San Diego Padres vs San Francisco Giants Prediction, Preview and Odds - 08/12/2025

Game Time: 9:45 pm ET, Tuesday, August 12, 2025

Venue:  Oracle Park, San Francisco, CA

Where to Watch:  PADRES.tv, NBCS-BA

DraftKings:  Moneyline odds:  Padres +108, Giants -132; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Padres +110, Giants -130; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Padres +110, Giants -130; Over/Under:  7.5 runs

San Diego Padres:  66-52 (2nd place, NL West)

San Francisco Giants:  59-59 (3rd place, NL West)

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San Diego Padres:  7-3 last 10

San Francisco Giants:  5-5 last 10

The Padres are entering this series off a win and won their 3-game series against the Boston Red Sox 2-1 in their last series. They enter this game with a 66-52 record overall and have a road record of 28-32. This is the 2nd game of a 3-game series with the Giants on Tuesday with the series opener still to be played on Monday. Their offense ranks 22nd in the MLB with a .701 OPS. Yu Darvish is their starting pitcher on Monday while Nestor Cortes is making his start in this game on Tuesday. He is 1-1 with a 7.11 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 1 HR, and 3 BB with 3 SO on 3 hits through 4.2 IP against the Arizona Diamondbacks.

The Giants are entering this series off a loss and lost their 3-game series against the Washington Nationals 2-1 in their last series. They enter this game with a 59-59 record overall and have a home record of 29-28. This is the 2nd game of a 3-game series with the Padres on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 25th in the MLB with a .687 OPS. Logan Webb is their starting pitcher on Monday while Robbie Ray is making his start in this game on Tuesday. He is 9-5 with a 2.85 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 2 walks with 8 strikeouts on 6 hits through 6 innings pitched against the Pittsburgh Pirates.

The current betting odds have the Giants listed as a favorite in this game according to Draftkings Sportsbook. The Giants haven't looked great in their games this season with their 59-59 record overall which has them right in the middle of the NL West. They have looked better in their own ballpark with their 29-28 home record this season. Meanwhile, the Padres have looked really good in their games this season with their 66-52 record overall which has them right near the top of the NL West. They haven't been a good road team though with their 28-32 road record this season. The Padres have been red hot lately as they are 7-3 in their last 10 games while the Giants are only 5-5 in their last 10, but the Giants do have the better pitching matchup here and they can take advantage of that at home. Ray is on the mound for the Giants in this one and he has looked great this season. He is 9-5 with a 2.85 ERA and hasn't been giving up many runs lately. He is coming off another good start in which he only gave up 2 earned runs and the team has won 2 games in a row now with him starting too. The Padres are going with Cortes in this one and he hasn't looked good this season. He is 1-1 with a 7.11 ERA and has been giving up quite a few runs this year. He is coming off a better start in which he only gave up 2 earned runs and his team has won 2 games in a row now with him starting too, but that hasn't been a common theme for him this year and the Padres haven't looked as good in their road games either. The Giants can take advantage of this pitching matchup at home. The best way to place a bet here is on the Giants to win this game. 

Padres Giants Prediction:  Our MLB Pick for Tuesday, August 12, 2025 (9:45 pm ET start time) is Giants 6 Padres 1.

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San Diego Padres: 70-74 (+15.7 units) on the moneyline as an underdog of +100 or higher. 76-56 (+9.4 units) on the moneyline against left-handed starters. 86-57 (+9.3 units) on the moneyline vs. an NL team with a slugging percentage of .400 or worse on the season. 34-17 UNDER vs. an NL starting pitcher whose ERA is 3.20 or better.

San Francisco Giants: 219-223 (-31.5 units) on the moneyline in all games. 116-102 (-17.7 units) on the moneyline in home games. 122-106 (-33.3 units) on the moneyline as a favorite of -110 or higher. 90-54 UNDER as a home favorite of -110 or higher.

San Diego Padres:  J. Brito (RP) Sixty Day IL - Forearm. J. Musgrove (SP) Sixty Day IL - Elbow.

San Francisco Giants:  J. Encarnacion (RF) Ten Day IL - Hamstring. L. Roupp (SP) Fifteen Day IL - Elbow. E. Miller (RP) Fifteen Day IL - Elbow. T. Murphy (C) Sixty Day IL - Back.

“He just continues to be more consistent. He's just throwing the ball where he wants to; he's controlling counts better. And one of the indicators was his ability to go into the seventh -- his ability to be efficient with his pitches, dominate early in counts and to get quicker outs. We know he's got strikeout stuff, clearly, but those early outs and those controlled counts are important for his efficiency and for us.” - Mike Shildt after his team’s win against the Red Sox in their game on Sunday. 

“Unfortunately, that probably is as disappointing a game as we’ve had all year. Coming in here, we felt like we had a lot of momentum. We still feel like we have a really good team. We had a chance to win again today and just couldn’t put anything together. I’m frustrated [about] that. I’m frustrated that our fans come out and support us every night and we gave them literally nothing today.” - Bob Melvin after his team’s loss against the Nationals in their game on Sunday.

Fernando Tatis Jr. (R) RF

Luis Arraez (L) DH

Manny Machado (R) 3B

Ryan O'Hearn (L) 1B

Xander Bogaerts (R) SS

Jackson Merrill (L) CF

Ramón Laureano (R) LF

Jake Cronenworth (L) 2B

Freddy Fermin (R) C

Heliot Ramos (R) LF

Rafael Devers (L) 1B

Willy Adames (R) SS

Wilmer Flores (R) DH

Matt Chapman (R) 3B

Casey Schmitt (R) 2B

Jung Hoo Lee (L) CF

Patrick Bailey (S) C

Drew Gilbert (L) RF

Batting Average:  Freddy Fermin (.391)

Hits:  Luis Arraez (135)

Home Runs:  Manny Machado (20)

RBI:  Manny Machado (72)

Stolen Bases:  Fernando Tatis (24)

Wins:  Nick Pivetta (11)

Saves:  Robert Suarez (32)

ERA:  Bradgley Rodriguez (0.00)

Batting Average:  Dominic Smith (.280)

Hits:  Heliot Ramos (123)

Home Runs:  Willy Adames (18)

RBI:  Willy Adames (61)

Stolen Bases:  Tyler Fitzgerald (9)

Wins:  Logan Webb (10)

Saves:  Camilo Doval (15)

ERA:  Matt Gage (0.00)

Managers:

San Diego Padres: Mike Shildt (2nd season)

San Francisco Giants: Bob Melvin (2nd season)