbow. J. Chourio (CF) Ten Day IL - Hamstring. J. Montgomery (SP) Sixty Day IL - Elbow. J. Bauers (LF) Ten Day IL - Shoulder. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

“The ball hit him in the back of the leg, I think. It was when he caught himself and then when he had to go get the ball again. I don’t know if he hyperextended it. Obviously, it was scary for a second.” - Bob Melvin on the injury to Landen Roupp after his team’s loss against the Padres in their game on Wednesday.

“We didn’t get the outcome we wanted, but we showed tremendous heart and tremendous relentlessness. I mean, Miz’s start, that’s not good enough. He lost his, whatever you want to call it, focus. That’s not good enough.” - Pat Murphy after his team’s loss against the Cubs in their game on Wednesday.

Heliot Ramos (R) LF

Rafael Devers (L) 1B

Willy Adames (R) SS

Wilmer Flores (R) DH

Casey Schmitt (R) 3B

Jung Hoo Lee (L) CF

Christian Koss (R) 2B

Tyler Fitzgerald (R) RF

Patrick Bailey (S) C

Sal Frelick (L) RF

Isaac Collins (S) LF

William Contreras (R) C

Christian Yelich (L) DH

Andrew Vaughn (R) 1B

Caleb Durbin (R) 3B

Brice Turang (L) 2B

Brandon Lockridge (R) CF

Joey Ortiz (R) SS

Batting Average:  Dominic Smith (.282)

Hits:  Heliot Ramos (129)

Home Runs:  Willy Adames (19)

RBI:  Wilmer Flores (63)

Stolen Bases:  Jung Hoo Lee (10)

Wins:  Logan Webb (11)

Saves:  Camilo Doval (15)

ERA:  Keaton Winn (0.00)

Batting Average:  Andrew Vaughn (.320)

Hits:  Brice Turang (130)

Home Runs:  Christian Yelich (26)

RBI:  Christian Yelich (87)

Stolen Bases:  Brice Turang (21)

Wins:  Freddy Peralta (15)

Saves:  Trevor Megill (29)

ERA:  Logan Henderson (1.78)

Managers:

San Francisco Giants: Bob Melvin (2nd season)

Milwaukee Brewers: Pat Murphy (2nd season)