San Diego Padres vs Seattle Mariners Prediction, Preview and Odds - 08/27/2025

Game Time: 4:10 pm ET, Wednesday, August 27, 2025

Venue:  T-Mobile Park, Seattle, WA

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Padres +108, Mariners -132; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Padres +110, Mariners -130; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Padres +110, Mariners -130; Over/Under:  7.5 runs

San Diego Padres:  74-58 (2nd place, NL West)

Seattle Mariners:  71-61 (2nd place, AL West)

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San Diego Padres:  5-5 last 10

Seattle Mariners:  4-6 last 10

The Padres are entering this series off a loss and won their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 74-58 record overall and have a road record of 31-36. This is the series finale of a 3-game series with the Mariners on Wednesday with the 2nd game still to be played on Tuesday. The Padres lost the series opener on Monday. Their offense ranks 19th in the MLB with a .706 OPS. Dylan Cease is their starting pitcher on Tuesday while Yu Darvish is making his start in this game on Wednesday. He is 3-3 with a 5.36 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 1 HR, and 1 BB with 5 SO on 1 hit through 6 IP against the Los Angeles Dodgers.

The Mariners are entering this series off a win and won their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 71-61 record overall and have a home record of 40-26. This is the 3rd game of a 3-game series with the Padres on Wednesday with the 2nd game of this series still to be played on Tuesday. The Mariners won the 1st game of this series on Monday. Their offense ranks 12th in the MLB with a .729 OPS. Luis Castillo is their starting pitcher on Tuesday while Bryan Woo is making his start in this game on Wednesday. He is 11-7 with a 2.94 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 2 walks with 7 strikeouts on 1 hit through 7 innings pitched against the Athletics.

The current betting odds have the Mariners listed as a slight favorite in this game according to Draftkings Sportsbook. The Mariners have looked good in their games this season with their 71-61 record overall which has them right near the top of the AL West. They have looked great in their own ballpark too with their 40-26 home record this year. Meanwhile, the Padres have looked really good in their games this season with their 74-58 record overall which has them right near the top of the NL West and in the division race. They haven't been a good road team though with their 31-36 road record this year. The Mariners haven't looked great lately, going 4-6 in their last 10 games, but they took the 1st game of this series and they do have the better pitching matchup to take advantage of here. The Mariners are going with Woo in this one and he has looked great this season. He is 11-7 with a 2.94 ERA and hasn't been giving up many runs all year. He is coming off another good start in which he only gave up 1 earned run and the team has had a lot of success with him lately too, winning 3 of their last 4 games with him starting. The Padres are going with Darvish in this one and he hasn't looked good this season. He is 3-3 with a 5.36 ERA and has been giving up quite a few runs in his starts. The team has won 4 of their last 5 games with him starting and he only gave up 1 earned run in his last start, but that hasn't been a common theme for him this year as he has been really up and down since coming back from his injury. The Mariners also have the better offense to win this game at home and they have been rolling lately too. The best way to place a bet here is on the Mariners to win this game. 

Padres Mariners Prediction:  Our MLB Pick for Wednesday, August 27, 2025 (4:10 pm ET start time) is Mariners 5 Padres 3.

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San Diego Padres: 254-210 (+4.3 units) on the moneyline in all games. 74-78 (+16.2 units) on the moneyline as an underdog of +100 or higher. 151-134 (+6.2 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 27-19 UNDER against AL West opponents.

Seattle Mariners: 244-212 (-11.5 units) on the moneyline in all games. 175-127 (-10.2 units) on the moneyline as a favorite of -110 or higher. 64-62 (-9.6 units) on the moneyline in an inter-league game. 23-15 UNDER against NL West opponents.

San Diego Padres:  J. Merrill (CF) Ten Day IL - Ankle. M. King (SP) Fifteen Day IL - Knee. J. Brito (RP) Sixty Day IL - Forearm. J. Musgrove (SP) Sixty Day IL - Elbow.

Seattle Mariners:  T. Thornton (RP) Sixty Day IL - Achilles. L. Evans (SP) Fifteen Day IL - Elbow. G. Santos (RP) Sixty Day IL - Knee. R. Bliss (2B) Sixty Day IL - Biceps.

“That would be huge. But, again, I love his at-bats. I love what he’s doing. His swing decisions have been elite almost all year.” - Mike Shildt on Tatis Jr after his team’s loss against the Mariners in their game on Monday. 

“I think everybody can tell you in there they're probably a little tired. I mean, that's just how it is. It's part of the season. Bodies weren't meant to go through a full 162 like this. But I feel good. I feel strong. I've been keeping my routine pretty much the same all year, and that's been a big component to staying healthy.” - Cal Raleigh after their win against the Padres in their game on Monday.

Fernando Tatis Jr. (R) RF

Luis Arraez (L) 1B

Manny Machado (R) 3B

Ryan O'Hearn (L) DH

Xander Bogaerts (R) SS

Gavin Sheets (L) LF

Ramón Laureano (R) CF

Jake Cronenworth (L) 2B

Freddy Fermin (R) C

Randy Arozarena (R) LF

Cal Raleigh (S) DH

Julio Rodríguez (R) CF

Eugenio Suárez (R) 3B

Josh Naylor (L) 1B

Mitch Garver (R) C

Jorge Polanco (S) 2B

J.P. Crawford (L) SS

Victor Robles (R) RF

Batting Average:  Will Wagner (.500)

Hits:  Manny Machado (147)

Home Runs:  Manny Machado (21)

RBI:  Manny Machado (78)

Stolen Bases:  Fernando Tatis (26)

Wins:  Nick Pivetta (13)

Saves:  Robert Suarez (34)

ERA:  Bradgley Rodriguez (0.00)

Batting Average:  Dominic Canzone (.289)

Hits:  Julio Rodríguez (140)

Home Runs:  Cal Raleigh (50)

RBI:  Cal Raleigh (107)

Stolen Bases:  Randy Arozarena (24)

Wins:  Bryan Woo (11)

Saves:  Andrés Muñoz (30)

ERA:  Jhonathan Díaz (0.00)

Managers:

San Diego Padres: Mike Shildt (2nd season)

Seattle Mariners: Dan Wilson (2nd season)