by Rod Pearson
Friday, Oct 09, 2026
Game Time: 4:25 pm ET, Sunday, October 11, 2026
Venue: Lumen Field, Seattle, WA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: 49ers +3, Seahawks -3; Over/Under: 45.5 points
Bet365: Point Spread: 49ers +3, Seahawks -3; Over/Under: 46.5 points
BetMGM: Point Spread: 49ers +3, Seahawks -3; Over/Under: 46.5 points
Season Record
San Francisco 49ers: 4-0 (1st place, NFC West)
Seattle Seahawks: 3-1 (2nd place, NFC West)
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San Francisco 49ers: won their last game at home against the Denver Broncos 24-14.
Seattle Seahawks: won their last game at home against the Los Angeles Chargers 30-23.
San Francisco 49ers vs Seattle Seahawks Preview and Analysis
The 49ers are entering this game with a 4-0 record overall and they have a 2-0 record in their divisional games too. They are 3-0 in their home games, 0-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Denver Broncos 24-14. Brock Purdy was the starting QB and he completed 19/30 passes for 218 passing yards, 2 touchdowns, and 0 interceptions. Christian McCaffrey led the team in rushing yards with 52 and 1 TD. Mike Evans led the receivers with 76 receiving yards on 5 receptions. Dre Greenlaw led the defense in that game with 12 solo tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.
The Seahawks are entering this game with a 3-1 record overall and they have a 1-0 record in their divisional games too. They are 2-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Los Angeles Chargers 30-23. Sam Darnold was the starting QB and he completed 13/22 passes for 168 passing yards, 2 touchdowns, and 1 interception. Emanuel Wilson led the team in rushing yards with 81 and 1 TD. Jaxon Smith-Njigba led the receivers with 76 receiving yards on 5 receptions. Ernest Jones IV led the defense in that game with 12 solo tackles while Ernest Jones IV, Nick Emmanwori, Uchenna Nwosu, and Byron Murphy II each led the defense in sacks with 1. Ernest Jones IV and Drake Thomas each came away with 1 interception for them in that one.
49ers vs Seahawks Prediction
The current betting odds have the Seahawks listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Seahawks have looked good in their games this season with their 3-1 record overall which has them right near the top of the NFC West. They have looked great on their home field too with their 2-0 home record this season. Meanwhile, the 49ers have looked great in their games this season with their 4-0 record overall which has them right at the top of the NFC West. They haven't played any road games yet and will be playing their first road game of the season. The 49ers are one of the few undefeated teams left this season and they have been rolling over teams in their games. They opened the season in Australia with a big statement win over the Rams and now they are coming off a 24-14 win over the Broncos. They haven't actually played a true road game though and this is going to be no easy task against the Super Bowl champions with one of the best defenses in the NFL. The Seahawks are coming off a 30-23 win over the Chargers in their last one and their offense has looked a lot better lately, putting up a ton of points in their last 3 games. Their defense also crushed the 49ers in their last 2 meetings and the 49ers haven't really changed much to fix that issue. The Seahawks already took a bad loss to the Commanders too, but a win in this game would put them tied with the 49ers for the top of the division again, so look for the Seahawks to bring their best effort here and assert their dominance as the team to beat in this division. The best way to place a bet here is on the Seahawks to cover the spread in this game.
49ers Seahawks Prediction: Our NFL Pick for Sunday, October 11, 2026 (4:25 pm ET start time) is Seahawks 27 49ers 20.
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NFL Betting Trends
San Francisco 49ers: 1-6 ATS as a road underdog of 7 points or less. 5-10 ATS versus division opponents. 1-8 ATS vs. good teams - outscoring opponents by 6+ PPG on the season. 11-4 OVER in a road game where the total is between 42.5 and 49 points. 9-4 OVER vs. good offensive teams - scoring 24 or more points/game.
Seattle Seahawks: 11-5 ATS in games where the line is +3 to -3. 9-4 ATS after scoring 30 points or more last game. 10-4 ATS versus division opponents. 10-2 OVER as a home favorite of 7 points or less. 18-11 OVER in games played on turf.
Key Injuries
San Francisco 49ers: K. Juszczyk (FB) Injured - Knee. T. Williams (OT) Injured - Rest. C. McCaffrey (RB) Injured - Rest. M. Evans (WR) Injured - Ribs. D. Greenlaw (LB) Injured - Rest. N. Bosa (DL) Injured - Knee. M. Sigle (S) Injured - Ankle. U. Stout (CB) Injured - Shoulder. M. Williams (DL) Injured - Knee. R. Height (DL) Injured - Hand. K. Black (RB) Injured - Illness. J. Dugger (LB) Injured - Shoulder. J. Thompson Jr. (DL) Injured - Ankle.
Seattle Seahawks: E. Jones IV (LB) Injured - Rest. J. Neal (CB) Injured - Hamstring. L. Williams (DL) Injured - Ankle. C. Surratt (LB) Injured - Calf. I. Charles (WR) Injured - Knee. Z. Charbonnet (RB) Injured - Knee. J. Smith-Njigba (WR) Injured - Rest. P. O'Connell (LB) Injured - Thumb. T. Okada (S) Injured - Hamstring. N. Pritchett (CB) Injured - Ankle. G. Holani (RB) Injured - Ribs. T. Knight (LB) Injured - Ankle. B. Stephens (OG) Injured - Knee.
Notable Quotes
“We wanted to break through whatever that was and just be ourselves. I'm glad we could get some momentum going in the second half. That's why it's a four-quarter game.” - Brock Purdy after their win against the Broncos in their last game.
“We're really grateful for where we're at right now and excited to move forward. But we also understand that we have definitely a lot of room for improvement with our operation, how we take care of the football and obviously the penalties are something we need to address.” - Mike Macdonald after his team’s win against the LA Chargers in their last game.
Starting Lineups
San Francisco 49ers
WR Evans, Mike
WR Cowing, Jacob
WR Samuel Sr, Deebo
TE Kittle, George
QB Purdy, Brock
RB McCaffrey, Christian
FB Juszczyk, Kyle
Seattle Seahawks
WR Smith-Njigba, Jaxon
WR Shaheed, Rashid
WR Kupp, Cooper
TE Barner, AJ
QB Darnold, Sam
RB Wilson, Emanuel
FB Russell, Brady
Statistical Leaders
San Francisco 49ers
Passing: Brock Purdy (1,007)
Rushing: Christian McCaffrey (218)
Receiving: George Kittle (244)
Touchdowns: Christian McCaffrey (4)
Seattle Seahawks
Passing: Sam Darnold (560)
Rushing: Emanuel Wilson (190)
Receiving: Jaxon Smith-Njigba (481)
Touchdowns: Jaxon Smith-Njigba (6)
Coaches:
San Francisco 49ers: Kyle Shanahan (10th season)
Seattle Seahawks: Mike Macdonald (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
