by Rod Pearson
Tuesday, Jan 13, 2026
Game Time: 8:00 pm ET, Saturday, January 17, 2026
Venue: Lumen Field, Seattle, WA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: 49ers +7.5, Seahawks -7.5; Over/Under: 45.5 points
Bet365: Point Spread: 49ers +7.5, Seahawks -7.5; Over/Under: 45.5 points
BetMGM: Point Spread: 49ers +7.5, Seahawks -7.5; Over/Under: 45.5 points
Season Record
San Francisco 49ers: 12-5 (3rd place, NFC West)
Seattle Seahawks: 14-3 (1st place, NFC West)
Do not miss out on our expert handicapper analysis! ASA, Inc. is on a HOT STREAK in the NFL on a 15-8-1 NFL RUN for +$6,300 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
San Francisco 49ers: won their last game on the road against the Philadelphia Eagles 23-19.
Seattle Seahawks: won their last game on the road against the San Francisco 49ers 13-3.
San Francisco 49ers vs Seattle Seahawks Preview and Analysis
The 49ers are entering this game with a 12-5 record overall and they have a 4-2 record in their divisional games too. They are 5-3 in their home games, 7-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Philadelphia Eagles 23-19. Brock Purdy was the starting QB and he completed 18/31 passes for 262 passing yards, 2 touchdowns, and 2 interceptions. Christian McCaffrey led the team in rushing yards with 48. Demarcus Robinson led the receivers with 111 receiving yards on 6 receptions and 1 TD. Eric Kendricks led the defense in that game with 7 solo tackles and 3 assisted tackles while Keion White led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Seahawks are entering this game with a 14-3 record overall and they have a 4-2 record in their divisional games too. They are 6-2 in their home games, 8-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the San Francisco 49ers 13-3. Sam Darnold was the starting QB and he completed 20/26 passes for 198 passing yards, 0 touchdowns, and 0 interceptions. Kenneth Walker III led the team in rushing yards with 97. Jaxon Smith-Njigba led the receivers with 84 receiving yards on 6 receptions. Nick Emmanwori led the defense in that game with 4 solo tackles and 3 assisted tackles while Jarran Reed, Derick Hall, and Uchenna Nwosu each led the defense in sacks with 1. Drake Thomas came away with the only interception for them in that one.
49ers vs Seahawks Prediction
The current betting odds have the Seahawks listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. The Seahawks have looked great in their games this season with their 14-3 record overall which had them right at the top of the NFC West with the best record in the entire NFL. They have looked really good on their home field too with their 6-2 home record this year. Meanwhile, the 49ers have looked really good in their games this season with their 12-5 record overall, but that record had them right near the bottom of the NFC West in a competitive division. They have been a great road team with their 7-2 road record this season too. The 49ers are off a 23-19 win over the Eagles in their last one, going on the road and kicking out the defending Super Bowl champions, but the Eagles looked like a team with a lot of issues coming into the playoffs. The 49ers had their chance to get the number 1 seed in the NFC in week 18 at home and they blew it with a 13-3 loss to the Seahawks. The Seahawks have been rolling in their games lately with one of the best defenses in the NFL, and they have rest on their side with the bye week in the Wild Card Round. They are off that 13-3 win over the 49ers in their last one, but their defense was all over the 49ers in that game. The Seahawks offense wasn't great and it hasn't looked great at times, but this is a terrible 49ers defense that has been giving up a ton of points lately. The Seahawks will have a better offensive output against the 49ers at home in this game, and that 49ers offense couldn't do anything against the Seahawks defense just 2 weeks ago. Look for the Seahawks to shut this 49ers offense down again and set their own offense up in favorable positions. The best way to place a bet here is on the Seahawks to cover the spread in this game.
49ers Seahawks Prediction: Our NFL Pick for Saturday, January 17, 2026 (8:00 pm ET start time) is Seahawks 24 49ers 10.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this San Francisco 49ers Seattle Seahawks prediction, be sure to drop by every day for our weekly NFL predictions and previews.
NFL Betting Trends
San Francisco 49ers: 3-8 ATS as an underdog. 1-8 ATS after a win by 6 or less points. 2-8 ATS vs. good teams - outscoring opponents by 6+ PPG on the season. 14-7 OVER in a road game where the total is between 42.5 and 49 points. 13-5 OVER vs. good offensive teams - scoring 24 or more points/game.
Seattle Seahawks: 21-14 ATS against conference opponents. 10-5 ATS after playing a division game. 17-10 ATS after 1 or more consecutive wins. 11-5 OVER as a favorite of 3.5 to 9.5 points. 6-2 OVER after scoring 14 points or less last game.
Key Injuries
San Francisco 49ers: R. Green (CB) Questionable - Ankle. T. Williams (OT) Questionable - Hamstring. C. McCaffrey (RB) Injured - NIR-Rest. G. Kittle (TE) Injured - Ankle. K. Davis (DL) Injured - Knee. J. Elliott (DL) Injured - Knee. L. Gifford (LB) Questionable - Quadricep. Y. Gross-Matos (DL) Injured - Knee. K. White (DL) Questionable - Groin. D. Winters (LB) Questionable - Ankle. J. Brown (S) Injured - Rib. J. Cowing (WR) Questionable - Hamstring. R. Pearsall (WR) Questionable - Knee.
Seattle Seahawks: None.
Notable Quotes
“It’s just cool for everybody across the board to be able to have this kind of win and celebrate all the stuff that we’ve been through.” - Brock Purdy after their win against the Eagles in the Wild Card Round.
“I love how we started the game. Felt like we really set the tone.” - Mike Macdonald after his team’s win against the 49ers in their regular season finale.
Starting Lineups
San Francisco 49ers
WR Bourne, Kendrick
WR Jennings, Jauan
WR Robinson, Demarcus
TE Tonges, Jake
QB Purdy, Brock
RB McCaffrey, Christian
FB Juszczyk, Kyle
Seattle Seahawks
WR Smith-Njigba, Jaxon
WR Shaheed, Rashid
WR Kupp, Cooper
TE Barner, AJ
QB Darnold, Sam
RB Walker III, Kenneth
FB Ouzts, Robbie
Statistical Leaders
San Francisco 49ers
Passing: Brock Purdy (2,167)
Rushing: Christian McCaffrey (1,202)
Receiving: Christian McCaffrey (924)
Touchdowns: Christian McCaffrey (17)
Seattle Seahawks
Passing: Sam Darnold (4,048)
Rushing: Kenneth Walker III (1,027)
Receiving: Jaxon Smith-Njigba (1,793)
Touchdowns: Zach Charbonnet (12)
Coaches:
San Francisco 49ers: Kyle Shanahan (9th season)
Seattle Seahawks: Mike Macdonald (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
