San Francisco 49ers vs Tampa Bay Buccaneers Prediction, Preview and Odds - 10/12/2025

Game Time: 4:25 pm ET, Sunday, October 12, 2025

Venue:  Raymond James Stadium, Tampa, FL

Where to Watch:  CBS

DraftKings:  Point Spread:  49ers +3, Buccaneers -3; Over/Under:  47.5 points

Bet365:  Point Spread:  49ers +3, Buccaneers -3; Over/Under:  47.5 points

BetMGM:  Point Spread:  49ers +3, Buccaneers -3; Over/Under:  47.5 points

San Francisco 49ers:  4-1 (1st place, NFC West)

Tampa Bay Buccaneers:  4-1 (1st place, NFC South)

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San Francisco 49ers:  won their last game on the road against the Los Angeles Rams 26-23 in overtime.

Tampa Bay Buccaneers:  won their last game on the road against the Seattle Seahawks 38-35.

The 49ers are entering this game with a 4-1 record overall and they have a 3-0 record in their divisional games too. They are 1-1 in their home games, 3-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Los Angeles Rams 26-23 in OT. Mac Jones was the starting QB and he completed 33/49 passes for 342 passing yards, 2 touchdowns, and 0 interceptions. Christian McCaffrey led the team in rushing yards with 57. Kendrick Bourne led the receivers with 142 receiving yards on 10 receptions. Marques Sigle led the defense in that game with 7 solo tackles and 6 assisted tackles while Bryce Huff led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Buccaneers are entering this game with a 4-1 record overall and they have a 1-0 record in their divisional games too. They are 1-1 in their home games, 3-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Seattle Seahawks 38-35. Baker Mayfield was the starting QB and he completed 29/33 passes for 379 passing yards, 2 touchdowns, and 0 interceptions. Rachaad White led the team in rushing yards with 41 and 2 TDs. Emeka Egbuka led the receivers with 163 receiving yards on 7 receptions and 1 TD. Jacob Parrish and Lavonte David each led the defense in that game with 5 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. Lavonte David came away with the only interception for them in that one.

The current betting odds have the 49ers listed as a 3 point underdog in this game according to Draftkings Sportsbook. The 49ers have looked great in their games this season with their 4-1 record overall which has them right at the top of the NFC West. The injuries have been piling up again for this 49ers team, but unlike last season, they continue to find ways to win games while banged up. Their defense has still looked good in their games and the offense has looked better this season with Mac Jones at the helm. Meanwhile, the Buccaneers have looked great in their games this season with their 4-1 record overall which has them right at the top of the NFC South. They are off a 38-35 win on the road over the Seahawks and their offense has looked great this season, rolling over teams in some of their games, but this isn't a great situation for them. That was a big win for the Bucs on the road, but now they are coming back home with less time to prepare since the 49ers played last Thursday and have had a few extra days of rest. The Buccaneers have also been banged up all season, just like the 49ers, but the 49ers have the better head coach to deal with this situation. The Bucs are a really good team this year, but they have played in a lot of close games this season and this will likely be another game that gets decided by a field goal. The best way to place a bet here is on the 49ers to cover the spread in this game. 

49ers Buccaneers Prediction:  Our NFL Pick for Sunday, October 12, 2025 (4:25 pm ET start time) is 49ers 23 Buccaneers 20.

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San Francisco 49ers: 17-24 ATS in all games. 2-8 ATS after a game with a turnover margin of +2 or better. 3-11 ATS vs. good passing teams averaging 235 or more passing yards/game. 12-5 OVER when playing against a team with a winning record. 6-2 OVER off a win against a division rival.

Tampa Bay Buccaneers: 25-17 ATS in all games. 5-1 ATS after allowing 30 points or more last game. 8-4 ATS vs. good passing teams averaging 7 or more passing yards/att. 8-4 OVER after scoring 30 points or more last game. 8-4 OVER vs. good passing teams averaging 7 or more passing yards/att.

San Francisco 49ers:  J. Jennings (WR) Injured - Ankle. C. McCaffrey (RB) Injured - Rest. J. Watkins (WR) Injured - Calf. T. Williams (OT) Injured - Rest. K. Davis (DL) Injured - Hand. K. Givens (DL) Injured - Pectoral. C. West (DL) Injured - Thumb. K. Bourne (WR) Injured - Rib. T. Morstead (P) Injured - Back. M. Mustapha (S) Injured - Knee. M. Williams (DL) Injured - Wrist. R. Pearsall (WR) Injured - Knee. B. Purdy (QB) Injured - Toe. M. Jones (QB) Injured - Knee. U. Stout (CB) Injured - Ankle. R. Beal Jr. (DL) Injured - Ankle. A. Collins (DL) Injured - Knee. Y. Gross-Matos (DL) Injured - Knee.

Tampa Bay Buccaneers:  T. Bridgewater (QB) Injured - Shoulder. L. David (LB) Injured - Knee. J. Dean (CB) Injured - Hip. T. Wirfs (OT) Injured - Knee. M. Evans (WR) Injured - Hamstring. C. Godwin Jr. (WR) Injured - Shin. B. Irving (RB) Injured - Foot. Z. McCollum (CB) Injured - Thumb. B. Morrison (CB) Injured - Hamstring. C. Izien (S) Injured - Quad.

“They were unbelievable. We talked about how long this game was going to be, how focused we had to be, how competitive we had to be for the entire time. Started out great, but it’s a good team. They tightened it up. Got real tight, then lost a number of dudes. We had to overcome losing two D-linemen in that game, and the D-line is still stepping it up big. That was a huge character win.” - Kyle Shanahan after his team’s win against the LA Rams in their last game. 

“He was sharp. Baker doesn’t try to have two subpar games in a row. He was still (ticked) from last week.” - Todd Bowles after his team’s win against the Seahawks in their last game. 

WR Bourne, Kendrick

WR Robinson, Demarcus

WR Valdes-Scantling, Marquez

TE Tonges, Jake

QB Jones, Mac

RB McCaffrey, Christian

FB Juszczyk, Kyle

WR Shepard, Sterling

WR Egbuka, Emeka

WR Johnson, Tez

TE Otton, Cade

QB Mayfield, Baker

RB White, Rachaad

Passing: Mac Jones (905)

Rushing: Christian McCaffrey (282)

Receiving: Christian McCaffrey (387)

Touchdowns: Christian McCaffrey (3)

Passing: Baker Mayfield (1,283)

Rushing: Bucky Irving (237)

Receiving: Emeka Egbuka (445)

Touchdowns: Emeka Egbuka (5)

Coaches:

San Francisco 49ers: Kyle Shanahan (9th season)

Tampa Bay Buccaneers: Todd Bowles (4th season)