San Francisco 49ers vs Atlanta Falcons Prediction, Preview and Odds - 10/25/2026

Game Time: 1:00 pm ET, Sunday, October 25, 2026

Venue:  Mercedes-Benz Stadium, Atlanta, GA

Where to Watch:  FOX

DraftKings:  Point Spread:  49ers -3, Falcons +3; Over/Under:  50.5 points

Bet365:  Point Spread:  49ers -3, Falcons +3; Over/Under:  50.5 points

BetMGM:  Point Spread:  49ers -3.5, Falcons +3.5; Over/Under:  50.5 points

San Francisco 49ers:  6-0 (1st place, NFC West)

Atlanta Falcons:  2-4 (2nd place, NFC South)

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San Francisco 49ers:  won their last game at home against the Washington Commanders 23-17.

Atlanta Falcons:  lost their last game at home against the Chicago Bears 31-23.

The 49ers are entering this game with a 6-0 record overall and they have a 3-0 record in their divisional games too. They are 4-0 in their home games, 1-0 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Washington Commanders 23-17. Brock Purdy was the starting QB and he completed 21/29 passes for 264 passing yards, 1 touchdown, and 0 interceptions. Christian McCaffrey led the team in rushing yards with 64 and 2 TDs. Mike Evans led the receivers with 94 receiving yards on 3 receptions. Jaden Dugger led the defense in that game with 11 solo tackles while Osa Odighizuwa, Mykel Williams, and Gracen Halton each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Falcons are entering this game with a 2-4 record overall and they have a 1-1 record in their divisional games too. They are 0-3 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Chicago Bears 31-23. Michael Penix Jr. was the starting QB and he completed 19/33 passes for 225 passing yards, 3 touchdowns, and 0 interceptions. Bijan Robinson led the team in rushing yards with 61. Jahan Dotson led the receivers with 87 receiving yards on 3 receptions and 1 TD. Sydney Brown, Mike Hughes, Jessie Bates III, and Kendal Daniels each led the defense in that game with 7 solo tackles while LaCale London, Gervon Dexter Sr., Brandon Dorlus, and Za'Darius Smith each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have the 49ers listed as a 3 point favorite in this game according to Draftkings Sportsbook. The 49ers have looked great in their games this season with their 6-0 record overall which has them right at the top of the NFC West. They have been a good road team too with their 1-0 road record this year. Meanwhile, the Falcons haven't looked great in their games this season with their 2-4 record overall which has them right in the middle of the NFC South. They have looked terrible on their home field too with their 0-3 home record this season. The Falcons are coming off a 31-23 loss to the Bears in their last one and that score is a lot closer than the game actually was. The Falcons fell behind right away and couldn't dig themselves out with a late comeback. Now they have lost 2 games in a row and they have been a really up and down team all year. They looked like the worst team in the NFL without a QB in their first 2 games and then looked like the best team in the NFL with Penix playing in the next 2 games, but now they have come back down to Earth to the average team that they are. The 49ers have been rolling though, being one of the few undefeated teams left in the NFL, and they have been picking up some good wins against top opponents too. The defense has looked great in most of their games this season and the offense has been rolling too with Purdy looking like the MVP at times. The Falcons have the potential to be a good team with the talent that they have, but they are too inconsistent and the 49ers can do everything that the Falcons can do but better. The best way to place a bet here is on the 49ers to cover the spread in this game. 

49ers Falcons Prediction:  Our NFL Pick for Sunday, October 25, 2026 (1:00 pm ET start time) is 49ers 30 Falcons 20.

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San Francisco 49ers: 4-8 ATS off a home win. 2-8 ATS after a win by 6 or less points. 3-6 ATS vs. bad defensive teams who give up 24 or more points/game. 13-6 OVER in road games. 9-4 OVER versus good rushing teams - averaging 4.5 rushing yards/carry or more. 

Atlanta Falcons: 7-3 ATS off a home loss. 5-1 ATS after a game with a turnover margin of -2 or worse. 7-4 ATS after allowing 30 points or more last game. 8-3 OVER as an underdog of 3.5 to 9.5 points. 9-3 OVER after allowing 30 points or more last game.

San Francisco 49ers:  None.

Atlanta Falcons:  None.

“You’re not always happy exactly with how some of the stuff was frustrating, but real proud of the guys for just the competitive stamina to keep it going all game. I was really proud of the defense for finding a way to overcome.” - Kyle Shanahan after his team’s win against the Commanders in their last game. 

“We talked at length about starting fast in this ball game, and we did not. That’s on me and our and our staff. We’ve got to get that fixed because that’s when we just put ourselves in the hole." - Kevin Stefanski after his team’s loss against the Bears in their last game. 

WR Evans, Mike

WR Cowing, Jacob

WR Watkins, Jordan

TE Kittle, George

QB Purdy, Brock

RB McCaffrey, Christian

FB Juszczyk, Kyle

WR London, Drake

WR Dotson, Jahan

WR Zaccheaus, Olamide

TE Pitts Sr., Kyle

QB Penix Jr., Michael

RB Robinson, Bijan

Passing: Brock Purdy (1,460)

Rushing: Christian McCaffrey (350)

Receiving: Mike Evans (420)

Touchdowns: Christian McCaffrey (7)

Passing: Michael Penix Jr. (944)

Rushing: Bijan Robinson (641)

Receiving: Drake London (550)

Touchdowns: Bijan Robinson (5)

Coaches:

San Francisco 49ers: Kyle Shanahan (10th season)

Atlanta Falcons: Kevin Stefanski (1st season)