by Rod Pearson
Friday, Nov 13, 2026
Game Time: 4:25 pm ET, Sunday, November 15, 2026
Venue: AT&T Stadium, Arlington, TX
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: 49ers -3.5, Cowboys +3.5; Over/Under: 55.5 points
Bet365: Point Spread: 49ers -4, Cowboys +4; Over/Under: 55.5 points
BetMGM: Point Spread: 49ers -4, Cowboys +4; Over/Under: 55.5 points
Season Record
San Francisco 49ers: 7-1 (1st place, NFC West)
Dallas Cowboys: 4-5 (2nd place, NFC East)
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Recent Form
San Francisco 49ers: won their last game at home against the Las Vegas Raiders 38-17.
Dallas Cowboys: won their last game on the road against the Indianapolis Colts 27-23.
San Francisco 49ers vs Dallas Cowboys Preview and Analysis
The 49ers are entering this game with a 7-1 record overall and they have a 3-0 record in their divisional games too. They are 5-0 in their home games, 1-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Las Vegas Raiders 38-17. Brock Purdy was the starting QB and he completed 17/25 passes for 232 passing yards, 2 touchdowns, and 1 interception. Kaelon Black led the team in rushing yards with 70. Jordan Watkins led the receivers with 86 receiving yards on 4 receptions and 1 TD. Dre Greenlaw led the defense in that game with 8 solo tackles while no one on the defense recorded a sack for them. Jaden Dugger, Renardo Green, and Malik Mustapha each came away with 1 interception for them in that one.
The Cowboys are entering this game with a 4-5 record overall and they have a 2-1 record in their divisional games too. They are 1-2 in their home games, 3-2 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They won their last game against the Indianapolis Colts 27-23. Dak Prescott was the starting QB and he completed 21/34 passes for 335 passing yards, 2 touchdowns, and 0 interceptions. Javonte Williams led the team in rushing yards with 101 and 1 TD. CeeDee Lamb led the receivers with 195 receiving yards on 10 receptions and 1 TD. Quinnen Williams led the defense in that game with 7 solo tackles while Rashan Gary and Caleb Downs each led the defense in sacks with 1. Caleb Downs came away with the only interception for them in that one.
49ers vs Cowboys Prediction
The current betting odds have the 49ers listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The 49ers have looked great in their games this season with their 7-1 record overall which has them right at the top of the NFC West. They haven't been a great road team though with their 1-1 road record this year. Meanwhile, the Cowboys haven't looked great in their games this season with their 4-5 record overall, but that record has them right near the top of the NFC East. They haven't looked great on their home field though with their 1-2 home record this season. The Cowboys are coming off a 27-23 win over the Colts in their last one and they beat up on a team that turned into a fire sale at the trade deadline, but they still had trouble winning that game. They needed a late go-ahead drive to win and even with one of the best offenses in the NFL, they have a terrible defense that has been holding them back. The 49ers are coming off a 38-17 win over the Raiders in their last one and they have been rolling all season. They had 1 slip up against the Falcons, but Brock Purdy has been playing like the MVP this season. They have one of the best offenses in the NFL that continues to put up points no matter who is getting the ball and they are going to put up a ton of points with how bad this Cowboys defense has been. The 49ers also have the talent on defense to stop this banged up Cowboys offense though and that is going to be a big factor here. The best way to place a bet here is on the 49ers to cover the spread in this game.
49ers Cowboys Prediction: Our NFL Pick for Sunday, November 15, 2026 (4:25 pm ET start time) is 49ers 42 Cowboys 28.
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NFL Betting Trends
San Francisco 49ers: 9-5 ATS versus poor rushing defenses - allowing 4.5 rushing yards/carry or more. 12-4 1H ATS as a favorite of 3.5 to 9.5 points. 7-1 1H ATS in all games where the total is greater than or equal to 49.5. 11-4 OVER vs. good offensive teams - scoring 24 or more points/game. 11-5 OVER versus good offensive teams - averaging 350 yards/game or more.
Dallas Cowboys: 3-12 ATS in all games where the total is greater than or equal to 49.5. 4-8 ATS vs. good passing teams averaging 7 or more passing yards/att. 5-10 ATS versus good rushing teams - averaging 4.5 rushing yards/carry or more. 17-8 OVER as an underdog. 11-4 OVER in a home game where the total is greater than or equal to 45.5.
Key Injuries
San Francisco 49ers: T. Williams (OT) Injured - Shoulder. C. McCaffrey (RB) Injured - Rest. D. Robinson (WR) Injured - Ankle. M. Evans (WR) Injured - Achilles. D. Greenlaw (LB) Injured - Knee. S. Neal (CB) Injured - Knee. N. Hobbs (CB) Injured - Adductor. D. Lenoir (CB) Injured - Foot. D. Samuel Sr. (WR) Injured - Hamstring. R. Green (CB) Injured - Back. U. Stout (CB) Injured - Shoulder. C. West (DL) Injured - Knee.
Dallas Cowboys: A. Clark (S) Injured - Illness. J. Bullard (DL) Injured - Calf. P. Locke (S) Injured - Concussion. J. Ferguson (TE) Injured - Knee. L. Schoonmaker (TE) Injured - Groin. D. Overshown (LB) Injured - Hamstring. J. Porter Jr. (CB) Injured - Ankle. J. Mingo (WR) Injured - Ankle. G. Pickens (WR) Injured - Hamstring. T. Goodson (RB) Injured - Ankle. M. Liufau (LB) Injured - Forearm. B. Spann-Ford (TE) Injured - Shoulder. D. Ezeiruaku (LB) Injured - Ankle. D. Moore (CB) Injured - Hip.
Notable Quotes
“He’s made a huge step forward. He hasn’t had his opportunities, but guys have been down and he’s been working and he’s been ready for it. He’s been better each week.” - Kyle Shanahan after his team’s win against the Raiders in their last game.
“It's good to clean things up with a win. The way to get consistent is to get back to work and make sure we're doing everything right, discipline and details and make sure we're playing better.” - Dak Prescott after their win against the Colts in their last game.
Starting Lineups
San Francisco 49ers
WR Robinson, Demarcus
WR Watkins, Jordan
WR Allen, Keenan
TE Kittle, George
QB Purdy, Brock
RB McCaffrey, Christian
FB Juszczyk, Kyle
Dallas Cowboys
WR Brown, Camden
WR Lamb, CeeDee
WR Flournoy, Ryan
TE Spann-Ford, Brevyn
QB Prescott, Dak
RB Williams, Javonte
FB Luepke, Hunter
Statistical Leaders
San Francisco 49ers
Passing: Brock Purdy (1,980)
Rushing: Christian McCaffrey (457)
Receiving: George Kittle (483)
Touchdowns: Christian McCaffrey (10)
Dallas Cowboys
Passing: Dak Prescott (2,381)
Rushing: Javonte Williams (629)
Receiving: CeeDee Lamb (904)
Touchdowns: Javonte Williams (10)
Coaches:
San Francisco 49ers: Kyle Shanahan (10th season)
Dallas Cowboys: Brian Schottenheimer (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
