San Francisco 49ers vs Los Angeles Rams Prediction, Preview and Odds - 09/10/2026

Game Time: 8:35 pm ET, Thursday, September 10, 2026

Venue:  Melbourne Cricket Ground, Melbourne, Australia

Where to Watch:  Netflix

DraftKings:  Point Spread:  49ers +3.5, Rams -3.5; Over/Under:  48.5 points

Bet365:  Point Spread:  49ers +3.5, Rams -3.5; Over/Under:  48.5 points

BetMGM:  Point Spread:  49ers +3.5, Rams -3.5; Over/Under:  48.5 points

San Francisco 49ers:  0-0 (NFC West)

Los Angeles Rams:  0-0 (NFC West)

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San Francisco 49ers:  N/A

Los Angeles Rams:  N/A

The 49ers finished last season with a 12-5 record overall and they were 4-2 in their division games too. They had a 5-3 record in their home games and had a 7-2 record in their road games, but they will be at a neutral site in Australia for this game. Last season, their offense was averaging 25.7 points per game and their defense was allowing an average of 21.8 points per game. Their offense was also averaging 351.4 yards per game and their defense was allowing an average of 340.2 yards per game. Brock Purdy led the team in passing yards with 2,167, Christian McCaffrey led the team in rushing yards with 1,202, and Christian McCaffrey led the team in receiving yards with 924.

The Rams finished last season with a 12-5 record overall and they were 4-2 in their division games too. They had a 7-1 record in their home games and had a 5-4 record in their road games, but they will be at a neutral site in Australia for this game. Last season, their offense was averaging 30.5 points per game and their defense was allowing an average of 20.4 points per game. Their offense was also averaging 394.6 yards per game and their defense was allowing an average of 327.5 yards per game. Matthew Stafford led the team in passing yards with 4,707, Kyren Williams led the team in rushing yards with 1,252, and Puka Nacua led the team in receiving yards with 1,715.

The current betting odds have the Rams listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The Rams had a great season going 12-5 and they were one of the best teams in the NFL. They ended up losing to the Seahawks 31-27 in the NFC Championship, the Seahawks going on to win the whole thing, but that could have easily been the Rams if things broke their way in that game. Now they are entering a new season with high hopes and they made some big moves to improve in the off-season. They traded for Myles Garrett and also got Aaron Donald out of retirement, so they are entering this season with one of the best defenses in the NFL. They also improved their secondary which was a big issue last season and even though they have the Super Bowl champions in their division, the Rams actually enter the season as the Super Bowl favorites for this year. Meanwhile, the 49ers also had a great season going 12-5, but they really started to fizzle out by the end of the season. Their offense wasn't putting up many points near the end and they did get embarrassed by the Seahawks in the playoffs, losing 41-6. They haven't done much to improve this offense either, bringing back some familiar but aging faces, and injuries have really been the story of this team the last few years. This game is also going to be in Australia, so neither team is going to be in their comfort zone here and the 49ers have been dealing with a ton of distractions off the field too. Signs are showing for the 49ers to take a step back this season while the Rams should be one of the best in the league and will be more prepared for this season opener. The best way to place a bet here is on the Rams to cover the spread in this game. 

49ers Rams Prediction:  Our NFL Pick for Thursday, September 10, 2026 (8:35 pm ET start time) is Rams 24 49ers 10.

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San Francisco 49ers: 3-9 ATS as an underdog. 2-7 ATS as an underdog of 3.5 to 9.5 points. 4-9 ATS versus division opponents. 7-2 OVER as an underdog of 3.5 to 9.5 points. 

Los Angeles Rams: 22-16 ATS in all games. 15-9 ATS as a favorite. 18-11 OVER against conference opponents. 9-4 OVER versus division opponents.

San Francisco 49ers:  None.

Los Angeles Rams:  None.

"We're going to get them out there in these three days and hope it goes well." - Kyle Shanahan on his team’s season opener against the LA Rams in Australia. 

“Here’s what I would tell you though. I know we've laughed and had some good fun interactions about it, but I do want to be able – I think they have a loose idea of what we're doing but I do still think it is appropriate in terms of the trajectory. I want to be able to talk to them about it, but we're leaving later than most people would probably expect.” - Sean McVay on his team’s late travel plans to Australia for their season opener against the 49ers.

WR Evans, Mike

WR Samuel Sr, Deebo

WR Stribling, De'Zhaun

TE Kittle, George

QB Purdy, Brock

RB McCaffrey, Christian

FB Juszczyk, Kyle

WR Adams, Davante

WR Nacua, Puka

WR Whittington, Jordan

TE Parkinson, Colby

QB Stafford, Matthew

RB Williams, Kyren

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

San Francisco 49ers: Kyle Shanahan (10th season)

Los Angeles Rams: Sean McVay (10th season)