San Francisco 49ers vs New Orleans Saints Prediction, Preview and Odds - 09/14/2025

Game Time: 1:00 pm ET, Sunday, September 14, 2025

Venue:  Caesars Superdome, New Orleans, LA

Where to Watch:  FOX

DraftKings:  Point Spread:  49ers -4.5, Saints +4.5; Over/Under:  41.5 points

Bet365:  Point Spread:  49ers -4.5, Saints +4.5; Over/Under:  42.5 points

BetMGM:  Point Spread:  49ers -4.5, Saints +4.5; Over/Under:  42.5 points

San Francisco 49ers:  1-0 (1st place, NFC West)

New Orleans Saints:  0-1 (3rd place, NFC South)

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San Francisco 49ers:  won their last game on the road against the Seattle Seahawks 17-13.

New Orleans Saints:  won their last game on the road against the New Orleans Saints 20-13.

The 49ers are entering this game with a 1-0 record overall and they have a 1-0 record in their divisional games too. They are 0-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Seattle Seahawks 17-13. Brock Purdy was the starting QB and he completed 26/35 passes for 277 passing yards, 2 touchdowns, and 2 interceptions. Christian McCaffrey led the team in rushing yards with 69. Ricky Pearsall led the receivers with 108 receiving yards on 4 receptions. Nick Bosa led the defense in that game with 6 solo tackles and 0 assisted tackles while Nick Bosa led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Saints are entering this game with a 0-1 record overall and they have a 0-0 record in their divisional games too. They are 0-1 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Arizona Cardinals 20-13. Spencer Rattler was the starting QB and he completed 27/46 passes for 214 passing yards, 0 touchdowns, and 0 interceptions. Alvin Kamara led the team in rushing yards with 45 and 1 TD. Juwan Johnson led the receivers with 76 receiving yards on 8 receptions. Pete Werner led the defense in that game with 7 solo tackles and 2 assisted tackles while Carl Granderson and Cameron Jordan each led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.

The current betting odds have the 49ers listed as a 4.5 point favorite in this game according to Draftkings Sportsbook. The 49ers have a 1-0 record this season and they gutted out a tough win in week 1. They had a disaster of a season last year and are looking to get back to the top this year, and that season opener was a good start. It wasn't a pretty win, but it was a really good one starting their season on the road in a divisional game after the year they had and they gutted out a 17-13 win against a Seahawks team that won 10 games a season ago. The defense looked great, making a big play at the end of the game to get them that win, and the offense still has a lot of talent even though they didn't look great. Meanwhile, the Saints have a 0-1 record this season after losing their season opener at home. They lost 20-13 to the Cardinals and didn't look terrible as they were right in that game, but they are still poised to be one of the worst teams in the NFL this season. They also played a Cardinals team that has been really up and down over the last few years and now they have to take on the team that has been running that division for the last few years. The defense didn't look bad, but the offense wasn't great and Rattler didn't show much last season when he got his opportunities. Kellen Moore still has a lot of work to do with this Saints team and they aren't going to be able to keep the game as close against a better team this week. The best way to place a bet here is on the 49ers to cover the spread in this game. 

49ers Saints Prediction:  Our NFL Pick for Sunday, September 14, 2025 (1:00 pm ET start time) is 49ers 30 Saints 13.

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San Francisco 49ers: 77-47 1H ATS as a road favorite. 54-33 1H ATS as a road favorite of 7 points or less. 11-5 OVER as a favorite of 3.5 to 9.5 points. 8-3 OVER after playing a division game. 6-3 OVER after allowing 14 points or less last game.

New Orleans Saints: 13-21 ATS in all games. 2-6 ATS as a home underdog of 7 points or less. 6-11 ATS in all games where the total is between 35.5 and 42 points. 29-20 OVER against NFC West division opponents. 39-28 OVER as a home underdog of 7 points or less.

San Francisco 49ers:  None.

New Orleans Saints:  None.

“I’m just so happy with our team. There was a lot of adversity in that game that we had to overcome: offense, defense, special teams. The number of turnovers. ... I was real proud of our team.” - Kyle Shanahan after his team’s win against the Seahawks in their last game. 

“Spence did some good stuff. I love the way he approached it, the mindset he played with. He gave us a chance.” - Kellen Moore after his team’s loss against the Cardinals in their last game. 

WR Jennings, Jauan

WR Pearsall, Ricky

WR Bourne, Kendrick

TE Kittle, George

QB Purdy, Brock

RB McCaffrey, Christian

FB Juszczyk, Kyle

WR Olave, Chris

WR Cooks, Brandin

WR Shaheed, Rashid

TE Johnson, Juwan

QB Rattler, Spencer

RB Kamara, Alvin

Passing: B. Purdy (277)

Rushing: C. McCaffrey (69)

Receiving: R. Pearsall (108)

Touchdowns: G. Kittle (1)

Passing: S. Rattler (214)

Rushing: A. Kamara (45)

Receiving: J. Johnson (76)

Touchdowns: A. Kamara (1)

Coaches:

San Francisco 49ers: Kyle Shanahan (9th season)

New Orleans Saints: Kellen Moore (1st season)