by Rod Pearson
Tuesday, Sep 30, 2025
Game Time: 8:15 pm ET, Thursday, October 2, 2025
Venue: SoFi Stadium, Inglewood, CA
Where to Watch: Prime Video
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: 49ers +5.5, Rams -5.5; Over/Under: 47.5 points
Bet365: Point Spread: 49ers +5.5, Rams -5.5; Over/Under: 47 points
BetMGM: Point Spread: 49ers +5.5, Rams -5.5; Over/Under: 47 points
Season Record
San Francisco 49ers: 3-1 (1st place, NFC West)
Los Angeles Rams: 3-1 (3rd place, NFC West)
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Recent Form
San Francisco 49ers: lost their last game at home against the Jacksonville Jaguars 26-21.
Los Angeles Rams: won their last game at home against the Indianapolis Colts 27-20.
San Francisco 49ers vs Los Angeles Rams Preview and Analysis
The 49ers are entering this game with a 3-1 record overall and they have a 2-0 record in their divisional games too. They are 1-1 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Jacksonville Jaguars 26-21. Brock Purdy was the starting QB and he completed 22/38 passes for 309 passing yards, 2 touchdowns, and 2 interceptions. Christian McCaffrey led the team in rushing yards with 49. Christian McCaffrey led the receivers with 92 receiving yards on 6 receptions and 1 TD. Dee Winters led the defense in that game with 9 solo tackles and 1 assisted tackle while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.
The Rams are entering this game with a 3-1 record overall and they have a 0-0 record in their divisional games too. They are 2-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Indianapolis Colts 27-20. Matthew Stafford was the starting QB and he completed 29/41 passes for 375 passing yards, 3 touchdowns, and 0 interceptions. Kyren Williams led the team in rushing yards with 77. Puka Nacua led the receivers with 170 receiving yards on 13 receptions and 1 TD. Quentin Lake led the defense in that game with 5 solo tackles and 4 assisted tackles while Jared Verse and Byron Young each led the defense in sacks with 1. Kamren Curl came away with the only 2 interceptions for them in that one.
49ers vs Rams Prediction
The current betting odds have the Rams listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. The Rams have looked really good in their games this season with their 3-1 record overall which has them right in the NFC West race early on. They are off a big bounce back win over the Colts last week and they could easily be 4-0 if it wasn't for a blocked field goal in the dying seconds of their loss against the Eagles. Their offense is starting to look a lot better now too and they can take advantage of this 49ers defense that is missing some key players. Meanwhile, the 49ers have also looked really good in their games this season with their 3-1 record overall which has them right in the division race too. The 49ers are also 2-0 in the division so they have an early jump there, but the Rams are only going to be motivated more to pick up a division win. The 49ers are dealing with a lot of injuries again and their offense hasn't looked that great in their games this season. Brock Purdy came back last week after missing 2 games, but he hasn't looked great in either of his starts and this is a tough game for the 49ers to go on the road on a short week when they haven't looked great lately. This is a great opportunity for the Rams to get a statement win at home in this division. The best way to place a bet here is on the Rams to cover the spread in this game.
49ers Rams Prediction: Our NFL Pick for Thursday, October 2, 2025 (8:15 pm ET start time) is Rams 24 49ers 17.
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NFL Betting Trends
San Francisco 49ers: 16-24 ATS in all games. 0-4 ATS as an underdog of 3.5 to 9.5 points. 1-11 ATS vs. good passing teams averaging 7 or more passing yards/att. 8-4 OVER off an upset loss as a favorite. 8-4 OVER vs. good offensive teams - scoring 24 or more points/game.
Los Angeles Rams: 24-15 ATS in all games. 13-6 ATS as a favorite. 7-2 ATS when playing against a top-level team (Win Pct. > 75%). 8-3 OVER off a home win. 6-3 OVER when playing against a top-level team (Win Pct. > 75%).
Key Injuries
San Francisco 49ers: R. Beal Jr. (DL) Injured - Ankle. C. McKivitz (OG) Injured - Calf. D. Winters (LB) Injured - Knee. M. Williams (DL) Injured - Wrist. R. Pearsall (WR) Injured - Knee. B. Purdy (QB) Injured - Toe. J. Watkins (WR) Injured - Calf. M. Jones (QB) Injured - Knee. C. West (DL) Injured - Thumb. R. Green (CB) Injured - Neck. Y. Gross-Matos (DL) Injured - Knee. J. Jennings (WR) Injured - Ankle.
Los Angeles Rams: T. Higbee (TE) Injured - Hip. R. Havenstein (OG) Injured - Ankle. C. Parkinson (TE) Injured - Shoulder. S. Avila (OG) Injured - Ankle. K. Kinchens (S) Injured - Shoulder.
Notable Quotes
“As an offense we have to play better than today and our team knows it. Offense needs to protect the ball and defense needs to go take it. That’s our game. So today on offense, we didn’t succeed in any of it. It hurts.” - Brock Purdy after their loss against the Jags in their last game.
“I was so proud of him, so happy for him. Like Sean said, he’s done everything we’ve asked him to do. That’s the guy he is. He comes to work every day to do whatever is asked of him, and he made the biggest play in the biggest moment.” - Matt Stafford on Atwell after their win against the Colts in their last game.
Starting Lineups
San Francisco 49ers
WR Robinson, Demarcus
WR Bourne, Kendrick
WR Jennings, Jauan
TE Tonges, Jake
QB Purdy, Brock
RB McCaffrey, Christian
FB Juszczyk, Kyle
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Whittington, Jordan
TE Higbee, Tyler
QB Stafford, Matthew
RB Williams, Kyren
Statistical Leaders
San Francisco 49ers
Passing: Brock Purdy (586)
Rushing: Christian McCaffrey (225)
Receiving: Ricky Pearsall (327)
Touchdowns: Christian McCaffrey (2)
Los Angeles Rams
Passing: Matthew Stafford (1,114)
Rushing: Kyren Williams (303)
Receiving: Puka Nacua (503)
Touchdowns: Davante Adams (3)
Coaches:
San Francisco 49ers: Kyle Shanahan (9th season)
Los Angeles Rams: Sean McVay (9th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
