by Rod Pearson
Tuesday, Oct 21, 2025
Game Time: 1:00 pm ET, Sunday, October 26, 2025
Venue: NRG Stadium, Houston, TX
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: 49ers +1.5, Texans -1.5; Over/Under: 41.5 points
Bet365: Point Spread: 49ers +1, Texans -1; Over/Under: 41.5 points
BetMGM: Point Spread: 49ers +1, Texans -1; Over/Under: 41.5 points
Season Record
San Francisco 49ers: 5-2 (1st place, NFC West)
Houston Texans: 2-4 (3rd place, AFC South)
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San Francisco 49ers: won their last game at home against the Atlanta Falcons 20-10.
Houston Texans: lost their last game on the road against the Seattle Seahawks 27-19.
San Francisco 49ers vs Houston Texans Preview and Analysis
The 49ers are entering this game with a 5-2 record overall and they have a 3-0 record in their divisional games too. They are 2-1 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Atlanta Falcons 20-10. Mac Jones was the starting QB and he completed 17/26 passes for 152 passing yards, 0 touchdowns, and 1 interception. Christian McCaffrey led the team in rushing yards with 129 and 2 TDs. Christian McCaffrey led the receivers with 72 receiving yards on 7 receptions. Ji'Ayir Brown led the defense in that game with 5 solo tackles and 0 assisted tackles while Bryce Huff and Sam Okuayinonu each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Texans are entering this game with a 2-4 record overall and they have a 1-1 record in their divisional games too. They are 1-1 in their home games, 1-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Seattle Seahawks 27-19. C. J. Stroud was the starting QB and he completed 23/49 passes for 229 passing yards, 1 touchdown, and 1 interception. C. J. Stroud led the team in rushing yards with 25. Dalton Schultz led the receivers with 98 receiving yards on 9 receptions. Kamari Lassiter led the defense in that game with 7 solo tackles and 3 assisted tackles while Will Anderson Jr. and Denico Autry each led the defense in sacks with 1. Calen Bullock and Derek Stingley Jr. each came away with 1 interception for them in that one.
49ers vs Texans Prediction
The current betting odds have the 49ers listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The 49ers have looked great in their games this season with their 5-2 record overall which has them right at the top of the NFC West. They have an advantage in the NFC West with their 3-0 division record this season, but it is still a really competitive division so they can't afford to slow down at all. They are off a 20-10 win over the Falcons in their last one and even with their injuries piling up, they continue to find ways to get the job done each week. Meanwhile, the Texans haven't looked good in their games this season with their 2-4 record overall which has them right near the bottom of the AFC South. They got off to a slow start this season which would normally be fine in this division, but the Colts and the Jaguars both having good starts to the season has put the Texans in a bad situation as the pressure starts to build. They aren't in a good situation here either, coming off a 27-19 loss to the Seahawks on Monday night so they are coming back from the West coast on a shorter week. The Texans do have a really good defense that is one of the best in the NFL this year as they don't give up many points, but the offense has been a big issue for them. Their offense hasn't looked good at all this season and they don't really have a solid RB to lean on either. This is a bad situation for the Texans coming back home against a more stable team. The best way to place a bet here is on the 49ers to cover the spread in this game.
49ers Texans Prediction: Our NFL Pick for Sunday, October 26, 2025 (1:00 pm ET start time) is 49ers 21 Texans 13.
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NFL Betting Trends
San Francisco 49ers: 4-8 ATS in non-conference games. 1-5 ATS vs. good teams - outscoring opponents by 6+ PPG on the season. 1-5 ATS vs. good defensive teams who give up 17 or less points/game. 25-18 OVER in all games. 7-3 OVER after allowing 14 points or less last game.
Houston Texans: 10-5 ATS in all games where the total is between 35.5 and 42 points. 7-4 ATS when playing against a good team (Win Pct. 60% to 75%). 10-5 OVER in all games where the total is between 35.5 and 42 points.
Key Injuries
San Francisco 49ers: T. Williams (OT) Injured - NIR-Rest. J. Brendel (OG) Injured - Hamstring. C. McCaffrey (RB) Injured - NIR-Rest. M. Jones (QB) Injured - Knee. K. Davis (DL) Injured - Hand. B. Huff (DL) Injured - Hamstring. L. Gifford (LB) Injured - Hamstring. D. Lenoir (CB) Injured - Quadricep. Y. Gross-Matos (DL) Injured - Knee. J. Jennings (WR) Injured - Ankle. B. Purdy (QB) Injured - Toe. S. Burford (OG) Injured - Knee. R. Green (CB) Injured - Toe. R. Pearsall (WR) Injured - Knee. U. Stout (CB) Injured - Ankle. C. West (DL) Injured - Thumb.
Houston Texans: D. Taylor (DL) Injured - Illness. D. Autry (DL) Injured - Knee. D. Barnett (DL) Injured - Ankle. C. Kirk (WR) Injured - Hamstring. D. Schultz (TE) Injured - Back. N. Collins (WR) Injured - Concussion. B. Bates (TE) Injured - Wrist. A. Huzzie (CB) Injured - Knee. J. Smith (CB) Injured - Hamstring.
Notable Quotes
“He’s the most consistent player I’ve been around. He just allows you to stay on track. He gets every yard in the run game and more. What he does in the pass game, it’s rare that you throw the ball to him and not get a completion." - Kyle Shanahan after his team’s win against the Falcons in their last game.
“Our defense kept us in the whole game. Got to help those guys out and score some points somehow, some way.” - C.J. Stroud after their loss against the Seahawks in their last game.
Starting Lineups
San Francisco 49ers
WR Bourne, Kendrick
WR Robinson, Demarcus
WR Jennings, Jauan
TE Kittle, George
QB Jones, Mac
RB McCaffrey, Christian
FB Juszczyk, Kyle
Houston Texans
WR Collins, Nico
WR Hutchinson, Xavier
WR Higgins, Jayden
TE Schultz, Dalton
QB Stroud, C.J.
RB Chubb, Nick
FB Brooks, British
Statistical Leaders
San Francisco 49ers
Passing: Mac Jones (1,404)
Rushing: Christian McCaffrey (465)
Receiving: Christian McCaffrey (516)
Touchdowns: Christian McCaffrey (6)
Houston Texans
Passing: C.J. Stroud (1,305)
Rushing: Nick Chubb (265)
Receiving: Nico Collins (339)
Touchdowns: Nico Collins (3)
Coaches:
San Francisco 49ers: Kyle Shanahan (9th season)
Houston Texans: DeMeco Ryans (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
